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UniProtKB - Q9V776 (CP317_DROME)
Protein
Probable cytochrome P450 317a1
Gene
Cyp317a1
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
By similarityCofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 461 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- monooxygenase activity Source: UniProtKB-KW
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Cyp317a1 ORF Names:CG17453 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0033982, Cyp317a1 |
VEuPathDBi | VectorBase:FBgn0033982 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Peripheral membrane protein Curated
- Microsome membrane Curated; Peripheral membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000052330 | 1 – 518 | Probable cytochrome P450 317a1Add BLAST | 518 |
Proteomic databases
PaxDbi | Q9V776 |
Expressioni
Gene expression databases
Bgeei | FBgn0033982, Expressed in midgut and 27 other tissues |
ExpressionAtlasi | Q9V776, baseline and differential |
Genevisiblei | Q9V776, DM |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
HOGENOMi | CLU_001570_5_2_1 |
InParanoidi | Q9V776 |
PhylomeDBi | Q9V776 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9V776-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWIIFLIIGL LVLGLLVLLI IAARYQRDYW RYLDIPHERP KKLWPIIRQI
60 70 80 90 100
MTQTLSTEAM KAEHYSAIYK KFKGSGPFCG FYALLQPRAL ILDRELIRQI
110 120 130 140 150
MIKDFWNFND RGLYCNQKSD PLSGDLYALR GESWKEMRQK LDPSLEGDRM
160 170 180 190 200
SLLYDCLYEE AEQLLLTVNS TLMSQPHSTV HIQKIMRRYV LSSLAKCVFG
210 220 230 240 250
LNAEQRKTYP LEDFEQMTEL ALNSHKHGYL MNLMMIRFPN FCRMLRMRRT
260 270 280 290 300
PKQAEEYFIK LLTSIVEQRE TSGKPQKDYL QLLIDVKALE FITYQYEADK
310 320 330 340 350
ELGAHLQNEL AAHADVFLKA GYEQTANTLS YVLYELALHP ELQVRVREEV
360 370 380 390 400
KKAIERHDGH ITHEGIKSLS FMGQVINETL RMHPITPYIL RRTLNDYAVP
410 420 430 440 450
DHPKYILVKE LFLIIPTHAI HHDPDIYPDP EEFKPDRWSG PRDSLQEQGT
460 470 480 490 500
WFGFGVGARS CIGIQFAQLQ LRLALALLLS EYEFSLNTRK PLINLEDGIA
510
LTLMPLGVIE PGNEERAV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9QPG6 | C9QPG6_DROME | Cyp317a1, isoform B | Cyp317a1 317a1, Cyp317A1, Cyp317a1-RA, Dmel\CG17453, CG17453 | 518 | Annotation score: |
Sequence cautioni
The sequence AAF58184 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF58184.1 Sequence problems. |
RefSeqi | NP_001286435.1, NM_001299506.1 NP_001286436.1, NM_001299507.1 NP_611004.1, NM_137160.2 |
Genome annotation databases
GeneIDi | 36667 |
KEGGi | dme:Dmel_CG17453 |
UCSCi | CG17453-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF58184.1 Sequence problems. |
RefSeqi | NP_001286435.1, NM_001299506.1 NP_001286436.1, NM_001299507.1 NP_611004.1, NM_137160.2 |
3D structure databases
AlphaFoldDBi | Q9V776 |
SMRi | Q9V776 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7227.FBpp0086536 |
Proteomic databases
PaxDbi | Q9V776 |
Protocols and materials databases
DNASUi | 36667 |
Genome annotation databases
GeneIDi | 36667 |
KEGGi | dme:Dmel_CG17453 |
UCSCi | CG17453-RA, d. melanogaster |
Organism-specific databases
CTDi | 36667 |
FlyBasei | FBgn0033982, Cyp317a1 |
VEuPathDBi | VectorBase:FBgn0033982 |
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
HOGENOMi | CLU_001570_5_2_1 |
InParanoidi | Q9V776 |
PhylomeDBi | Q9V776 |
Miscellaneous databases
BioGRID-ORCSi | 36667, 0 hits in 1 CRISPR screen |
GenomeRNAii | 36667 |
PROi | PR:Q9V776 |
Gene expression databases
Bgeei | FBgn0033982, Expressed in midgut and 27 other tissues |
ExpressionAtlasi | Q9V776, baseline and differential |
Genevisiblei | Q9V776, DM |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP317_DROME | |
Accessioni | Q9V776Primary (citable) accession number: Q9V776 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | December 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families