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Protein

Protein lap1

Gene

Lap1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May have a role in assembling adherens junctions.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-DME-442729 CREB phosphorylation through the activation of CaMKII
R-DME-6798695 Neutrophil degranulation
R-DME-8863795 Downregulation of ERBB2 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9V780

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein lap1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lap1Imported
ORF Names:CG10255
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0033984 Lap1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001883061 – 849Protein lap1Add BLAST849

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9V780

PRoteomics IDEntifications database

More...
PRIDEi
Q9V780

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0033984 Expressed in 29 organ(s), highest expression level in Malpighian tubule

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9V780 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9V780 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
62412, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q9V780, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0086538

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9V780

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati18 – 39LRR 1Add BLAST22
Repeati41 – 62LRR 2Add BLAST22
Repeati64 – 85LRR 3Add BLAST22
Repeati87 – 108LRR 4Add BLAST22
Repeati110 – 131LRR 5Sequence analysisAdd BLAST22
Repeati133 – 155LRR 6Add BLAST23
Repeati156 – 177LRR 7Add BLAST22
Repeati179 – 200LRR 8Add BLAST22
Repeati202 – 224LRR 9Add BLAST23
Repeati225 – 246LRR 10Add BLAST22
Repeati248 – 269LRR 11Add BLAST22
Repeati271 – 292LRR 12Add BLAST22
Repeati294 – 315LRR 13Add BLAST22
Repeati317 – 338LRR 14Add BLAST22
Repeati340 – 362LRR 15Add BLAST23
Repeati363 – 384LRR 16Sequence analysisAdd BLAST22
Repeati386 – 407LRR 17Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini770 – 849PDZPROSITE-ProRule annotationAdd BLAST80

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LAP (LRR and PDZ) protein family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KCZ0 Eukaryota
COG4886 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9V780

KEGG Orthology (KO)

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KOi
K01768

Identification of Orthologs from Complete Genome Data

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OMAi
RRICFAE

Database of Orthologous Groups

More...
OrthoDBi
992188at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9V780

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 2 hits
PF00595 PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 13 hits
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 13 hits
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9V780-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLLSKCFPC FKFKREEVID KLDYSNTPLT DFPEVWQHER TLEELYLSTT
60 70 80 90 100
RLQALPPQLF YCQGLRVLHV NSNNLESIPQ AIGSLRQLQH LDLNRNLIVN
110 120 130 140 150
VPEEIKSCKH LTHLDLSCNS LQRLPDAITS LISLQELLLN ETYLEFLPAN
160 170 180 190 200
FGRLVNLRIL ELRLNNLMTL PKSMVRLINL QRLDIGGNEF TELPEVVGEL
210 220 230 240 250
KSLRELWIDF NQIRRVSANI GKLRDLQHFE ANGNLLDTLP SELSNWRNVE
260 270 280 290 300
VLSICSNSLE AFPFSVGMLK SLVTFKCESN GLTELPDSIS YLEQLEELVL
310 320 330 340 350
SHNKLIRLPS TIGMLRSLRF LFADDNQLRQ LPDELCSCQQ LSVLSVANNQ
360 370 380 390 400
LSALPQNIGN LSKMKVLNVV NNYINALPVS MLNLVNLTSM WLSDNQSQPL
410 420 430 440 450
VPLQYLDAST KTQLTCFMLP QVTFKMNSIQ AQQQAQEQYE FVYANQQQPH
460 470 480 490 500
ASPSRRICFA EEATILSNAK AQPAPNYPSF VAAPPTPTPD QMAGSVRLMR
510 520 530 540 550
SPTPYPKELR QMSKYVRQAQ AATSSANASE VREARVVTNG QIHCDSNNAN
560 570 580 590 600
QDVVDQATTS AIYGIAPETT HIYGVYQQPQ QMAHPVPTQE YYGLPLVNYE
610 620 630 640 650
AHYQQLYVEA NTPLPTTHLN GDQDYELQPL QQQPMQQQAL PTPRLEPPPY
660 670 680 690 700
HIARVYTKKT PEDLNLYESM RQRKQQQQLQ EQTIYQDALN SNSNFKTTAI
710 720 730 740 750
GAQDVEESVD QLDYQNNISN NLEPNPEEED QELDDTMSQH SLNSTATNNT
760 770 780 790 800
SKASHKKSTW IFGVHKNPTV KQVTLKWENS IGFDIAELLN QVGIFVSSIT
810 820 830 840
PNTNAARLLN LNDKLLEIDG YDLTNANLSD AKRVLLNCGT VMNIMLSRK
Length:849
Mass (Da):96,148
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC86DD96C242080E2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4JCT8A0A0B4JCT8_DROME
Lap1, isoform B
Lap1 CT28815, dLAP1, dlap1, Dmel\CG10255, CG10255
849Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58179.1
BT011365 mRNA Translation: AAR96157.1

NCBI Reference Sequences

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RefSeqi
NP_001188938.1, NM_001202009.2
NP_611007.1, NM_137163.5

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Dm.12431

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087407; FBpp0086538; FBgn0033984
FBtr0303759; FBpp0292771; FBgn0033984

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36670

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG10255

UCSC genome browser

More...
UCSCi
CG10255-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58179.1
BT011365 mRNA Translation: AAR96157.1
RefSeqiNP_001188938.1, NM_001202009.2
NP_611007.1, NM_137163.5
UniGeneiDm.12431

3D structure databases

ProteinModelPortaliQ9V780
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi62412, 6 interactors
IntActiQ9V780, 2 interactors
STRINGi7227.FBpp0086538

Proteomic databases

PaxDbiQ9V780
PRIDEiQ9V780

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087407; FBpp0086538; FBgn0033984
FBtr0303759; FBpp0292771; FBgn0033984
GeneIDi36670
KEGGidme:Dmel_CG10255
UCSCiCG10255-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36670
FlyBaseiFBgn0033984 Lap1

Phylogenomic databases

eggNOGiENOG410KCZ0 Eukaryota
COG4886 LUCA
InParanoidiQ9V780
KOiK01768
OMAiRRICFAE
OrthoDBi992188at2759
PhylomeDBiQ9V780

Enzyme and pathway databases

ReactomeiR-DME-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-DME-442729 CREB phosphorylation through the activation of CaMKII
R-DME-6798695 Neutrophil degranulation
R-DME-8863795 Downregulation of ERBB2 signaling
SignaLinkiQ9V780

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36670

Protein Ontology

More...
PROi
PR:Q9V780

Gene expression databases

BgeeiFBgn0033984 Expressed in 29 organ(s), highest expression level in Malpighian tubule
ExpressionAtlasiQ9V780 baseline and differential
GenevisibleiQ9V780 DM

Family and domain databases

Gene3Di3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 13 hits
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 13 hits
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAP1_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9V780
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 1, 2000
Last modified: January 16, 2019
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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