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Entry version 153 (10 Feb 2021)
Sequence version 4 (05 Jul 2004)
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Protein

Longitudinals lacking protein, isoforms J/P/Q/S/Z

Gene

lola

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri849 – 871C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri878 – 901C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA-binding transcription factor activity Source: FlyBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Longitudinals lacking protein, isoforms J/P/Q/S/Z
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lolaImported
ORF Names:CG12052Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0283521, lola

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi107A → V in ORE120; defective in embryonic axon guidance. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000470761 – 963Longitudinals lacking protein, isoforms J/P/Q/S/ZAdd BLAST963

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

By stage 11, isoform Q, isoform P and isoform Z are expressed throughout the mesoderm. From stage 15, expression of isoform P expands to all tissues, whereas expression of isoform Z and isoform Q becomes restricted during later stages; starting from stage 14 to 16, isoform Z is expressed in muscle, and isoform Q and isoform Z are expressed in the CNS. For some isoforms, expression is also seen in specific types of cells in the embryo; isoform Z is expressed in the ventral furrow at stage 5, and isoform Q is expressed around the tracheal pits at stage 11. Isoform Z also shows transient enrichment in a dorsal cell layer in the CNS at stages 13 and 14.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically. At least one isoform is present at each developmental stage.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0005630, Expressed in cleaving embryo and 38 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9V5M6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9V5M6, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
69126, 48 interactors

Protein interaction database and analysis system

More...
IntActi
Q9V5M6, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9V5M6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 97BTBPROSITE-ProRule annotationAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi527 – 546Ala-richSequence analysisAdd BLAST20
Compositional biasi731 – 756Gln-richSequence analysisAdd BLAST26

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri849 – 871C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri878 – 901C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000174551

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010740_2_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
RRHMRKE

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000210, BTB/POZ_dom
IPR011333, SKP1/BTB/POZ_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00651, BTB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00225, BTB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54695, SSF54695, 1 hit
SSF57667, SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097, BTB, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (22)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 22 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Some isoforms may be generated by alternative trans-splicing of exons sequentially encoded by the same DNA strand.
Isoform P1 Publication (identifier: Q9V5M6-1) [UniParc]FASTAAdd to basket
Also known as: Ohsako-N1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDDQQFCLR WNNHQSTLIS VFDTLLENET LVDCTLAAEG KFLKAHKVVL
60 70 80 90 100
SACSPYFATL LQEQYDKHPI FILKDVKYQE LRAMMDYMYR GEVNISQDQL
110 120 130 140 150
AALLKAAESL QIKGLSDNRT GGGVAPKPES SGHHRGGKLS GAYTLEQTKR
160 170 180 190 200
ARLATGGAMD TSGDVSGSRE GSSSPSRRRR KVRRRSMEND AHDNSNSSVL
210 220 230 240 250
QAAASNQSIL QQTGAGLAVS ALVTTQLSSG PAAGTSSQAS STQQQQPLTS
260 270 280 290 300
TNVTKKTESA KLTSSTAAPA SGASASAAVQ QAHLHQQQAQ TTSDAINTEN
310 320 330 340 350
VQAQSQGGAQ GVQGDDEDID EGSAVGGPNS ATGPNPASAS ASAVHAGVVV
360 370 380 390 400
KQLASVVDKS SSNHKHKIKD NSVSSVGSEM VIEPKAEYDD DAHDENVEDL
410 420 430 440 450
TLDEEDMTME ELDQTAGTSQ GGEGSSQTYA TWQHDRSQDE LGLMAQDAQQ
460 470 480 490 500
RDPQDEAGQN EGGESRIRVR NWLMLADKSI IGKSSDEPSD KLTQSKKSLI
510 520 530 540 550
SDAKTTNKTS TPIRPKVSTT TTSTSTAAAA AAAATIAAKQ AAAAIASSNI
560 570 580 590 600
NNNNSSLTQT VTQTVTRIGS IGRTTIACIT PANNGNKSSS SNCNVDAASA
610 620 630 640 650
AALAAAGVEL DSIDDTMTEV IVKIENPESM PLNDDEDDAV CNEAIEDENT
660 670 680 690 700
FDYDLKLGSP LSWTYDAVKI ENEEFEDSYL MDNDDDDDDL LTTAAATQKH
710 720 730 740 750
AKQSNEKQMA GSMVAGAGSG GAVKKIVLSA QQQQQLLEQQ QHLQHLQLQP
760 770 780 790 800
TSQSLQIKLP AIPATITTIS APKQMMSGAG TSGSLTPNNN CTLMSNKLGL
810 820 830 840 850
PVKGQNLDLH WSHSDDNRYR VLVQNKRTRK ESLEHSADMI YNADIEKPWV
860 870 880 890 900
CRNCNRTYKW KNSLKCHLKN ECGLPPRYFC SKMCGYATNV HSNLKRHLNT
910 920 930 940 950
KCRDREKDAD DEKKPGSASG NMPVVVGVGN GTAVPVSSSN NNNNGGGSST
960
SSTYTLVFQN DSA
Length:963
Mass (Da):102,734
Last modified:July 5, 2004 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i850960B2AFDD577C
GO
Isoform J1 Publication (identifier: Q9V5M6-2) [UniParc]FASTAAdd to basket
Also known as: Ohsako-O1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     455-757: DEAGQNEGGE...LQPTSQSLQI → DFGRLSPNRR...VLHMRTHQHR
     758-963: Missing.

