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Entry version 149 (16 Oct 2019)
Sequence version 2 (01 Oct 2002)
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Protein

Tripeptidyl-peptidase 2

Gene

TppII

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity). Efficiently cleaves Ala-Ala-Ala-polypeptide and Pro-Pro-Ala-polypeptide, Val-Leu-Lys-polypeptide only at high concentration. Does not cleave Ala-Phe-Pro-polypeptide nor Pro-Leu-Gly-polypeptide.By similarity

Miscellaneous

The limitation of proteolytic products to tripeptides is achieved by tailoring the size of the substrate-binding cleft: the two negatively charged residues Glu-399 and Glu-430 that are blocking position P4 limit the number of residues that can be accommodated in the binding cleft and thus create a molecular ruler. At the same time, they orient substrates so that the tripeptides are removed exclusively from the N-terminus (PubMed:20676100).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Release of an N-terminal tripeptide from a polypeptide.PROSITE-ProRule annotation1 Publication EC:3.4.14.10

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by phenylmethanesulfonyl fluoride (PMSF) and butabindide, but not by peptidase inhibitor pepstatin, EDTA, nor bestatin.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 7.5-7.8.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei131Charge relay systemPROSITE-ProRule annotation1 Publication1
Active sitei359Charge relay systemPROSITE-ProRule annotation1 Publication1
Active sitei549Charge relay systemPROSITE-ProRule annotation1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease, Serine protease

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9V6K1

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S08.090

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tripeptidyl-peptidase 2 (EC:3.4.14.10)
Short name:
TPP-2
Alternative name(s):
Tripeptidyl aminopeptidase
Tripeptidyl-peptidase II
Short name:
TPP-II
Short name:
dTPP II
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TppII
ORF Names:CG3991
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0020370 TppII

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000764251 – 1441Tripeptidyl-peptidase 2Add BLAST1441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1182Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9V6K1

PRoteomics IDEntifications database

More...
PRIDEi
Q9V6K1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9V6K1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0020370 Expressed in 50 organ(s), highest expression level in oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9V6K1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9V6K1 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer; forms a complex of 6 MDa probably composed of 40 subunits.

Forms a structure consisting of 2 segmented and twisted strands that form a spindle-shaped structure. Each strand is composed of 10 segments (a segment being a homodimer oriented head to head), stacking of these segments leads to the formation of a twisted single strand. 2 strands compose the fully assembled spindle.

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
62211, 7 interactors

Database of interacting proteins

More...
DIPi
DIP-59032N

Protein interaction database and analysis system

More...
IntActi
Q9V6K1, 8 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0086887

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11441
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9V6K1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini107 – 608Peptidase S8PROSITE-ProRule annotationAdd BLAST502

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S8 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1114 Eukaryota
COG1404 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014623

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9V6K1

KEGG Orthology (KO)

More...
KOi
K01280

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9V6K1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04857 Peptidases_S8_Tripeptidyl_Aminopeptidase_II, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.200, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR022229 Peptidase_S8A_TPPII
IPR022232 Peptidase_S8A_TPPII_art
IPR034051 TPP_II_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00082 Peptidase_S8, 1 hit
PF12580 TPPII, 1 hit
PF12583 TPPII_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00723 SUBTILISIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52743 SSF52743, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51892 SUBTILASE, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9V6K1-1) [UniParc]FASTAAdd to basket
Also known as: D

