Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9V780 (LAP1_DROME)

Entry version 143 (02 Dec 2020)
Sequence version 1 (01 May 2000)
Previous versions | rss
Add a publicationFeedback
Protein

Protein lap1

Gene

Lap1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May have a role in assembling adherens junctions.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9V780

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein lap1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lap1Imported
ORF Names:CG10255
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0033984, Lap1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001883061 – 849Protein lap1Add BLAST849

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9V780

PRoteomics IDEntifications database

More...PRIDEi		Q9V780

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0033984, Expressed in Malpighian tubule and 37 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9V780, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9V780, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		62412, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q9V780, 2 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0086538

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati18 – 39LRR 1Add BLAST22
Repeati41 – 62LRR 2Add BLAST22
Repeati64 – 85LRR 3Add BLAST22
Repeati87 – 108LRR 4Add BLAST22
Repeati110 – 131LRR 5Sequence analysisAdd BLAST22
Repeati133 – 155LRR 6Add BLAST23
Repeati156 – 177LRR 7Add BLAST22
Repeati179 – 200LRR 8Add BLAST22
Repeati202 – 224LRR 9Add BLAST23
Repeati225 – 246LRR 10Add BLAST22
Repeati248 – 269LRR 11Add BLAST22
Repeati271 – 292LRR 12Add BLAST22
Repeati294 – 315LRR 13Add BLAST22
Repeati317 – 338LRR 14Add BLAST22
Repeati340 – 362LRR 15Add BLAST23
Repeati363 – 384LRR 16Sequence analysisAdd BLAST22
Repeati386 – 407LRR 17Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini770 – 849PDZPROSITE-ProRule annotationAdd BLAST80

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LAP (LRR and PDZ) protein family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0619, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_336254_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9V780

Identification of Orthologs from Complete Genome Data

More...OMAi		RRICFAE

Database of Orthologous Groups

More...OrthoDBi		992188at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9V780

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 1 hit
3.80.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR001478, PDZ
IPR036034, PDZ_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13855, LRR_8, 3 hits
PF00595, PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00369, LRR_TYP, 13 hits
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51450, LRR, 13 hits
PS50106, PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9V780-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLLSKCFPC FKFKREEVID KLDYSNTPLT DFPEVWQHER TLEELYLSTT 
        60         70         80         90        100
RLQALPPQLF YCQGLRVLHV NSNNLESIPQ AIGSLRQLQH LDLNRNLIVN 
       110        120        130        140        150
VPEEIKSCKH LTHLDLSCNS LQRLPDAITS LISLQELLLN ETYLEFLPAN 
       160        170        180        190        200
FGRLVNLRIL ELRLNNLMTL PKSMVRLINL QRLDIGGNEF TELPEVVGEL 
       210        220        230        240        250
KSLRELWIDF NQIRRVSANI GKLRDLQHFE ANGNLLDTLP SELSNWRNVE 
       260        270        280        290        300
VLSICSNSLE AFPFSVGMLK SLVTFKCESN GLTELPDSIS YLEQLEELVL 
       310        320        330        340        350
SHNKLIRLPS TIGMLRSLRF LFADDNQLRQ LPDELCSCQQ LSVLSVANNQ 
       360        370        380        390        400
LSALPQNIGN LSKMKVLNVV NNYINALPVS MLNLVNLTSM WLSDNQSQPL 
       410        420        430        440        450
VPLQYLDAST KTQLTCFMLP QVTFKMNSIQ AQQQAQEQYE FVYANQQQPH 
       460        470        480        490        500
ASPSRRICFA EEATILSNAK AQPAPNYPSF VAAPPTPTPD QMAGSVRLMR 
       510        520        530        540        550
SPTPYPKELR QMSKYVRQAQ AATSSANASE VREARVVTNG QIHCDSNNAN 
       560        570        580        590        600
QDVVDQATTS AIYGIAPETT HIYGVYQQPQ QMAHPVPTQE YYGLPLVNYE 
       610        620        630        640        650
AHYQQLYVEA NTPLPTTHLN GDQDYELQPL QQQPMQQQAL PTPRLEPPPY 
       660        670        680        690        700
HIARVYTKKT PEDLNLYESM RQRKQQQQLQ EQTIYQDALN SNSNFKTTAI 
       710        720        730        740        750
GAQDVEESVD QLDYQNNISN NLEPNPEEED QELDDTMSQH SLNSTATNNT 
       760        770        780        790        800
SKASHKKSTW IFGVHKNPTV KQVTLKWENS IGFDIAELLN QVGIFVSSIT 
       810        820        830        840 
PNTNAARLLN LNDKLLEIDG YDLTNANLSD AKRVLLNCGT VMNIMLSRK
Length:849
Mass (Da):96,148
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC86DD96C242080E2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4JCT8A0A0B4JCT8_DROME
Lap1, isoform B
Lap1 CT28815, dLAP1, dlap1, Dmel\CG10255, CG10255
849Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58179.1
BT011365 mRNA Translation: AAR96157.1

NCBI Reference Sequences

More...RefSeqi		NP_001188938.1, NM_001202009.2
NP_611007.1, NM_137163.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0087407; FBpp0086538; FBgn0033984
FBtr0303759; FBpp0292771; FBgn0033984

Database of genes from NCBI RefSeq genomes

More...GeneIDi		36670

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG10255

UCSC genome browser

More...UCSCi		CG10255-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58179.1
BT011365 mRNA Translation: AAR96157.1
RefSeqiNP_001188938.1, NM_001202009.2
NP_611007.1, NM_137163.5

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi62412, 6 interactors
IntActiQ9V780, 2 interactors
STRINGi7227.FBpp0086538

Proteomic databases

PaxDbiQ9V780
PRIDEiQ9V780

Genome annotation databases

EnsemblMetazoaiFBtr0087407; FBpp0086538; FBgn0033984
FBtr0303759; FBpp0292771; FBgn0033984
GeneIDi36670
KEGGidme:Dmel_CG10255
UCSCiCG10255-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		36670
FlyBaseiFBgn0033984, Lap1

Phylogenomic databases

eggNOGiKOG0619, Eukaryota
HOGENOMiCLU_336254_0_0_1
InParanoidiQ9V780
OMAiRRICFAE
OrthoDBi992188at2759
PhylomeDBiQ9V780

Enzyme and pathway databases

SignaLinkiQ9V780

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		36670, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		36670

Protein Ontology

More...PROi		PR:Q9V780

Gene expression databases

BgeeiFBgn0033984, Expressed in Malpighian tubule and 37 other tissues
ExpressionAtlasiQ9V780, baseline and differential
GenevisibleiQ9V780, DM

Family and domain databases

Gene3Di2.30.42.10, 1 hit
3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR001478, PDZ
IPR036034, PDZ_sf
PfamiView protein in Pfam
PF13855, LRR_8, 3 hits
PF00595, PDZ, 1 hit
SMARTiView protein in SMART
SM00369, LRR_TYP, 13 hits
SM00228, PDZ, 1 hit
SUPFAMiSSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 13 hits
PS50106, PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAP1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9V780
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 1, 2000
Last modified: December 2, 2020
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again