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Entry version 147 (03 Jul 2019)
Sequence version 2 (01 Oct 2002)
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Protein

Plexin-B

Gene

PlexB

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in peripheral and central nervous system axon guidance. Acts as a receptor for Sema-2a and seems to transduce signal by suppressing Rac activity and enhancing Rho activity.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-416482 G alpha (12/13) signalling events
R-DME-416572 Sema4D induced cell migration and growth-cone collapse
R-DME-416700 Other semaphorin interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plexin-B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PlexBImported
ORF Names:CG17245Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0025740 PlexB

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini34 – 1380ExtracellularSequence analysisAdd BLAST1347
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1381 – 1401HelicalSequence analysisAdd BLAST21
Topological domaini1402 – 2051CytoplasmicSequence analysisAdd BLAST650

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024855434 – 2051Plexin-BAdd BLAST2018

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi131 ↔ 136PROSITE-ProRule annotation
Disulfide bondi165 ↔ 173PROSITE-ProRule annotation
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi276N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi322 ↔ 380PROSITE-ProRule annotation
Glycosylationi400N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi455N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi536 ↔ 553PROSITE-ProRule annotation
Glycosylationi541N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi542 ↔ 586PROSITE-ProRule annotation
Disulfide bondi545 ↔ 562PROSITE-ProRule annotation
Disulfide bondi556 ↔ 568PROSITE-ProRule annotation
Disulfide bondi622 ↔ 641PROSITE-ProRule annotation
Glycosylationi863N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1053N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1092N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1140N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1181N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1316N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9V4A7

PRoteomics IDEntifications database

More...
PRIDEi
Q9V4A7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed in the embryonic nervous system.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0025740 Expressed in 8 organ(s), highest expression level in head

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9V4A7 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9V4A7 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PlexA.

Interacts with Rho1 and with the active forms of Rac1 and Rac2.

Interacts with Sema-2a.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
68604, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q9V4A7, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0300616

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9V4A7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini61 – 533SemaPROSITE-ProRule annotationAdd BLAST473
Domaini535 – 587PSI 1Add BLAST53
Domaini683 – 730PSI 2Add BLAST48
Domaini834 – 880PSI 3Add BLAST47
Domaini888 – 975IPT/TIG 1Add BLAST88
Domaini977 – 1064IPT/TIG 2Add BLAST88
Domaini1097 – 1193IPT/TIG 3Add BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1402 – 1784Interaction with PlexAAdd BLAST383
Regioni1722 – 1728Interaction with activated Rac1 and Rac27
Regioni1788 – 1827Interaction with Rho1Add BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1402 – 1451Sequence analysisAdd BLAST50

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3610 Eukaryota
ENOG410XR88 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182830

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9V4A7

KEGG Orthology (KO)

