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Protein

Aquaporin

Gene

Drip

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Forms a water-specific channel.By similarity

GO - Molecular functioni

  • water channel activity Source: FlyBase

GO - Biological processi

  • ion transmembrane transport Source: GO_Central
  • regulation of oviposition Source: FlyBase
  • renal system process Source: FlyBase
  • transmembrane transport Source: FlyBase
  • water homeostasis Source: FlyBase
  • water transport Source: FlyBase

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-DME-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-DME-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-DME-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-DME-432047 Passive transport by Aquaporins

Protein family/group databases

TCDBi1.A.8.8.13 the major intrinsic protein (mip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin
Gene namesi
Name:Drip
ORF Names:CG9023
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0015872 Drip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
Transmembranei27 – 46Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini47 – 51ExtracellularSequence analysis5
Transmembranei52 – 72Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini73 – 94CytoplasmicSequence analysisAdd BLAST22
Transmembranei95 – 115Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini116 – 132ExtracellularSequence analysisAdd BLAST17
Transmembranei133 – 153Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini154 – 163CytoplasmicSequence analysis10
Transmembranei164 – 184Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini185 – 205ExtracellularSequence analysisAdd BLAST21
Transmembranei206 – 226Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini227 – 245CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639761 – 245AquaporinAdd BLAST245

Proteomic databases

PaxDbiQ9V5Z7
PRIDEiQ9V5Z7

Expressioni

Gene expression databases

BgeeiFBgn0015872
ExpressionAtlasiQ9V5Z7 baseline and differential
GenevisibleiQ9V5Z7 DM

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi62024, 1 interactor
DIPiDIP-23832N
IntActiQ9V5Z7, 1 interactor
STRINGi7227.FBpp0303808

Structurei

3D structure databases

ProteinModelPortaliQ9V5Z7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi76 – 78NPA 13
Motifi192 – 194NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223 Eukaryota
COG0580 LUCA
GeneTreeiENSGT00760000119223
InParanoidiQ9V5Z7
KOiK09884
OrthoDBiEOG091G166T
PhylomeDBiQ9V5Z7

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
TIGRFAMsiTIGR00861 MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9V5Z7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEKTEMSKF VGVADITENK KIWRMLLGEL VGTFFLIFVG VGSTTSGSVP
60 70 80 90 100
QIAFTFGLTV ATIAQGLGHL SGCHINPAVT LGFLIVGEIS ILKAAFYIIV
110 120 130 140 150
QCVGAIAGAA VIKVALDGVA GGDLGVSSFD PSLNCAQAVL IEALITFILV
160 170 180 190 200
FVVKAVSDPG RQDIKGSAPL AVGLAIAAGH LCAIKLSGAS MNPARSFGPA
210 220 230 240
VVQGVWTYHW VYWVGPIAGG LLAGIIYRLI FKVRKGDDET DSYDF
Length:245
Mass (Da):25,575
Last modified:October 1, 2002 - v2
Checksum:i611AA17CFE3B807C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122 – 129GDLGVSSF → ATWSILL in AAA81324 (Ref. 4) Curated8
Sequence conflicti191M → T in AAA81324 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58643.2
AE013599 Genomic DNA Translation: AAM68740.2
BT023883 mRNA Translation: ABA81817.1
U38807 mRNA Translation: AAA81324.1
RefSeqiNP_523697.1, NM_078973.3
NP_725051.2, NM_165833.3
UniGeneiDm.16162

Genome annotation databases

EnsemblMetazoaiFBtr0088141; FBpp0087240; FBgn0015872
FBtr0088142; FBpp0087241; FBgn0015872
GeneIDi36236
KEGGidme:Dmel_CG9023

Similar proteinsi

Entry informationi

Entry nameiAQP_DROME
AccessioniPrimary (citable) accession number: Q9V5Z7
Secondary accession number(s): Q24148, Q3KN56, Q8MKY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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