Show »
Length:757
Mass (Da):78,690
Checksum:iB0B8DC000576D61D
GO
Isoform Q1 Publication (identifier: Q9V5M6-3) [UniParc]FASTAAdd to basket
Also known as: Ohsako-B1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     455-603: DEAGQNEGGE...NVDAASAAAL → DSMVVPKITA...YVHKGVQKRE
     604-963: Missing.

Show »
Length:603
Mass (Da):64,685
Checksum:iD6571AA7AB6DEEAF
GO
Isoform S1 Publication (identifier: Q9V5M6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-720: DEAGQNEGGE...GSMVAGAGSG → ARTQHEHIHT...KHGIHQLKKV
     721-963: Missing.

Show »
Length:720
Mass (Da):77,050
Checksum:i5E2CDD847299CC6E
GO
Isoform Z (identifier: Q9V5M6-5) [UniParc]FASTAAdd to basket
Also known as: Ohsako-E

The sequence of this isoform differs from the canonical sequence as follows:
     456-665: EAGQNEGGES...KLGSPLSWTY → LRTLYCNYAT...KHGIHQLKKV
     666-963: Missing.

Show »
Length:665
Mass (Da):70,896
Checksum:iC6A194CE379E3358
GO
Isoform A1 Publication (identifier: Q7KQZ4-2) [UniParc]FASTAAdd to basket
Also known as: Ohsako-D1 Publication
The sequence of this isoform can be found in the external entry Q7KQZ4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:706
Mass (Da):75,751
GO
Isoform B (identifier: Q7KQZ4-1) [UniParc]FASTAAdd to basket
Also known as: C1 Publication, Ohsako-L1 Publication
The sequence of this isoform can be found in the external entry Q7KQZ4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:787
Mass (Da):82,173
GO
Isoform D1 Publication (identifier: Q7KQZ4-3) [UniParc]FASTAAdd to basket
Also known as: E, Ohsako-F1 Publication
The sequence of this isoform can be found in the external entry Q7KQZ4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:748
Mass (Da):79,439
GO
Isoform F1 Publication (identifier: Q867Z4-2) [UniParc]FASTAAdd to basket
Also known as: Ohsako-I1 Publication
The sequence of this isoform can be found in the external entry Q867Z4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:565
Mass (Da):60,740
GO
Isoform G1 Publication (identifier: P42283-1) [UniParc]FASTAAdd to basket
Also known as: Long1 Publication, Ohsako-T1 Publication, R
The sequence of this isoform can be found in the external entry P42283.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:891
Mass (Da):96,254
GO
Isoform H1 Publication (identifier: P42284-3) [UniParc]FASTAAdd to basket
Also known as: Ohsako-M1 Publication
The sequence of this isoform can be found in the external entry P42284.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:518
Mass (Da):55,409
GO
Isoform I1 Publication (identifier: Q867Z4-1) [UniParc]FASTAAdd to basket
Also known as: Ohsako-K1 Publication
The sequence of this isoform can be found in the external entry Q867Z4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:970
Mass (Da):105,812
GO