More...
KOi
K06821

Identification of Orthologs from Complete Genome Data

More...
OMAi
IMQIKPL

Database of Orthologous Groups

More...
OrthoDBi
90434at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9V4A7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
2.60.40.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR031146 Invert_Plexin-B
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR041019 TIG1_plexin
IPR041362 TIG2_plexin
IPR015943 WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22625 PTHR22625, 1 hit
PTHR22625:SF58 PTHR22625:SF58, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits
PF18020 TIG_2, 1 hit
PF17960 TIG_plexin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51004 SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9V4A7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRKELYCAN IIHVLHVLCI IIILGSQHYC VNCIEELPAQ ALSPLNDIVA
60 70 80 90 100
QFNLPSIPVQ STASSYGNRS IGNNIESVRD SQSKNYFTHM SFDFMHNVLF
110 120 130 140 150
AGATNKILKL NENLRVLAEA VTGPLHDSPQ CHAGGCPEDI ETSLVNNFNK
160 170 180 190 200
ILVVSYAHDG ILIACGSIRQ GACEIYSLPR FPATPQFFAV PLAANDENAS
210 220 230 240 250
TYAFVGPARY AWKEEDILYV GTTFTNVGDY RHDVPAISSR RLDDLNYAEF
260 270 280 290 300
SIQQSIINID VKYRDHFLVD YIYGFNSSEY AYFIIVQKKS HLADEAGYVT
310 320 330 340 350
RLARICITDP NYDSYTEITV QCTATENNVD YNIVRDAKVT PASHKLAQKM
360 370 380 390 400
GIKKDDHVLV TVFSPSREIS NQPESKSAMC IYSIKDIEDM FIENIHLCFN
410 420 430 440 450
GTTKDRNLGY ISGTINDGRC PIVGSLGNIY NFCSVGLKIS GVSPITAHAL
460 470 480 490 500
FHFDNVSVTS VTATSTTDQQ HSLAFLGTNM GVIKKVLLSG QSPGEYEEIV
510 520 530 540 550
VDAGNRILPN TMMSPKKDFL YVLSQRKITK LRIEHCSVYT NCSACLESRD
560 570 580 590 600
PFCGWCSLEK RCTVRSTCQR DTSASRWLSL GSGQQCIEFE SIIPEKIPIS
610 620 630 640 650
ELSHLHLIIR TLPEPFNAKY RCVFGNSTPI DAEILENGLG CATPPLDERP
660 670 680 690 700
LIPTNTDHIL VPLSVRSSET NKDFVSRNFA FFDCSHHGNC QECLQSSWGC
710 720 730 740 750
NWCIFDNKCV HKSLQCRNIE NAVSTVGHCP HLKKNRPEIL LPVRVPIEIR
760 770 780 790 800
LEIENLPKPK SAHAGFLCTI HIEAAQMLLP AHVESNKIVV CEKTPYFYEI
810 820 830 840 850
NTHEYQAKVV VTWNFQHYVD TAIVTLYKCD VLGSHREHPD CSLCVTRDPK
860 870 880 890 900
YKCAWCSNSC VYNETCIADK NSISSGSKSA IENECPLPRI DIIKPLSGPV
910 920 930 940 950
EGGTLITIEG SNLGIREEDV RGKIFIGSVP CELENYQISV KIECRTGASL
960 970 980 990 1000
YEMSAPIKVA NDAGFTESSV QFHFKNVLLT GLYPTIGPRS GGTQLSLIGK
1010 1020 1030 1040 1050
FLNIGSTMRA FLDEYECHID VTQASSSQVS CTTSEATQPE PIRSLHLVID
1060 1070 1080 1090 1100
GANRTLECQI STPSITNTNP TRSNFGSYQL RSLPRQPCSI FNYTQDPRIM
1110 1120 1130 1140 1150
QIKPLRSFKS GGRVLTVHGI YLNSIQKPEL EVFYDNERVN KTSCVVINSN
1160 1170 1180 1190 1200
QMECPSPPVN YKFETFKKTN RKMDTELHLQ NSSFQTETRY KNEYDRKKRR
1210 1220 1230 1240 1250
ADFGDTFRLY TNAGSSANYF VNNNMDVTTF VKVHETQLNL QLSFVMDNVQ
1260 1270 1280 1290 1300
LVRNLNKYFH DIRSTIVYLA DPKYLPFPND GVKLYKGDSL VIEGELLNLA
1310 1320 1330 1340 1350
ADEYDVNVTI GTSQCNITSL ALNQLLCIPP EQQPLPTDEN GVDQSTDLPL
1360 1370 1380 1390 1400
VVVKVGRNLR FVIGYLKYDL NKPYVFSHAL LVGILTVALL VVVFVIVLII
1410 1420 1430 1440 1450
FRRKSTQAER EYKRIQIQMI TLESNVRSEC KQAFAELQTD MTDLTADLES
1460 1470 1480 1490 1500
TGIPTLDHVN YIMKVFFPGV SDHPILNSPK FREGSPQTNY DAAMVQFEQL
1510 1520 1530 1540 1550
IGNKYFLLMF IETLEAQRSS FSIRDRVNVA SLIMVVLMNK MEYATEILKS
1560 1570 1580 1590 1600
LLLRLIDKSL ASKHPQLMLR RTESVVEKML TNYLAICMYD YLKEYAGSNL
1610 1620 1630 1640 1650
FLLFKAIKHQ IEKGLVDAIT NDARYSLSEE RLLHEQVTHS VVILHILQDD
1660 1670 1680 1690 1700
LDEKVQCRVN DWDTISQVKL KILDAIFKNT PFSMRPSVNE VDLEWRHGRG
1710 1720 1730 1740 1750
GHLTLQDEDL TTKTVNGWKR LNTLAHYGVK ESAVMSLIAR QNDNYHIPYS
1760 1770 1780 1790 1800
KNQNSAPYHN FYFINNSQSH IIINNDIESG LQQPRVYHLV KPNIPDHYMN
1810 1820 1830 1840 1850
IKNSVLSGGS PAFQSHVVNN CNDRVNKTIP EVYLTRLLAT KGTIQKFVDD
1860 1870 1880 1890 1900
FFSIILTVNE ELPPAVKWLF DLLDEAARRH DIADTDIVHA WKSNCLPLRF
1910 1920 1930 1940 1950
WVNFIKNPDF IFDVNKTYSV DSCLSVIAQT FMDACSTSEH RLGKDSPSNK
1960 1970 1980 1990 2000
LLFAKDIPNY RIMVKEFYRD VSRLPQISDQ EMSTAMQQLS VRQNEEFDTI
2010 2020 2030 2040 2050
SALKELYIYI TKYKDQIMES LETDINCRKM HLSRKLGNVA ATLDGDCTSN

