Importin subunit alpha

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• myosin binding Source: FlyBase <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Sisyphus, the Drosophila myosin XV homolog, traffics within filopodia transporting key sensory and adhesion cargos."
    Liu R., Woolner S., Johndrow J.E., Metzger D., Flores A., Parkhurst S.M.
    Development 135:53-63(2008) [PubMed] [Europe PMC] [Abstract]
• Notch binding Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The Drosophila importin-alpha3 is required for nuclear import of notch in vivo and it displays synergistic effects with notch receptor on cell proliferation."
    Sachan N., Mishra A.K., Mutsuddi M., Mukherjee A.
    PLoS One 8:e68247-e68247(2013) [PubMed] [Europe PMC] [Abstract]
• nuclear import signal receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• nuclear localization sequence binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• anatomical structure morphogenesis Source: UniProt
• NLS-bearing protein import into nucleus Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein import into nucleus Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The Drosophila importin-alpha3 is required for nuclear import of notch in vivo and it displays synergistic effects with notch receptor on cell proliferation."
    Sachan N., Mishra A.K., Mutsuddi M., Mukherjee A.
    PLoS One 8:e68247-e68247(2013) [PubMed] [Europe PMC] [Abstract]
• response to UV Source: FlyBaseInferred from direct assayⁱ
  • "Tiling of r7 axons in the Drosophila visual system is mediated both by transduction of an activin signal to the nucleus and by mutual repulsion."
    Ting C.Y., Herman T., Yonekura S., Gao S., Wang J., Serpe M., O'Connor M.B., Zipursky S.L., Lee C.H.
    Neuron 56:793-806(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• myosin binding Source: FlyBaseInferred from physical interactionⁱ
  • "Sisyphus, the Drosophila myosin XV homolog, traffics within filopodia transporting key sensory and adhesion cargos."
    Liu R., Woolner S., Johndrow J.E., Metzger D., Flores A., Parkhurst S.M.
    Development 135:53-63(2008) [PubMed] [Europe PMC] [Abstract]
• Notch binding Source: FlyBaseInferred from direct assayⁱ
  • "The Drosophila importin-alpha3 is required for nuclear import of notch in vivo and it displays synergistic effects with notch receptor on cell proliferation."
    Sachan N., Mishra A.K., Mutsuddi M., Mukherjee A.
    PLoS One 8:e68247-e68247(2013) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MTSMEQNRLQ NFKNKGKDQD EMRRRRNEVT VELRKNKREE TILKRRNVPN 
        60         70         80         90        100
LDSNTDEEEQ LSSSIDLKKL AKAAADATKP EQQLAAVQAA RKLLSSDKNP 
       110        120        130        140        150
PINDLIQSDI LPILVECLKQ HNHTMLQFEA AWALTNIASG TSAQTNEVVA 
       160        170        180        190        200
AGAVPLFLQL LNSPAPNVCE QAVWALGNII GDGPLLRDFV IKHGVVQPLL 
       210        220        230        240        250
SFIKPDIPIT FLRNVTWVIV NLCRNKDPAP PTATIHEILP ALNVLIHHTD 
       260        270        280        290        300
TNILVDTVWA ISYLTDGGND QIQMVIESGV VPKLIPLLGN SEVKVQTAAL 
       310        320        330        340        350
RAVGNIVTGS DEQTQVVLNY DALSYFPGLL SHPKEKIRKE AVWFLSNITA 
       360        370        380        390        400
GNQSQVQAVI NVGLLPKIIE NLSKGEFQTQ KEAAWAISNL TISGNREQVF 
       410        420        430        440        450
TLIKEGVIPP FCDLLSCQDT QVINVVLDGL NNMLKVADSH VEAVANCIEE 
       460        470        480        490        500
CEGLAKIERL QSHENVEIYK LAYEIIDQYF TDEGEQTNMA PTSDGAQYNF 
       510 
DPHADRLTMN SFNF                                        

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