Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calcium-transporting ATPase

Gene

PMCA

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calcium-transporting ATPase activity Source: GO_Central

GO - Biological processi

  • cellular calcium ion homeostasis Source: FlyBase
  • regulation of cytosolic calcium ion concentration Source: GO_Central

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processCalcium transportUniRule annotation, Ion transport, Transport
LigandATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-418359 Reduction of cytosolic Ca++ levels
R-DME-5578775 Ion homeostasis
R-DME-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:PMCAImported
Synonyms:BEST:CKImported, BEST:CK01140Imported, BEST:CK02288Imported, BP1021Imported, CG2165Imported, CG34036Imported, CK02288Imported, Dmel\CG42314Imported
ORF Names:CG42314Imported, Dmel_CG42314Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 4

Organism-specific databases

FlyBaseiFBgn0259214 PMCA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei361 – 385HelicalUniRule annotationAdd BLAST25
Transmembranei405 – 429HelicalUniRule annotationAdd BLAST25
Transmembranei848 – 867HelicalUniRule annotationAdd BLAST20
Transmembranei921 – 942HelicalUniRule annotationAdd BLAST22
Transmembranei962 – 981HelicalUniRule annotationAdd BLAST20
Transmembranei1001 – 1021HelicalUniRule annotationAdd BLAST21
Transmembranei1033 – 1051HelicalUniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0259214 Expressed in 32 organ(s), highest expression level in adult Malpighian tubule (Drosophila)

Interactioni

Protein-protein interaction databases

IntActiQ9V4C7, 4 interactors
Q9V4C7, 4 interactors

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 109Cation_ATPase_NInterPro annotationAdd BLAST77

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili271 – 298Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0204 Eukaryota
ENOG410XNNC LUCA
GeneTreeiENSGT00510000046331
OrthoDBiEOG091G057D

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030320 ATP2B1
IPR022141 ATP_Ca_trans_C
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006408 P-type_ATPase_IIB
IPR001757 P_typ_ATPase
PANTHERiPTHR24093:SF245 PTHR24093:SF245, 1 hit
PfamiView protein in Pfam
PF12424 ATP_Ca_trans_C, 1 hit
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01517 ATPase-IIB_Ca, 1 hit
TIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q9V4C7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATIDGRPAQ YGISLKQLRE LMEHRGREGV MKIAENGGIH ELCKKLYTSP
60 70 80 90 100
NEGLSGSKAD EEHRRETFGS NVIPPKPPKT FLTLVWEALQ DVTLIILEVA
110 120 130 140 150
ALVSLGLSFY KPADEDAPVL QEEEEHHGWI EGLAILISVI VVVIVTAFND
160 170 180 190 200
YSKERQFRGL QNRIEGEHKF SVIRGGEVCQ ISVGDILVGD IAQVKYGDLL
210 220 230 240 250
PADGCLIQSN DLKVDESSLT GESDHVKKGP DVDPMVLSGT HVMEGSGKMV
260 270 280 290 300
VTAVGVNSQA GIIFTLLGAA VDEQEAEIKK MKKEAKRANK QKNLTGENDG
310 320 330 340 350
RSQIKGSQAP SQRETVTSEI TKSESEGNHL PQSSSSGAAE TGHKKEKSVL
360 370 380 390 400
QAKLTKLAIQ IGYAGSTIAV LTVIILIIQF CIKTFVIDEK PWKNTYANNL
410 420 430 440 450
VKHLIIGVTV LVVAVPEGLP LAVTLSLAYS VKKMMKDNNL VRHLDACETM
460 470 480 490 500
GNATAICSDK TGTLTTNRMT VVQSYICEKL CKVLPTLSDI PQHVGNLITM
510 520 530 540 550
GISVNSAYTS NIMAGHNPGD LPIQVGNKTE CALLGFVQGL GVKYQSIRDE
560 570 580 590 600
ITEDKFTRVY TFNSVRKSMG TVIPRPNGGY RLYTKGASEI IMKKCAFIYG
610 620 630 640 650
HEGTLEKFTR DMQERLIREV IEPMACDGLR TISVAYRDFV PGKAAINEVH
660 670 680 690 700
IDGEPNWDDE ENIMTNLTCL CVVGIEDPVR PEVPDAIRKC QRAGITVRMV
710 720 730 740 750
TGDNINTARS IASKCGILRP NDDFLILEGK EFNRRIRDSN GDIQQHLIDK
760 770 780 790 800
VWPKLRVLAR SSPTDKYTLV KGIIDSTVSE NREVVAVTGD GTNDGPALKK
810 820 830 840 850
ADVGFAMGIA GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSIAKFLQ
860 870 880 890 900
FQLTVNVVAV IVAFIGACAV QDSPLKAVQM LWVNLIMDTL ASLALATEFP
910 920 930 940 950
TPDLLLRKPY GRTKPLISRT MMKNILGQAL YQLIIIFGLL FVGDVILDIE
960 970 980 990 1000
SGRGQELNAG PTQHFTIIFN TFVMMTLFNE INARKIHGQR NVIEGLLTNP
1010 1020 1030 1040 1050
IFYTIWIFTM ISQVLIIQYG KMAFSTKALT LDQWLWCIFF GIGTLVWGQL
1060 1070 1080 1090 1100
ITSVPTRKLP KILSWGRGHP EEYTDGMNLG EERFDSIDSD KKPRAGQILW
1110 1120 1130 1140 1150
IRGLTRLQTQ VIGGELQERL IPVPYSKSNT DQAIRVVNAF RQGLDARYGD
1160 1170 1180 1190 1200
HTNTSLAEVL RKQTSLSKRL SETSSIEYAD NIPDELTIPE IDVERLSSHS