C
Length:2,051
Mass (Da):231,680
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB65A57D7A255B44D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9XVL5H9XVL5_DROME
Plexin B, isoform B
PlexB CG17245, Dmel\CG17245, plex, Plex B, plex B
2,051Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1082S → A in AAD09426 (PubMed:9875845).Curated1
Sequence conflicti1289S → T in AAD09426 (PubMed:9875845).Curated1
Sequence conflicti1526R → Q in AAD09426 (PubMed:9875845).Curated1
Sequence conflicti1685R → K in AAD09426 (PubMed:9875845).Curated1
Sequence conflicti1691V → L in AAD09426 (PubMed:9875845).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF106933 mRNA Translation: AAD09426.1
AE014135 Genomic DNA Translation: AAF59374.2
BT010009 mRNA Translation: AAQ22478.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T13164

NCBI Reference Sequences

More...
RefSeqi
NP_001245400.1, NM_001258471.2
NP_524616.2, NM_079877.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0089179; FBpp0088246; FBgn0025740
FBtr0308297; FBpp0300616; FBgn0025740

Database of genes from NCBI RefSeq genomes

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GeneIDi
43766

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG17245

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106933 mRNA Translation: AAD09426.1
AE014135 Genomic DNA Translation: AAF59374.2
BT010009 mRNA Translation: AAQ22478.1
PIRiT13164
RefSeqiNP_001245400.1, NM_001258471.2
NP_524616.2, NM_079877.4

3D structure databases

SMRiQ9V4A7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi68604, 12 interactors
IntActiQ9V4A7, 2 interactors
STRINGi7227.FBpp0300616

Proteomic databases

PaxDbiQ9V4A7
PRIDEiQ9V4A7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0089179; FBpp0088246; FBgn0025740
FBtr0308297; FBpp0300616; FBgn0025740
GeneIDi43766
KEGGidme:Dmel_CG17245

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
43766
FlyBaseiFBgn0025740 PlexB

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410XR88 LUCA
GeneTreeiENSGT00950000182830
InParanoidiQ9V4A7
KOiK06821
OMAiIMQIKPL
OrthoDBi90434at2759
PhylomeDBiQ9V4A7

Enzyme and pathway databases

ReactomeiR-DME-416482 G alpha (12/13) signalling events
R-DME-416572 Sema4D induced cell migration and growth-cone collapse
R-DME-416700 Other semaphorin interactions

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
43766

Protein Ontology

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PROi
PR:Q9V4A7

Gene expression databases

BgeeiFBgn0025740 Expressed in 8 organ(s), highest expression level in head
ExpressionAtlasiQ9V4A7 differential
GenevisibleiQ9V4A7 DM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR031146 Invert_Plexin-B
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR041019 TIG1_plexin
IPR041362 TIG2_plexin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PTHR22625:SF58 PTHR22625:SF58, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits
PF18020 TIG_2, 1 hit
PF17960 TIG_plexin, 1 hit
SMARTiView protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 3 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLXB_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9V4A7
Secondary accession number(s): O96682
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 1, 2002
Last modified: July 3, 2019
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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