UniProtKB - Q9V668 (S61G1_DROME)
Protein
Protein transport protein Sec61 gamma-1 subunit
Gene
SEC61G1
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Necessary for protein translocation in the endoplasmic reticulum.By similarity
GO - Molecular functioni
- P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro
- protein transmembrane transporter activity Source: GO_Central
GO - Biological processi
- posttranslational protein targeting to membrane, translocation Source: GO_Central
- SRP-dependent cotranslational protein targeting to membrane, translocation Source: FlyBase
Keywordsi
Biological process | Protein transport, Translocation, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Protein transport protein Sec61 gamma-1 subunit |
Gene namesi | Name:SEC61G1 ORF Names:CG8860 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0033691, CG8860 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Single-pass membrane protein Curated
Endoplasmic reticulum
- Sec61 translocon complex Source: FlyBase
- Ssh1 translocon complex Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 32 | CytoplasmicSequence analysisAdd BLAST | 32 | |
Transmembranei | 33 – 61 | HelicalSequence analysisAdd BLAST | 29 | |
Topological domaini | 62 – 68 | ExtracellularSequence analysis | 7 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000104202 | 1 – 68 | Protein transport protein Sec61 gamma-1 subunitAdd BLAST | 68 |
Proteomic databases
PaxDbi | Q9V668 |
PRIDEi | Q9V668 |
Expressioni
Gene expression databases
Bgeei | FBgn0033691, Expressed in larva and 18 other tissues |
ExpressionAtlasi | Q9V668, baseline and differential |
Genevisiblei | Q9V668, DM |
Interactioni
Subunit structurei
Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.
By similarityProtein-protein interaction databases
BioGRIDi | 62091, 2 interactors |
STRINGi | 7227.FBpp0087119 |
Family & Domainsi
Sequence similaritiesi
Belongs to the SecE/SEC61-gamma family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3498, Eukaryota |
GeneTreei | ENSGT00390000001319 |
HOGENOMi | CLU_167752_2_0_1 |
InParanoidi | Q9V668 |
OMAi | RDGNQFL |
OrthoDBi | 1623399at2759 |
PhylomeDBi | Q9V668 |
Family and domain databases
Gene3Di | 1.20.5.820, 1 hit |
HAMAPi | MF_00422, SecE, 1 hit |
InterProi | View protein in InterPro IPR023391, Prot_translocase_SecE_dom_sf IPR008158, Translocase_Sec61-g IPR001901, Translocase_SecE/Sec61-g |
Pfami | View protein in Pfam PF00584, SecE, 1 hit |
SUPFAMi | SSF103456, SSF103456, 1 hit |
TIGRFAMsi | TIGR00327, secE_euk_arch, 1 hit |
PROSITEi | View protein in PROSITE PS01067, SECE_SEC61G, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9V668-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDKVVKFAEP GRAFAKDSIR LVKRCTKPDR KEFQKIAIAT AVGFAIMGFI
60
GFFVKLIHIP INNIIVGS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF58563.1 AY118846 mRNA Translation: AAM50706.1 |
RefSeqi | NP_610738.1, NM_136894.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0088011; FBpp0087119; FBgn0033691 |
GeneIDi | 36310 |
KEGGi | dme:Dmel_CG8860 |
UCSCi | CG8860-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF58563.1 AY118846 mRNA Translation: AAM50706.1 |
RefSeqi | NP_610738.1, NM_136894.3 |
3D structure databases
SMRi | Q9V668 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 62091, 2 interactors |
STRINGi | 7227.FBpp0087119 |
Proteomic databases
PaxDbi | Q9V668 |
PRIDEi | Q9V668 |
Genome annotation databases
EnsemblMetazoai | FBtr0088011; FBpp0087119; FBgn0033691 |
GeneIDi | 36310 |
KEGGi | dme:Dmel_CG8860 |
UCSCi | CG8860-RA, d. melanogaster |
Organism-specific databases
FlyBasei | FBgn0033691, CG8860 |
Phylogenomic databases
eggNOGi | KOG3498, Eukaryota |
GeneTreei | ENSGT00390000001319 |
HOGENOMi | CLU_167752_2_0_1 |
InParanoidi | Q9V668 |
OMAi | RDGNQFL |
OrthoDBi | 1623399at2759 |
PhylomeDBi | Q9V668 |
Miscellaneous databases
BioGRID-ORCSi | 36310, 0 hits in 1 CRISPR screen |
ChiTaRSi | CG8860, fly |
GenomeRNAii | 36310 |
PROi | PR:Q9V668 |
Gene expression databases
Bgeei | FBgn0033691, Expressed in larva and 18 other tissues |
ExpressionAtlasi | Q9V668, baseline and differential |
Genevisiblei | Q9V668, DM |
Family and domain databases
Gene3Di | 1.20.5.820, 1 hit |
HAMAPi | MF_00422, SecE, 1 hit |
InterProi | View protein in InterPro IPR023391, Prot_translocase_SecE_dom_sf IPR008158, Translocase_Sec61-g IPR001901, Translocase_SecE/Sec61-g |
Pfami | View protein in Pfam PF00584, SecE, 1 hit |
SUPFAMi | SSF103456, SSF103456, 1 hit |
TIGRFAMsi | TIGR00327, secE_euk_arch, 1 hit |
PROSITEi | View protein in PROSITE PS01067, SECE_SEC61G, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S61G1_DROME | |
Accessioni | Q9V668Primary (citable) accession number: Q9V668 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2003 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families