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UniProtKB - Q9V773 (C6A20_DROME)
Protein
Probable cytochrome P450 6a20
Gene
Cyp6a20
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
By similarityCofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 445 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- monooxygenase activity Source: UniProtKB-KW
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
GO - Biological processi
- aggressive behavior Source: FlyBase
- defense response to Gram-negative bacterium Source: FlyBase
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Cyp6a20 ORF Names:CG10245 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0033980, Cyp6a20 |
VEuPathDBi | VectorBase:FBgn0033980 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Peripheral membrane protein Curated
- Microsome membrane Curated; Peripheral membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051874 | 1 – 501 | Probable cytochrome P450 6a20Add BLAST | 501 |
Proteomic databases
PaxDbi | Q9V773 |
PRIDEi | Q9V773 |
Expressioni
Gene expression databases
Bgeei | FBgn0033980, Expressed in antenna and 32 other tissues |
Genevisiblei | Q9V773, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 62406, 1 interactor |
IntActi | Q9V773, 1 interactor |
STRINGi | 7227.FBpp0289404 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
HOGENOMi | CLU_544664_0_0_1 |
InParanoidi | Q9V773 |
OMAi | WWVHQNF |
OrthoDBi | 467733at2759 |
PhylomeDBi | Q9V773 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9V773-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVMIVLLIG VITFVAWYVH QHFNYWKRRG IPHDEPKIPY GNTSELMKTV
60 70 80 90 100
HFADIFKRTY NKLRNKTDGP FVGFYMYFKR MVVVTDIDFA KTVLIREFDK
110 120 130 140 150
FHDRGVFHNE RDDPLSANLV NIDGQKWKTL RQKLTPTFTS GKMKTMFPTI
160 170 180 190 200
LTVGDELIRV FGETASADSD SMEITNVVAR FTADVIGSCA FGLDCHSLSD
210 220 230 240 250
PKAKFVQMGT TAITERRHGK SMDLLLFGAP ELAAKLRMKA TVQEVEDFYM
260 270 280 290 300
NIIRDTVDYR VKNNVKRHDF VDMLIEMKLK FDNGDKENGL TFNEIAAQAF
310 320 330 340 350
IFFLAGFETS STTMGFALYE LACHQDIQDK LRTEINTVLK QHNGKLDYDS
360 370 380 390 400
MREMTYLEKV IDETMRKRPV VGHLIRVATQ HYQHTNPKYN IEKGTGVIVP
410 420 430 440 450
TLAIHHDPEF YPEPEKFIPE RFDEDQVQQR PACTFLPFGD GPRNCIGLRF
460 470 480 490 500
GRMQVIVGMA LLIHNFKFEF HPTKTVVPLE YRTDDFLLSS KGGIHLKVTR
V
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 4 | M → L in AAL29138 (PubMed:12537569).Curated | 1 | |
Sequence conflicti | 4 | M → L in ACH92500 (Ref. 4) Curated | 1 | |
Sequence conflicti | 63 – 64 | LR → YK in AAL29138 (PubMed:12537569).Curated | 2 | |
Sequence conflicti | 63 – 64 | LR → YK in ACH92500 (Ref. 4) Curated | 2 | |
Sequence conflicti | 145 | T → N in AAL29138 (PubMed:12537569).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF58187.2 AY061590 mRNA Translation: AAL29138.2 BT044435 mRNA Translation: ACH92500.1 |
RefSeqi | NP_611002.3, NM_137158.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0300127; FBpp0289404; FBgn0033980 |
GeneIDi | 36664 |
KEGGi | dme:Dmel_CG10245 |
UCSCi | CG10245-RB, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF58187.2 AY061590 mRNA Translation: AAL29138.2 BT044435 mRNA Translation: ACH92500.1 |
RefSeqi | NP_611002.3, NM_137158.4 |
3D structure databases
AlphaFoldDBi | Q9V773 |
SMRi | Q9V773 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 62406, 1 interactor |
IntActi | Q9V773, 1 interactor |
STRINGi | 7227.FBpp0289404 |
Proteomic databases
PaxDbi | Q9V773 |
PRIDEi | Q9V773 |
Genome annotation databases
EnsemblMetazoai | FBtr0300127; FBpp0289404; FBgn0033980 |
GeneIDi | 36664 |
KEGGi | dme:Dmel_CG10245 |
UCSCi | CG10245-RB, d. melanogaster |
Organism-specific databases
CTDi | 36664 |
FlyBasei | FBgn0033980, Cyp6a20 |
VEuPathDBi | VectorBase:FBgn0033980 |
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
HOGENOMi | CLU_544664_0_0_1 |
InParanoidi | Q9V773 |
OMAi | WWVHQNF |
OrthoDBi | 467733at2759 |
PhylomeDBi | Q9V773 |
Miscellaneous databases
BioGRID-ORCSi | 36664, 0 hits in 3 CRISPR screens |
GenomeRNAii | 36664 |
PROi | PR:Q9V773 |
Gene expression databases
Bgeei | FBgn0033980, Expressed in antenna and 32 other tissues |
Genevisiblei | Q9V773, DM |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | C6A20_DROME | |
Accessioni | Q9V773Primary (citable) accession number: Q9V773 Secondary accession number(s): B5RJG1, Q95R69 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | December 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families