HTETAV
Length:1,206
Mass (Da):132,943
Last modified:February 9, 2010 - v5
Checksum:i76ED7F59F421205D
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q59DP8Q59DP8_DROME
Calcium-transporting ATPase
PMCA BEST:CK, BEST:CK01140, BEST:CK02288, BP1021, CG2165
1,120Annotation score:
Q59DQ0Q59DQ0_DROME
Calcium-transporting ATPase
PMCA BEST:CK, BEST:CK01140, BEST:CK02288, BP1021, CG2165
1,183Annotation score:
E6EK17E6EK17_DROME
Calcium-transporting ATPase
PMCA BEST:CK, BEST:CK01140, BEST:CK02288, BP1021, CG2165
1,187Annotation score:
E6EK18E6EK18_DROME
Calcium-transporting ATPase
PMCA BEST:CK, BEST:CK01140, BEST:CK02288, BP1021, CG2165
1,210Annotation score:
Q59DP9Q59DP9_DROME
Calcium-transporting ATPase
PMCA BEST:CK, BEST:CK01140, BEST:CK02288, BP1021, CG2165
1,255Annotation score:
E6EK15E6EK15_DROME
Calcium-transporting ATPase
PMCA BEST:CK, BEST:CK01140, BEST:CK02288, BP1021, CG2165
1,194Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014135 Genomic DNA Translation: AAF59350.5
AE014135 Genomic DNA Translation: AAN06528.5
AE014135 Genomic DNA Translation: ADV37598.1
RefSeqiNP_001188514.1, NM_001201585.2
NP_726564.5, NM_166754.6
NP_726565.5, NM_166755.6
UniGeneiDm.3785

Genome annotation databases

EnsemblMetazoaiFBtr0300554; FBpp0289781; FBgn0259214
FBtr0300557; FBpp0289784; FBgn0259214
FBtr0304046; FBpp0293009; FBgn0259214
GeneIDi43787
UCSCiCG42314-RC d. melanogaster

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014135 Genomic DNA Translation: AAF59350.5
AE014135 Genomic DNA Translation: AAN06528.5
AE014135 Genomic DNA Translation: ADV37598.1
RefSeqiNP_001188514.1, NM_001201585.2
NP_726564.5, NM_166754.6
NP_726565.5, NM_166755.6
UniGeneiDm.3785

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9V4C7, 4 interactors
Q9V4C7, 4 interactors

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0300554; FBpp0289781; FBgn0259214
FBtr0300557; FBpp0289784; FBgn0259214
FBtr0304046; FBpp0293009; FBgn0259214
GeneIDi43787
UCSCiCG42314-RC d. melanogaster

Organism-specific databases

CTDi43787
FlyBaseiFBgn0259214 PMCA

Phylogenomic databases

eggNOGiKOG0204 Eukaryota
ENOG410XNNC LUCA
GeneTreeiENSGT00510000046331
OrthoDBiEOG091G057D

Enzyme and pathway databases

ReactomeiR-DME-418359 Reduction of cytosolic Ca++ levels
R-DME-5578775 Ion homeostasis
R-DME-936837 Ion transport by P-type ATPases

Miscellaneous databases

ChiTaRSiPMCA fly
GenomeRNAii43787

Gene expression databases

BgeeiFBgn0259214 Expressed in 32 organ(s), highest expression level in adult Malpighian tubule (Drosophila)

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030320 ATP2B1
IPR022141 ATP_Ca_trans_C
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006408 P-type_ATPase_IIB
IPR001757 P_typ_ATPase
PANTHERiPTHR24093:SF245 PTHR24093:SF245, 1 hit
PfamiView protein in Pfam
PF12424 ATP_Ca_trans_C, 1 hit
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01517 ATPase-IIB_Ca, 1 hit
TIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ9V4C7_DROME
AccessioniPrimary (citable) accession number: Q9V4C7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: February 9, 2010
Last modified: November 7, 2018
This is version 170 of the entry and version 5 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again