Isoform K1 Publication (identifier: Q867Z4-3) [UniParc]FASTAAdd to basket
Also known as: Ohsako-H1 Publication
The sequence of this isoform can be found in the external entry Q867Z4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:546
Mass (Da):58,945
GO
Isoform L1 Publication (identifier: Q7KQZ4-4) [UniParc]FASTAAdd to basket
Also known as: Ohsako-C1 Publication
The sequence of this isoform can be found in the external entry Q7KQZ4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:608
Mass (Da):65,412
GO
Isoform M1 Publication (identifier: P42284-1) [UniParc]FASTAAdd to basket
Also known as: Short1 Publication, Ohsako-A1 Publication
The sequence of this isoform can be found in the external entry P42284.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:465
Mass (Da):49,320
GO
Isoform N1 Publication (identifier: Q9V5M3-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9V5M3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:878
Mass (Da):96,207
GO
Isoform O1 Publication (identifier: Q9V5M3-2) [UniParc]FASTAAdd to basket
Also known as: Ohsako-P1 Publication
The sequence of this isoform can be found in the external entry Q9V5M3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:668
Mass (Da):71,801
GO
Isoform T1 Publication (identifier: Q867Z4-5) [UniParc]FASTAAdd to basket
Also known as: U1 Publication, Ohsako-J1 Publication
The sequence of this isoform can be found in the external entry Q867Z4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:575
Mass (Da):61,917
GO
Isoform V1 Publication (identifier: P42284-2) [UniParc]FASTAAdd to basket
Also known as: Ohsako-G1 Publication
The sequence of this isoform can be found in the external entry P42284.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:549
Mass (Da):59,323
GO
Isoform W1 Publication (identifier: Q9V5M3-3) [UniParc]FASTAAdd to basket
Also known as: Ohsako-Q1 Publication
The sequence of this isoform can be found in the external entry Q9V5M3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:771
Mass (Da):83,526
GO
Isoform X1 Publication (identifier: Q9V5M3-4) [UniParc]FASTAAdd to basket
Also known as: Ohsako-S1 Publication
The sequence of this isoform can be found in the external entry Q9V5M3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:602
Mass (Da):64,422
GO
Isoform Y1 Publication (identifier: Q9V5M3-5) [UniParc]FASTAAdd to basket
Also known as: Ohsako-R1 Publication
The sequence of this isoform can be found in the external entry Q9V5M3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:577
Mass (Da):62,746
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti115L → F in ABJ17042 (Ref. 4) Curated1
Isoform Z (identifier: Q9V5M6-5)
Sequence conflicti475S → N in BAC67601 (PubMed:12853139).Curated1
Sequence conflicti475S → N in BAC67621 (PubMed:12853139).Curated1
