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UniProtKB - Q9V726 (CPSF1_DROME)

Entry version 138 (23 Feb 2022)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein

Cleavage and polyadenylation specificity factor subunit 1

Gene

Cpsf160

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mRNA 3'-UTR binding Source: FlyBase
  • myosin binding Source: FlyBase
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-DME-72163, mRNA Splicing - Major Pathway
R-DME-72187, mRNA 3'-end processing
R-DME-73856, RNA Polymerase II Transcription Termination
R-DME-77595, Processing of Intronless Pre-mRNAs

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9V726

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cleavage and polyadenylation specificity factor subunit 1
Alternative name(s):
Cleavage and polyadenylation specificity factor 160 kDa subunit
Short name:
CPSF 160 kDa subunit
Short name:
dCPSF 160
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cpsf160
Synonyms:cpsf
ORF Names:CG10110
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0024698, Cpsf160

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0024698

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000743891 – 1455Cleavage and polyadenylation specificity factor subunit 1Add BLAST1455

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9V726

PRoteomics IDEntifications database

More...PRIDEi		Q9V726

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0024698, Expressed in embryo and 37 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9V726, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of at least Clp, Cpsf73, Cpsf100 and Cpsf160.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		68918, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q9V726, 5 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0089163

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9V726

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CPSF1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1896, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183151

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002414_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9V726

Identification of Orthologs from Complete Genome Data

More...OMAi		PMTKFKL

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9V726

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004871, Cleavage/polyA-sp_fac_asu_C
IPR018846, Cleavage/polyA-sp_fac_asu_N
IPR015943, WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03178, CPSF_A, 1 hit
PF10433, MMS1_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: Q9V726-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFSMCKQTHS ATAVEFSIAC RFFNNLDENL VVAGANVLKV YRIAPNVEAS 
        60         70         80         90        100
QRQKLNPSEM RLAPKMRLEC LATYTLYGNV MSLQCVSLAG AMRDALLISF 
       110        120        130        140        150
KDAKLSVLQH DPDTFALKTL SLHYFEEDDI RGGWTGRYFV PTVRVDPDSR 
       160        170        180        190        200
CAVMLVYGKR LVVLPFRKDN SLDEIELADV KPIKKAPTAM VSRTPIMASY 
       210        220        230        240        250
LIALRDLDEK IDNVLDIQFL HGYYEPTLLI LYEPVRTCPG RIKVRSDTCV 
       260        270        280        290        300
LVAISLNIQQ RVHPIIWTVN SLPFDCLQVY PIQKPIGGCL VMTVNAVIYL 
       310        320        330        340        350
NQSVPPYGVS LNSSADNSTA FPLKPQDGVR ISLDCANFAF IDVDKLVISL 
       360        370        380        390        400
RTGDLYVLTL CVDSMRTVRN FHFHKAAASV LTSCICVLHS EYIFLGSRLG 
       410        420        430        440        450
NSLLLHFTEE DQSTVITLDE VEQQSEQQQR NLQDEDQNLE EIFDVDQLEM 
       460        470        480        490        500
APTQAKSRRI EDEELEVYGS GAKASVLQLR KFIFEVCDSL MNVAPINYMC 
       510        520        530        540        550
AGERVEFEED GVTLRPHAES LQDLKIELVA ATGHSKNGAL SVFVNCINPQ 
       560        570        580        590        600
IITSFELDGC LDVWTVFDDA TKKSSRNDQH DFMLLSQRNS TLVLQTGQEI 
       610        620        630        640        650
NEIENTGFTV NQPTIFVGNL GQQRFIVQVT TRHVRLLQGT RLIQNVPIDV 
       660        670        680        690        700
GSPVVQVSIA DPYVCLRVLN GQVITLALRE TRGTPRLAIN KHTISSSPAV 
       710        720        730        740        750
VAISAYKDLS GLFTVKGDDI NLTGSSNSAF GHSFGGYMKA EPNMKVEDEE 
       760        770        780        790        800
DLLYGDAGSA FKMNSMADLA KQSKQKNSDW WRRLLVQAKP SYWLVVARQS 
       810        820        830        840        850
GTLEIYSMPD MKLVYLVNDV GNGSMVLTDA MEFVPISLTT QENSKAGIVQ 
       860        870        880        890        900
ACMPQHANSP LPLELSVIGL GLNGERPLLL VRTRVELLIY QVFRYPKGHL 
       910        920        930        940        950
KIRFRKMDQL NLLDQQPTHI DLDENDEQEE IESYQMQPKY VQKLRPFANV 
       960        970        980        990       1000
GGLSGVMVCG VNPCFVFLTF RGELRIHRLL GNGDVRSFAA FNNVNIPNGF 
      1010       1020       1030       1040       1050
LYFDTTYELK ISVLPSYLSY DSVWPVRKVP LRCTPRQLVY HRENRVYCLI 
      1060       1070       1080       1090       1100
TQTEEPMTKY YRFNGEDKEL SEESRGERFI YPIGSQFEMV LISPETWEIV 
      1110       1120       1130       1140       1150
PDASITFEPW EHVTAFKIVK LSYEGTRSGL KEYLCIGTNF NYSEDITSRG 
      1160       1170       1180       1190       1200
NIHIYDIIEV VPEPGKPMTK FKIKEIFKKE QKGPVSAISD VLGFLVTGLG 
      1210       1220       1230       1240       1250
QKIYIWQLRD GDLIGVAFID TNIYVHQIIT VKSLIFIADV YKSISLLRFQ 
      1260       1270       1280       1290       1300
EEYRTLSLAS RDFNPLEVYG IEFMVDNSNL GFLVTDAERN IIVYMYQPEA 
      1310       1320       1330       1340       1350
RESLGGQKLL RKADYHLGQV VNTMFRVQCH QKGLHQRQPF LYENKHFVVY 
      1360       1370       1380       1390       1400
GTLDGALGYC LPLPEKVYRR FLMLQNVLLS YQEHLCGLNP KEYRTLKSSK 
      1410       1420       1430       1440       1450
KQGINPSRCI IDGDLIWSYR LMANSERNEV AKKIGTRTEE ILGDLLEIER 

