UniProtKB - Q9V4E1 (Q9V4E1_DROME)
Protein
Submitted name:
Ephrin
Gene
Ephrin
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- ephrin receptor binding Source: FlyBase
GO - Biological processi
- axon guidance Source: FlyBase
- ephrin receptor signaling pathway Source: GO_Central
- melanotic encapsulation of foreign target Source: FlyBase
- mushroom body development Source: FlyBase
- peripheral nervous system development Source: FlyBase
Enzyme and pathway databases
Reactomei | R-DME-2682334, EPH-Ephrin signaling R-DME-3928662, EPHB-mediated forward signaling R-DME-3928663, EPHA-mediated growth cone collapse R-DME-3928664, Ephrin signaling R-DME-3928665, EPH-ephrin mediated repulsion of cells |
Names & Taxonomyi
Protein namesi | Submitted name: EphrinImportedSubmitted name: Ephrin, isoform AImportedSubmitted name: Ephrin, isoform BImportedSubmitted name: Ephrin, isoform CImportedSubmitted name: LD11109pImported |
Gene namesi | ORF Names:CG1862Imported, Dmel_CG1862Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0040324, Ephrin |
Subcellular locationi
Plasma Membrane
- integral component of plasma membrane Source: FlyBase
- plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 188 – 210 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 568 – 586 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 593 – 614 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | FBgn0040324, Expressed in saliva-secreting gland and 37 other tissues |
Interactioni
GO - Molecular functioni
- ephrin receptor binding Source: FlyBase
Protein-protein interaction databases
IntActi | Q9V4E1, 1 interactor |
STRINGi | 7227.FBpp0088146 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 214 – 357 | Ephrin RBDInterPro annotationAdd BLAST | 144 |
Sequence similaritiesi
Belongs to the ephrin family.PROSITE-ProRule annotation
Keywords - Domaini
SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG3858, Eukaryota |
GeneTreei | ENSGT00940000172385 |
HOGENOMi | CLU_024827_0_0_1 |
OMAi | LICMETV |
OrthoDBi | 442109at2759 |
Family and domain databases
Gene3Di | 2.60.40.420, 1 hit |
InterProi | View protein in InterPro IPR008972, Cupredoxin IPR031328, Ephrin IPR001799, Ephrin_RBD |
PANTHERi | PTHR11304, PTHR11304, 1 hit |
Pfami | View protein in Pfam PF00812, Ephrin, 1 hit |
PRINTSi | PR01347, EPHRIN |
SUPFAMi | SSF49503, SSF49503, 1 hit |
PROSITEi | View protein in PROSITE PS51551, EPHRIN_RBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9V4E1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQERSKQLRL TVSWTQSKSQ IHDSCQRRSM LACKRRLTTS KVLEDSHPPV
60 70 80 90 100
AFPNCKSHRH QQQKEKHKVQ LYSGKPLSIK LYVPGSIESI PKIRHKALTT
110 120 130 140 150
TNKQQPAMHR KSKSKSKFQG FNNLKPLYSP SKRQPPEKHS SVLVEAGIES
160 170 180 190 200
KASRHFVGKK RIKNRNCLLS SPQPSPMRCK MMIPFPKFGA TSFVTLLTLI
210 220 230 240 250
CMETVLLSTM SSCAKTFYMH WNTSNSIFRI DNTDHIIDVN KGNLAFEFDQ
260 270 280 290 300
VHIICPVYEP GTFENETEKY IIYNVSKVEY ETCRITNADP RVIAICDKPQ
310 320 330 340 350
KLMFFTITFR PFTPQPGGLE FLPGNDYYFI STSSKDDLYR RIGGRCSTNN
360 370 380 390 400
MKVVFKVCCA PEDNNKTTAL SNSKSVTDTG GAINVNIANN DESHVNSHGN
410 420 430 440 450