Sequence conflicti475S → N in BAC67641 (PubMed:12853139).Curated1
Sequence conflicti549M → V in BAC67601 (PubMed:12853139).Curated1
Sequence conflicti549M → V in BAC67621 (PubMed:12853139).Curated1
Sequence conflicti549M → V in BAC67641 (PubMed:12853139).Curated1
Sequence conflicti626A → V in BAC67601 (PubMed:12853139).Curated1
Sequence conflicti626A → V in BAC67621 (PubMed:12853139).Curated1
Sequence conflicti626A → V in BAC67641 (PubMed:12853139).Curated1
Isoform Q1 Publication (identifier: Q9V5M6-3)
Sequence conflicti477A → G in BAC67578 (PubMed:12853139).Curated1
Sequence conflicti477A → G in BAC67598 (PubMed:12853139).Curated1
Sequence conflicti477A → G in BAC67618 (PubMed:12853139).Curated1
Sequence conflicti477A → G in BAC67638 (PubMed:12853139).Curated1
Sequence conflicti485M → I in BAC67578 (PubMed:12853139).Curated1
Sequence conflicti485M → I in BAC67598 (PubMed:12853139).Curated1
Sequence conflicti485M → I in BAC67618 (PubMed:12853139).Curated1
Sequence conflicti485M → I in BAC67638 (PubMed:12853139).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_051809455 – 757DEAGQ…QSLQI → DFGRLSPNRRNYNLLGGIKS SPYNSPIGTPVIKFEPGSGQ EDHNEHKSGRVTPTAHCPGN LLVPKTQPRHGNGDNDDSND EDSMEPCDLRIDLAKAFLAA AQSGAATTLPLGHHHHHGHH PHGRTLPNLIYPAVPVKVPR PDTPTRRYSSSSGPVQDAAS SVAVQFVAAAAAAGLAANNT SASTNTGGGASTSAAAAAAA AAAAAAAAAAAGGSVAGNWS SGGGSGGAGGGIGGGGSGGG GGGGGGGAYACDRCGNTYAR PHSLNRHVRFECGVEPKFEC PICHKKSKHKHNLVLHMRTH QHR in isoform J. 1 PublicationAdd BLAST303
Alternative sequenceiVSP_017255455 – 720DEAGQ…GAGSG → ARTQHEHIHTTPPAISLFLN STTPYFDSLSLSVLSVRIVK QSQQILDKNPITILTDLRTL YCNYATAVIAAASAASKKPA EHQTAASSTANHQNQNLNHQ NLLQQHHSNSSSNSNCGPAA EICEPEVTIRRMFKCGNSGQ AEAIVNHLQMTGQQHQQLHC NVSNCSGCHMSAAAASFQLA NLLNSGIRSSSTSKPQRNHI SASGNTSSSSNANTNNNSSG NSSLSLAAKKTSVQFHCEFC NFSCSWRYDLKLHLRQKHGI HQLKKV in isoform S. CuratedAdd BLAST266
Alternative sequenceiVSP_051807455 – 603DEAGQ…SAAAL → DSMVVPKITAVRGSSKRLAR RKATLAIATAMATSASATHM MSRRKRTSSSCRNASSGGNA PSTSTSASSATTASISKSKC KSSDAASAPFVCQTCGRRYQ VLGTLRRHMRKECNQPKKYV CRMCERRFHYNFKLQDHYYY VHKGVQKRE in isoform Q. 1 PublicationAdd BLAST149
Alternative sequenceiVSP_051808456 – 665EAGQN…LSWTY → LRTLYCNYATAVIAAASAAS KKPAEHQTAASSTANHQNQN LNHQNLLQQHHSNSSSNSNC GPAAEICEPEVTIRRMFKCG NSGQAEAIVNHLQMTGQQHQ QLHCNVSNCSGCHMSAAAAS FQLANLLNSGIRSSSTSKPQ RNHISASGNTSSSSNANTNN NSSGNSSLSLAAKKTSVQFH CEFCNFSCSWRYDLKLHLRQ KHGIHQLKKV in isoform Z. 1 PublicationAdd BLAST210
Alternative sequenceiVSP_051810604 – 963Missing in isoform Q. 1 PublicationAdd BLAST360
Alternative sequenceiVSP_051811666 – 963Missing in isoform Z. 1 PublicationAdd BLAST298
Alternative sequenceiVSP_017256721 – 963Missing in isoform S. CuratedAdd BLAST243
Alternative sequenceiVSP_051812758 – 963Missing in isoform J. 1 PublicationAdd BLAST206