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFNRFRLVHK QLRLYKNFGL LGQKASVGLT LPIISLSRPY MAYMGTERSV
60 70 80 90 100
VMITAPATKE FAESSERSNS SKKTTNKEQS DKSAESRMAT SGIVESFPTG
110 120 130 140 150
ALVPKAETGV LNFLQKYPEY DGRDVTIAIF DSGVDPRATG LETLCDGKTV
160 170 180 190 200
KVIERYDCSG CGDVDMKKKV TPDENGNIKG LSGNSLKLSP ELMALNTDPE
210 220 230 240 250
KAVRVGLKSF SDLLPSKVRN NIVAQAKLKH WDKPHKTATA NASRKIVEFE
260 270 280 290 300
SQNPGEASKL PWDKKILKEN LDFELEMLNS YEKVYGDIKT SYDCILFPTA
310 320 330 340 350
DGWLTIVDTT EQGDLDQALR IGEYSRTHET RNVDDFLSIS VNVHDEGNVL
360 370 380 390 400
EVVGMSSPHG THVSSIASGN HSSRDVDGVA PNAKIVSMTI GDGRLGSMET
410 420 430 440 450
GTALVRAMTK VMELCRDGRR IDVINMSYGE HANWSNSGRI GELMNEVVNK
460 470 480 490 500
YGVVWVASAG NHGPALCTVG TPPDISQPSL IGVGAYVSPQ MMEAEYAMRE
510 520 530 540 550
KLPGNVYTWT SRDPCIDGGQ GVTVCAPGGA IASVPQFTMS KSQLMNGTSM
560 570 580 590 600
AAPHVAGAVA LLISGLKQQN IEYSPYSIKR AISVTATKLG YVDPFAQGHG
610 620 630 640 650
LLNVEKAFEH LTEHRQSKDN MLRFSVRVGN NADKGIHLRQ GVQRNSIDYN
660 670 680 690 700
VYIEPIFYND KEADPKDKFN FNVRLNLIAS QPWVQCGAFL DLSYGTRSIA
710 720 730 740 750
VRVDPTGLQP GVHSAVIRAY DTDCVQKGSL FEIPVTVVQP HVLESDQNTP
760 770 780 790 800
VFEPASSKGD NSVEFQPNTI QRDFILVPER ATWAELRMRI TDPNRGEDIG
810 820 830 840 850
KFFVHTNQLL PKQSCRKLET MKIVSVGSEN ESIMAFKVKS GRILELCIAK
860 870 880 890 900
YWSNYGQSHL KYSLRFRGVE AHNPNAYVMH AGRGIHKLEI EALVAEDVQP
910 920 930 940 950
QLQLKNAEVV LKPTEAKISP LSATRDVIPD GRQVYQNLLA FNLNVAKAAD
960 970 980 990 1000
VSIYAPIFND LLYEAEFESQ MWMLFDANKA LVATGDAHSH TSFTKLDKGE
1010 1020 1030 1040 1050
YTIRLQVRHE KRDLLEKISE ANLVASFKLT SPLTLDFYEN YNQCIVGGRK
1060 1070 1080 1090 1100
YVSSPLRLST RVLYIAPITQ ERLTKANLPA QCAWLSGNLV FPQDEVGRRV
1110 1120 1130 1140 1150
AQHPFTYILN PAEKKSHTNG SSNGSSAAGS TATAAAVTTA NGAKPKAPAT
1160 1170 1180 1190 1200
PQAATSVTNP AAGDGISVQN DPPVDSSGSP ASPKKGKANA DDYAESFRDF
1210 1220 1230 1240 1250
QCSQIVKCEL EMAEKIYNDV VAAHPKHLQA NLLLIQNIES NQLKSQLPLT
1260 1270 1280 1290 1300
FVNAQKTSPP EAGESADKQK EDQKKVRSAL ERIVKLADKV IQETDSEALL
1310 1320 1330 1340 1350
SYYGLKNDTR ADAAKIKTNM DKQKNTLIEA LSKKGIAVAK LAVLDDCIKD
1360 1370 1380 1390 1400
SLAEINELYT EIIKFVDAND SKAIQFALWH AYAHGHYGRM YKYVVKLIEE
1410 1420 1430 1440
KRTRDHFVEL AAINGALGHE HIRTVINRMM ITAFPSSFRL F
Length:1,441
Mass (Da):158,737
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD71CF8558BE30922
GO
Isoform 2 (identifier: Q9V6K1-2) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.

