UniProtKB - Q9V447 (KRH2_DROME)
Protein
Krueppel homolog 2
Gene
Kr-h2
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Member of the dosage-dependent hierarchy effective upon white gene expression.1 Publication
GO - Biological processi
- endoplasmic reticulum tubular network organization Source: GO_Central
- membrane organization Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Krueppel homolog 2Alternative name(s): Protein Kr-h2 |
Gene namesi | Name:Kr-h2 ORF Names:CG9159 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0266449, Kr-h2 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
Other locations
- endomembrane system Source: FlyBase
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 53 – 73 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 125 – 145 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 181 – 201 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220903 | 1 – 276 | Krueppel homolog 2Add BLAST | 276 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 22 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9V447 |
PRIDEi | Q9V447 |
PTM databases
iPTMneti | Q9V447 |
Expressioni
Gene expression databases
Bgeei | FBgn0266449, Expressed in Malpighian tubule and 37 other tissues |
ExpressionAtlasi | Q9V447, baseline and differential |
Genevisiblei | Q9V447, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 60023, 64 interactors |
DIPi | DIP-20347N |
IntActi | Q9V447, 4 interactors |
STRINGi | 7227.FBpp0078823 |
Family & Domainsi
Sequence similaritiesi
Belongs to the PER33/POM33 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4002, Eukaryota |
HOGENOMi | CLU_071391_0_0_1 |
InParanoidi | Q9V447 |
OMAi | ALHACTF |
OrthoDBi | 1360050at2759 |
PhylomeDBi | Q9V447 |
Family and domain databases
InterProi | View protein in InterPro IPR005344, TMEM33/Pom33 |
Pfami | View protein in Pfam PF03661, TMEM33_Pom33, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9V447-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAPTDQPPR SEGAQTNSSE RSSQQQEQPQ QSQSQNVPAK LLQHFQTNRI
60 70 80 90 100
DSALWALRLL VIFFTVSYVL PIFTSQQSAF SKVMLANAAI SALRLHQRLP
110 120 130 140 150
AFAFSREFLA RLFAEDSCHY MMYSLIFFNI RPSLLVLIPV LLYSVLHASS
160 170 180 190 200
YSLKLLDLIG QNSWWGARFI ISIVEFQAAN ILKATAFCEI FIMPYAIVLA
210 220 230 240 250
FMNHAGLMTP VIYYHYLVMR YSSRRNPYPR NAFAELRITF EALAARSPPA
260 270
FAKIIRGGIG FVNRLAPQLQ PAAAQE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketX2J4W8 | X2J4W8_DROME | Kruppel homolog 2, isoform C | Kr-h2 anon-26Ba, Dmel\CG9159, Kr-h, Kr-H2, CG9159 | 276 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF148686 Genomic DNA Translation: AAD45272.1 AE014134 Genomic DNA Translation: AAF52341.1 AE014134 Genomic DNA Translation: ACZ94185.1 AY118281 mRNA Translation: AAM48310.1 BT072913 mRNA Translation: ACN81334.1 |
RefSeqi | NP_001162894.1, NM_001169423.1 NP_001285663.1, NM_001298734.1 NP_523490.1, NM_078766.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0079192; FBpp0078823; FBgn0266449 FBtr0302212; FBpp0291422; FBgn0266449 FBtr0343126; FBpp0309826; FBgn0266449 |
GeneIDi | 33859 |
KEGGi | dme:Dmel_CG9159 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF148686 Genomic DNA Translation: AAD45272.1 AE014134 Genomic DNA Translation: AAF52341.1 AE014134 Genomic DNA Translation: ACZ94185.1 AY118281 mRNA Translation: AAM48310.1 BT072913 mRNA Translation: ACN81334.1 |
RefSeqi | NP_001162894.1, NM_001169423.1 NP_001285663.1, NM_001298734.1 NP_523490.1, NM_078766.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 60023, 64 interactors |
DIPi | DIP-20347N |
IntActi | Q9V447, 4 interactors |
STRINGi | 7227.FBpp0078823 |
PTM databases
iPTMneti | Q9V447 |
Proteomic databases
PaxDbi | Q9V447 |
PRIDEi | Q9V447 |
Genome annotation databases
EnsemblMetazoai | FBtr0079192; FBpp0078823; FBgn0266449 FBtr0302212; FBpp0291422; FBgn0266449 FBtr0343126; FBpp0309826; FBgn0266449 |
GeneIDi | 33859 |
KEGGi | dme:Dmel_CG9159 |
Organism-specific databases
CTDi | 33859 |
FlyBasei | FBgn0266449, Kr-h2 |
Phylogenomic databases
eggNOGi | KOG4002, Eukaryota |
HOGENOMi | CLU_071391_0_0_1 |
InParanoidi | Q9V447 |
OMAi | ALHACTF |
OrthoDBi | 1360050at2759 |
PhylomeDBi | Q9V447 |
Miscellaneous databases
BioGRID-ORCSi | 33859, 0 hits in 1 CRISPR screen |
GenomeRNAii | 33859 |
PROi | PR:Q9V447 |
Gene expression databases
Bgeei | FBgn0266449, Expressed in Malpighian tubule and 37 other tissues |
ExpressionAtlasi | Q9V447, baseline and differential |
Genevisiblei | Q9V447, DM |
Family and domain databases
InterProi | View protein in InterPro IPR005344, TMEM33/Pom33 |
Pfami | View protein in Pfam PF03661, TMEM33_Pom33, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KRH2_DROME | |
Accessioni | Q9V447Primary (citable) accession number: Q9V447 Secondary accession number(s): C0PV57, E1JHA1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families