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB107273 mRNA Translation: BAC67578.1
AB107276 mRNA Translation: BAC67581.1
AB107285 mRNA Translation: BAC67590.1
AB107286 mRNA Translation: BAC67591.1
AB107293 mRNA Translation: BAC67598.1
AB107296 mRNA Translation: BAC67601.1
AB107305 mRNA Translation: BAC67610.1
AB107306 mRNA Translation: BAC67611.1
AB107313 mRNA Translation: BAC67618.1
AB107316 mRNA Translation: BAC67621.1
AB107325 mRNA Translation: BAC67630.1
AB107326 mRNA Translation: BAC67631.1
AB107333 mRNA Translation: BAC67638.1
AB107336 mRNA Translation: BAC67641.1
AB107345 mRNA Translation: BAC67650.1
AB107346 mRNA Translation: BAC67651.1
AE013599 Genomic DNA Translation: AAF58778.4
AE013599 Genomic DNA Translation: AAF58779.3
AE013599 Genomic DNA Translation: AAM68768.2
AE013599 Genomic DNA Translation: AAO41429.1
AE013599 Genomic DNA Translation: AAZ52818.1
BT029109 mRNA Translation: ABJ17042.1

NCBI Reference Sequences

More...
RefSeqi
NP_001027400.1, NM_001032229.3 [Q9V5M6-5]
NP_788310.2, NM_176130.5 [Q9V5M6-2]
NP_788311.2, NM_176131.5 [Q9V5M6-1]
NP_788319.1, NM_176139.3 [Q9V5M6-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0089355; FBpp0088389; FBgn0283521 [Q9V5M6-1]
FBtr0089356; FBpp0088390; FBgn0283521 [Q9V5M6-3]
FBtr0089360; FBpp0088394; FBgn0283521 [Q9V5M6-2]
FBtr0100286; FBpp0099680; FBgn0283521 [Q9V5M6-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
44548

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB107273 mRNA Translation: BAC67578.1
AB107276 mRNA Translation: BAC67581.1
AB107285 mRNA Translation: BAC67590.1
AB107286 mRNA Translation: BAC67591.1
AB107293 mRNA Translation: BAC67598.1
AB107296 mRNA Translation: BAC67601.1
AB107305 mRNA Translation: BAC67610.1
AB107306 mRNA Translation: BAC67611.1
AB107313 mRNA Translation: BAC67618.1
AB107316 mRNA Translation: BAC67621.1
AB107325 mRNA Translation: BAC67630.1
AB107326 mRNA Translation: BAC67631.1
AB107333 mRNA Translation: BAC67638.1
AB107336 mRNA Translation: BAC67641.1
AB107345 mRNA Translation: BAC67650.1
AB107346 mRNA Translation: BAC67651.1
AE013599 Genomic DNA Translation: AAF58778.4
AE013599 Genomic DNA Translation: AAF58779.3
AE013599 Genomic DNA Translation: AAM68768.2
AE013599 Genomic DNA Translation: AAO41429.1
AE013599 Genomic DNA Translation: AAZ52818.1
BT029109 mRNA Translation: ABJ17042.1
RefSeqiNP_001027400.1, NM_001032229.3 [Q9V5M6-5]
NP_788310.2, NM_176130.5 [Q9V5M6-2]
NP_788311.2, NM_176131.5 [Q9V5M6-1]
NP_788319.1, NM_176139.3 [Q9V5M6-3]

3D structure databases

SMRiQ9V5M6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi69126, 48 interactors
IntActiQ9V5M6, 1 interactor

Genome annotation databases

EnsemblMetazoaiFBtr0089355; FBpp0088389; FBgn0283521 [Q9V5M6-1]
FBtr0089356; FBpp0088390; FBgn0283521 [Q9V5M6-3]
FBtr0089360; FBpp0088394; FBgn0283521 [Q9V5M6-2]
FBtr0100286; FBpp0099680; FBgn0283521 [Q9V5M6-5]
GeneIDi44548

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
44548
FlyBaseiFBgn0283521, lola

Phylogenomic databases

GeneTreeiENSGT00940000174551
HOGENOMiCLU_010740_2_0_1
OMAiRRHMRKE

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
44548, 1 hit in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
lola, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
44548

Gene expression databases

BgeeiFBgn0005630, Expressed in cleaving embryo and 38 other tissues
ExpressionAtlasiQ9V5M6, baseline and differential
GenevisibleiQ9V5M6, DM

Family and domain databases

InterProiView protein in InterPro
IPR000210, BTB/POZ_dom
IPR011333, SKP1/BTB/POZ_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00651, BTB, 1 hit
SMARTiView protein in SMART
SM00225, BTB, 1 hit
SUPFAMiSSF54695, SSF54695, 1 hit
SSF57667, SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097, BTB, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLOLA5_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9V5M6
Secondary accession number(s): Q058V9
, Q4AB07, Q867J5, Q867M8, Q867P1, Q867T8, Q86BC2, Q8MKX4, Q9V5M5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: February 10, 2021
This is version 153 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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