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UniProtKB - Q9V4E1 (Q9V4E1_DROME)

Entry version 167 (26 Feb 2020)
Sequence version 2 (01 Oct 2000)
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Protein
Submitted name:

Ephrin

Gene

Ephrin

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ephrin receptor binding Source: FlyBase
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-2682334 EPH-Ephrin signaling
R-DME-3928662 EPHB-mediated forward signaling
R-DME-3928663 EPHA-mediated growth cone collapse
R-DME-3928664 Ephrin signaling
R-DME-3928665 EPH-ephrin mediated repulsion of cells

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
EphrinImported
Submitted name:
Ephrin, isoform AImported
Submitted name:
Ephrin, isoform BImported
Submitted name:
Ephrin, isoform CImported
Submitted name:
LD11109pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EphrinImported
Synonyms:Dmel\CG1862Imported, ephrinImported, lincRNA.922Imported
ORF Names:CG1862Imported, Dmel_CG1862Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0040324 Ephrin

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei188 – 210HelicalSequence analysisAdd BLAST23
Transmembranei568 – 586HelicalSequence analysisAdd BLAST19
Transmembranei593 – 614HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0040324 Expressed in embryo and 28 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q9V4E1, 1 interactor

STRING: functional protein association networks

More...STRINGi		7227.FBpp0088146

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini214 – 357Ephrin RBDInterPro annotationAdd BLAST144

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ephrin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3858 Eukaryota
ENOG4111FMJ LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000172385

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_024827_0_0_1

KEGG Orthology (KO)

More...KOi		K05463

Identification of Orthologs from Complete Genome Data

More...OMAi		LICMETV

Database of Orthologous Groups

More...OrthoDBi		442109at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.420, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008972 Cupredoxin
IPR031328 Ephrin
IPR001799 Ephrin_RBD

The PANTHER Classification System

More...PANTHERi		PTHR11304 PTHR11304, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00812 Ephrin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01347 EPHRIN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49503 SSF49503, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51551 EPHRIN_RBD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9V4E1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQERSKQLRL TVSWTQSKSQ IHDSCQRRSM LACKRRLTTS KVLEDSHPPV 
        60         70         80         90        100
AFPNCKSHRH QQQKEKHKVQ LYSGKPLSIK LYVPGSIESI PKIRHKALTT 
       110        120        130        140        150
TNKQQPAMHR KSKSKSKFQG FNNLKPLYSP SKRQPPEKHS SVLVEAGIES 
       160        170        180        190        200
KASRHFVGKK RIKNRNCLLS SPQPSPMRCK MMIPFPKFGA TSFVTLLTLI 
       210        220        230        240        250
CMETVLLSTM SSCAKTFYMH WNTSNSIFRI DNTDHIIDVN KGNLAFEFDQ 
       260        270        280        290        300
VHIICPVYEP GTFENETEKY IIYNVSKVEY ETCRITNADP RVIAICDKPQ 
       310        320        330        340        350
KLMFFTITFR PFTPQPGGLE FLPGNDYYFI STSSKDDLYR RIGGRCSTNN 
       360        370        380        390        400
MKVVFKVCCA PEDNNKTTAL SNSKSVTDTG GAINVNIANN DESHVNSHGN 
       410        420        430        440        450
NIAIGTNIGI NGGQIIGGPQ SAGIPINPLS GNNNINGIPT TINSNIDQFN 
       460        470        480        490        500
RIPIQPNIIG NHVGTNAVGT GIVGGGGIIL TPGHAHGNIN MLQPGRGGIN 
       510        520        530        540        550
GAYPGHHHIQ TGIRINNVPT QHNYPSHKGN ANSNINGNDD HHHYNKHPNE 
       560        570        580        590        600
VVKNEELTYN SGAATSDGNI FALWIWILSI FPLLSIQSCH LSSYWISASF 
       610        620        630        640        650
LVSTIAILGI HYLIQITLQT TVQRYSPGMV EITATSMNGM FDQNAGTIEY 

DR
Length:652
Mass (Da):72,302
Last modified:October 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5BA2F02F15964594
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF216287 mRNA Translation: AAF28394.1
AE014135 Genomic DNA Translation: AAF59334.2
AE014135 Genomic DNA Translation: AAF59335.2
AE014135 Genomic DNA Translation: AAN06500.1
BT005199 mRNA Translation: AAO61756.1

NCBI Reference Sequences

More...RefSeqi		NP_651927.1, NM_143670.5
NP_726583.1, NM_166770.2
NP_726584.1, NM_166771.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0089075; FBpp0088144; FBgn0040324
FBtr0089076; FBpp0088145; FBgn0040324
FBtr0089077; FBpp0088146; FBgn0040324

Database of genes from NCBI RefSeq genomes

More...GeneIDi		43799

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG1862

UCSC genome browser

More...UCSCi		CG1862-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216287 mRNA Translation: AAF28394.1
AE014135 Genomic DNA Translation: AAF59334.2
AE014135 Genomic DNA Translation: AAF59335.2
AE014135 Genomic DNA Translation: AAN06500.1
BT005199 mRNA Translation: AAO61756.1
RefSeqiNP_651927.1, NM_143670.5
NP_726583.1, NM_166770.2
NP_726584.1, NM_166771.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9V4E1, 1 interactor
STRINGi7227.FBpp0088146

Genome annotation databases

EnsemblMetazoaiFBtr0089075; FBpp0088144; FBgn0040324
FBtr0089076; FBpp0088145; FBgn0040324
FBtr0089077; FBpp0088146; FBgn0040324
GeneIDi43799
KEGGidme:Dmel_CG1862
UCSCiCG1862-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		43799
FlyBaseiFBgn0040324 Ephrin

Phylogenomic databases

eggNOGiKOG3858 Eukaryota
ENOG4111FMJ LUCA
GeneTreeiENSGT00940000172385
HOGENOMiCLU_024827_0_0_1
KOiK05463
OMAiLICMETV
OrthoDBi442109at2759

Enzyme and pathway databases

ReactomeiR-DME-2682334 EPH-Ephrin signaling
R-DME-3928662 EPHB-mediated forward signaling
R-DME-3928663 EPHA-mediated growth cone collapse
R-DME-3928664 Ephrin signaling
R-DME-3928665 EPH-ephrin mediated repulsion of cells

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		43799

Gene expression databases

BgeeiFBgn0040324 Expressed in embryo and 28 other tissues

Family and domain databases

Gene3Di2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR031328 Ephrin
IPR001799 Ephrin_RBD
PANTHERiPTHR11304 PTHR11304, 1 hit
PfamiView protein in Pfam
PF00812 Ephrin, 1 hit
PRINTSiPR01347 EPHRIN
SUPFAMiSSF49503 SSF49503, 1 hit
PROSITEiView protein in PROSITE
PS51551 EPHRIN_RBD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9V4E1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9V4E1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2000
Last modified: February 26, 2020
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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