Show »
Length:1,354
Mass (Da):148,909
Checksum:i525E1FCD6D7CB819
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4LGC0A0A0B4LGC0_DROME
Tripeptidyl-peptidase II, isoform F
TppII anon-WO0118547.127, Dmel\CG3991, dTPP II, dTPPII, l(2)k14301
1,354Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4LF88A0A0B4LF88_DROME
Tripeptidyl-peptidase II, isoform E
TppII anon-WO0118547.127, Dmel\CG3991, dTPP II, dTPPII, l(2)k14301
1,375Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti103V → M in AAN71159 (PubMed:12537569).Curated1
Sequence conflicti1377A → G in AAC28563 (PubMed:9668104).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0152201 – 87Missing in isoform 2. 2 PublicationsAdd BLAST87

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF035251 mRNA Translation: AAC28563.1
AE013599 Genomic DNA Translation: AAF58422.2
AE013599 Genomic DNA Translation: AAM68593.1
BT001404 mRNA Translation: AAN71159.1
BT003260 mRNA Translation: AAO25017.1
BT044288 mRNA Translation: ACH92353.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T13930

NCBI Reference Sequences

More...
RefSeqi
NP_001286376.1, NM_001299447.1 [Q9V6K1-2]
NP_477247.1, NM_057899.3 [Q9V6K1-2]
NP_725252.1, NM_165966.2 [Q9V6K1-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087774; FBpp0086887; FBgn0020370 [Q9V6K1-1]
FBtr0087775; FBpp0086888; FBgn0020370 [Q9V6K1-2]
FBtr0344199; FBpp0310608; FBgn0020370 [Q9V6K1-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36444

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG3991

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035251 mRNA Translation: AAC28563.1
AE013599 Genomic DNA Translation: AAF58422.2
AE013599 Genomic DNA Translation: AAM68593.1
BT001404 mRNA Translation: AAN71159.1
BT003260 mRNA Translation: AAO25017.1
BT044288 mRNA Translation: ACH92353.1
PIRiT13930
RefSeqiNP_001286376.1, NM_001299447.1 [Q9V6K1-2]
NP_477247.1, NM_057899.3 [Q9V6K1-2]
NP_725252.1, NM_165966.2 [Q9V6K1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LXUX-ray3.14X88-1441[»]
SMRiQ9V6K1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi62211, 7 interactors
DIPiDIP-59032N
IntActiQ9V6K1, 8 interactors
STRINGi7227.FBpp0086887

Protein family/group databases

MEROPSiS08.090

PTM databases

iPTMnetiQ9V6K1

Proteomic databases

PaxDbiQ9V6K1
PRIDEiQ9V6K1

Genome annotation databases

EnsemblMetazoaiFBtr0087774; FBpp0086887; FBgn0020370 [Q9V6K1-1]
FBtr0087775; FBpp0086888; FBgn0020370 [Q9V6K1-2]
FBtr0344199; FBpp0310608; FBgn0020370 [Q9V6K1-2]
GeneIDi36444
KEGGidme:Dmel_CG3991

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
36444
FlyBaseiFBgn0020370 TppII

Phylogenomic databases

eggNOGiKOG1114 Eukaryota
COG1404 LUCA
GeneTreeiENSGT00390000014623
InParanoidiQ9V6K1
KOiK01280
PhylomeDBiQ9V6K1

Enzyme and pathway databases

ReactomeiR-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ9V6K1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TppII fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
36444

Protein Ontology

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PROi
PR:Q9V6K1

Gene expression databases

BgeeiFBgn0020370 Expressed in 50 organ(s), highest expression level in oocyte
ExpressionAtlasiQ9V6K1 baseline and differential
GenevisibleiQ9V6K1 DM

Family and domain databases

CDDicd04857 Peptidases_S8_Tripeptidyl_Aminopeptidase_II, 1 hit
Gene3Di3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR022229 Peptidase_S8A_TPPII
IPR022232 Peptidase_S8A_TPPII_art
IPR034051 TPP_II_domain
PfamiView protein in Pfam
PF00082 Peptidase_S8, 1 hit
PF12580 TPPII, 1 hit
PF12583 TPPII_N, 1 hit
PRINTSiPR00723 SUBTILISIN
SUPFAMiSSF52743 SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS51892 SUBTILASE, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPP2_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9V6K1
Secondary accession number(s): B5RJ14
, O76251, Q8IH59, Q8ML58
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2002
Last modified: October 16, 2019
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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