LASVF
Length:1,455
Mass (Da):164,681
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB939D522310F479F
GO
Isoform B (identifier: Q9V726-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-278: Missing.

Show »
Length:1,420
Mass (Da):160,720
Checksum:i776BDEBEABB36D86
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti907M → L in AAF98388 (PubMed:9604891).Curated1
Sequence conflicti921D → E in AAF98388 (PubMed:9604891).Curated1
Sequence conflicti1076G → D in AAF98388 (PubMed:9604891).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001216244 – 278Missing in isoform B. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF241364 mRNA Translation: AAF98386.1
AF241365 mRNA Translation: AAF98387.1
AF241366 mRNA Translation: AAF98388.1
AE013599 Genomic DNA Translation: AAF58240.1
AE013599 Genomic DNA Translation: AAM68553.1
AY051896 mRNA Translation: AAK93320.1

NCBI Reference Sequences

More...RefSeqi		NP_725397.1, NM_166056.3 [Q9V726-2]
NP_995833.1, NM_206111.3 [Q9V726-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0089257; FBpp0088317; FBgn0024698 [Q9V726-2]
FBtr0089258; FBpp0089163; FBgn0024698 [Q9V726-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		44250

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG10110

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241364 mRNA Translation: AAF98386.1
AF241365 mRNA Translation: AAF98387.1
AF241366 mRNA Translation: AAF98388.1
AE013599 Genomic DNA Translation: AAF58240.1
AE013599 Genomic DNA Translation: AAM68553.1
AY051896 mRNA Translation: AAK93320.1
RefSeqiNP_725397.1, NM_166056.3 [Q9V726-2]
NP_995833.1, NM_206111.3 [Q9V726-1]

3D structure databases

SMRiQ9V726
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi68918, 4 interactors
IntActiQ9V726, 5 interactors
STRINGi7227.FBpp0089163

Proteomic databases

PaxDbiQ9V726
PRIDEiQ9V726

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		44250

Genome annotation databases

EnsemblMetazoaiFBtr0089257; FBpp0088317; FBgn0024698 [Q9V726-2]
FBtr0089258; FBpp0089163; FBgn0024698 [Q9V726-1]
GeneIDi44250
KEGGidme:Dmel_CG10110

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		44250
FlyBaseiFBgn0024698, Cpsf160
VEuPathDBiVectorBase:FBgn0024698

Phylogenomic databases

eggNOGiKOG1896, Eukaryota
GeneTreeiENSGT00950000183151
HOGENOMiCLU_002414_0_0_1
InParanoidiQ9V726
OMAiPMTKFKL
PhylomeDBiQ9V726

Enzyme and pathway databases

ReactomeiR-DME-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-DME-72163, mRNA Splicing - Major Pathway
R-DME-72187, mRNA 3'-end processing
R-DME-73856, RNA Polymerase II Transcription Termination
R-DME-77595, Processing of Intronless Pre-mRNAs
SignaLinkiQ9V726

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		44250, 1 hit in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		44250

Protein Ontology

More...PROi		PR:Q9V726

Gene expression databases

BgeeiFBgn0024698, Expressed in embryo and 37 other tissues
GenevisibleiQ9V726, DM

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR004871, Cleavage/polyA-sp_fac_asu_C
IPR018846, Cleavage/polyA-sp_fac_asu_N
IPR015943, WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF03178, CPSF_A, 1 hit
PF10433, MMS1_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCPSF1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9V726
Secondary accession number(s): Q7KR84
, Q960R9, Q9GV83, Q9GV84, Q9GV85
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2000
Last modified: February 23, 2022
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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