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Entry version 175 (29 Sep 2021)
Sequence version 2 (01 Oct 2002)
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Protein

Complex I-49kD

Gene

ND-49

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseImported, TranslocaseUniRule annotationARBA annotation
Biological processTransportUniRule annotationARBA annotation
LigandNADUniRule annotationARBA annotation, UbiquinoneImported

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-611105, Respiratory electron transport
R-DME-6799198, Complex I biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complex I-49kDARBA annotation
Alternative name(s):
NADH-ubiquinone oxidoreductase 49 kDa subunitARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ND-49Imported
Synonyms:CG 1970Imported, CG1970-RAImported, Dmel\CG1970Imported, Ndufs2Imported, NUCMImported
ORF Names:CG1970Imported, Dmel_CG1970Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0039909, ND-49

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0039909

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9V4E0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0039909, Expressed in thoracico-abdominal ganglion (Drosophila) and 47 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9V4E0, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0305832

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9V4E0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini198 – 468Complex1_49kDaInterPro annotationAdd BLAST271

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2870, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009529

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015134_1_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
IMGTSME

Database of Orthologous Groups

More...
OrthoDBi
444312at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9V4E0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.645.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01358, NDH1_NuoD, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001135, NADH_Q_OxRdtase_suD
IPR014029, NADH_UbQ_OxRdtase_49kDa_CS
IPR022885, NDH1_su_D/H
IPR029014, NiFe-Hase_large

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00346, Complex1_49kDa, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56762, SSF56762, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01962, NuoD, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00535, COMPLEX1_49K, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9V4E0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANIMRRTLI PGLSHLRLRP QLVAAGSAAL TSQETRRGAA KWYPDPEFMK
60 70 80 90 100
QFSGPVMYPD EVTSLWTVPP WNSKVTPVEK SVRNLTLNFG PQHPAAHGVL
110 120 130 140 150
RLVLELDGET VMRADPHIGL LHRGTEKLIE YKTYTQALPY FDRLDYVSMM
160 170 180 190 200
CNEQCYSLAV EKLLNIDVPL RAKYIRTLFA EITRILNHIM AVGTHALDVG
210 220 230 240 250
ALTPFFWLFE EREKMMEFYE RVSGARMHAA YIRPGGVSLD MPLGLMDDIY
260 270 280 290 300
EFASKFAERL DEVEDVLTTN RIWVQRTEDI GIVTAEEALN YGFSGVMLRG
310 320 330 340 350
SGIKWDLRKQ QPYDAYNLVN FDVPIGTKGD CYDRYLCRVE EMRQSLRIID
360 370 380 390 400
QCLNQMPAGE IKTDDAKVAP PSRSEMKTSM EALIHHFKLF TQGYQVPPGA
410 420 430 440 450
TYTAIEAPKG EFGVYLISDG SSRPYRCKIK APGFAHLAAL EKIGKQHMLA
460
DVVAIIGTLD VVFGEIDR
Length:468
Mass (Da):52,921
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4943FFF9CBE67DBA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014135 Genomic DNA Translation: AAF59336.2
BT032847 mRNA Translation: ACD81861.1
AE014135 Genomic DNA Translation: AGB96554.1

NCBI Reference Sequences

More...
RefSeqi
NP_001259064.1, NM_001272135.1
NP_651926.1, NM_143669.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0089105; FBpp0088174; FBgn0039909
FBtr0333676; FBpp0305832; FBgn0039909

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
43798

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG1970

UCSC genome browser

More...
UCSCi
CG1970-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014135 Genomic DNA Translation: AAF59336.2
BT032847 mRNA Translation: ACD81861.1
AE014135 Genomic DNA Translation: AGB96554.1
RefSeqiNP_001259064.1, NM_001272135.1
NP_651926.1, NM_143669.2

3D structure databases

SMRiQ9V4E0
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9V4E0, 2 interactors
STRINGi7227.FBpp0305832

Proteomic databases

PRIDEiQ9V4E0

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
43798

Genome annotation databases

EnsemblMetazoaiFBtr0089105; FBpp0088174; FBgn0039909
FBtr0333676; FBpp0305832; FBgn0039909
GeneIDi43798
KEGGidme:Dmel_CG1970
UCSCiCG1970-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
43798
FlyBaseiFBgn0039909, ND-49
VEuPathDBiVectorBase:FBgn0039909

Phylogenomic databases

eggNOGiKOG2870, Eukaryota
GeneTreeiENSGT00390000009529
HOGENOMiCLU_015134_1_1_1
OMAiIMGTSME
OrthoDBi444312at2759
PhylomeDBiQ9V4E0

Enzyme and pathway databases

ReactomeiR-DME-611105, Respiratory electron transport
R-DME-6799198, Complex I biogenesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
43798, 1 hit in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
43798

Gene expression databases

BgeeiFBgn0039909, Expressed in thoracico-abdominal ganglion (Drosophila) and 47 other tissues

Family and domain databases

Gene3Di1.10.645.10, 1 hit
HAMAPiMF_01358, NDH1_NuoD, 1 hit
InterProiView protein in InterPro
IPR001135, NADH_Q_OxRdtase_suD
IPR014029, NADH_UbQ_OxRdtase_49kDa_CS
IPR022885, NDH1_su_D/H
IPR029014, NiFe-Hase_large
PfamiView protein in Pfam
PF00346, Complex1_49kDa, 1 hit
SUPFAMiSSF56762, SSF56762, 1 hit
TIGRFAMsiTIGR01962, NuoD, 1 hit
PROSITEiView protein in PROSITE
PS00535, COMPLEX1_49K, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9V4E0_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9V4E0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: September 29, 2021
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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