NIAIGTNIGI NGGQIIGGPQ SAGIPINPLS GNNNINGIPT TINSNIDQFN
460 470 480 490 500
RIPIQPNIIG NHVGTNAVGT GIVGGGGIIL TPGHAHGNIN MLQPGRGGIN
510 520 530 540 550
GAYPGHHHIQ TGIRINNVPT QHNYPSHKGN ANSNINGNDD HHHYNKHPNE
560 570 580 590 600
VVKNEELTYN SGAATSDGNI FALWIWILSI FPLLSIQSCH LSSYWISASF
610 620 630 640 650
LVSTIAILGI HYLIQITLQT TVQRYSPGMV EITATSMNGM FDQNAGTIEY
DR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF216287 mRNA Translation: AAF28394.1 AE014135 Genomic DNA Translation: AAF59334.2 AE014135 Genomic DNA Translation: AAF59335.2 AE014135 Genomic DNA Translation: AAN06500.1 BT005199 mRNA Translation: AAO61756.1 |
RefSeqi | NP_651927.1, NM_143670.5 NP_726583.1, NM_166770.2 NP_726584.1, NM_166771.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0089075; FBpp0088144; FBgn0040324 FBtr0089076; FBpp0088145; FBgn0040324 FBtr0089077; FBpp0088146; FBgn0040324 |
GeneIDi | 43799 |
KEGGi | dme:Dmel_CG1862 |
UCSCi | CG1862-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF216287 mRNA Translation: AAF28394.1 AE014135 Genomic DNA Translation: AAF59334.2 AE014135 Genomic DNA Translation: AAF59335.2 AE014135 Genomic DNA Translation: AAN06500.1 BT005199 mRNA Translation: AAO61756.1 |
RefSeqi | NP_651927.1, NM_143670.5 NP_726583.1, NM_166770.2 NP_726584.1, NM_166771.2 |
3D structure databases
SMRi | Q9V4E1 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9V4E1, 1 interactor |
STRINGi | 7227.FBpp0088146 |
Protocols and materials databases
DNASUi | 43799 |
Genome annotation databases
EnsemblMetazoai | FBtr0089075; FBpp0088144; FBgn0040324 FBtr0089076; FBpp0088145; FBgn0040324 FBtr0089077; FBpp0088146; FBgn0040324 |
GeneIDi | 43799 |
KEGGi | dme:Dmel_CG1862 |
UCSCi | CG1862-RA, d. melanogaster |
Organism-specific databases
CTDi | 43799 |
FlyBasei | FBgn0040324, Ephrin |
Phylogenomic databases
eggNOGi | KOG3858, Eukaryota |
GeneTreei | ENSGT00940000172385 |
HOGENOMi | CLU_024827_0_0_1 |
OMAi | LICMETV |
OrthoDBi | 442109at2759 |
Enzyme and pathway databases
Reactomei | R-DME-2682334, EPH-Ephrin signaling R-DME-3928662, EPHB-mediated forward signaling R-DME-3928663, EPHA-mediated growth cone collapse R-DME-3928664, Ephrin signaling R-DME-3928665, EPH-ephrin mediated repulsion of cells |
Miscellaneous databases
BioGRID-ORCSi | 43799, 0 hits in 3 CRISPR screens |
GenomeRNAii | 43799 |
Gene expression databases
Bgeei | FBgn0040324, Expressed in saliva-secreting gland and 37 other tissues |
Family and domain databases
Gene3Di | 2.60.40.420, 1 hit |
InterProi | View protein in InterPro IPR008972, Cupredoxin IPR031328, Ephrin IPR001799, Ephrin_RBD |
PANTHERi | PTHR11304, PTHR11304, 1 hit |
Pfami | View protein in Pfam PF00812, Ephrin, 1 hit |
PRINTSi | PR01347, EPHRIN |
SUPFAMi | SSF49503, SSF49503, 1 hit |
PROSITEi | View protein in PROSITE PS51551, EPHRIN_RBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9V4E1_DROME | |
Accessioni | Q9V4E1Primary (citable) accession number: Q9V4E1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | October 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 173 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |