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Protein

Thioredoxin-2

Gene

Trx-2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei26Deprotonates C-terminal active site CysBy similarity1
Active sitei32NucleophileBy similarity1
Sitei33Contributes to redox potential valueBy similarity1
Sitei34Contributes to redox potential valueBy similarity1
Active sitei35NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: UniProtKB
  • cellular response to oxidative stress Source: GO_Central
  • defense response to fungus Source: FlyBase
  • determination of adult lifespan Source: FlyBase
  • glycerol ether metabolic process Source: InterPro
  • response to oxidative stress Source: FlyBase

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-2
Short name:
DmTrx-2
Gene namesi
Name:Trx-2
ORF Names:CG31884
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0040070 Trx-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001200341 – 106Thioredoxin-2Add BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 35Redox-activePROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9V429
PeptideAtlasiQ9V429
PRIDEiQ9V429

Expressioni

Developmental stagei

Larval stages.1 Publication

Gene expression databases

BgeeiFBgn0040070
ExpressionAtlasiQ9V429 baseline and differential
GenevisibleiQ9V429 DM

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi60380, 56 interactors
IntActiQ9V429, 5 interactors
STRINGi7227.FBpp0079436

Structurei

Secondary structure

1106
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 4Combined sources3
Helixi8 – 18Combined sources11
Beta strandi21 – 28Combined sources8
Helixi33 – 48Combined sources16
Turni49 – 52Combined sources4
Beta strandi53 – 59Combined sources7
Turni60 – 62Combined sources3
Helixi64 – 69Combined sources6
Beta strandi74 – 82Combined sources9
Beta strandi85 – 92Combined sources8
Helixi95 – 104Combined sources10

3D structure databases

ProteinModelPortaliQ9V429
SMRiQ9V429
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9V429

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 106ThioredoxinPROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Belongs to the thioredoxin family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0907 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00530000063008
InParanoidiQ9V429
KOiK03671
OMAiSKYAFQE
OrthoDBiEOG091G01FG
PhylomeDBiQ9V429

Family and domain databases

InterProiView protein in InterPro
IPR005746 Thioredoxin
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PANTHERiPTHR10438 PTHR10438, 1 hit
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
PIRSFiPIRSF000077 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR01068 thioredoxin, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9V429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYQVKDKAD LDGQLTKASG KLVVLDFFAT WCGPCKMISP KLVELSTQFA
60 70 80 90 100
DNVVVLKVDV DECEDIAMEY NISSMPTFVF LKNGVKVEEF AGANAKRLED

VIKANI
Length:106
Mass (Da):11,737
Last modified:February 28, 2018 - v3
Checksum:i255341DD95839FB8
GO

Sequence cautioni

The sequence AAL25497 differs from that shown. Intron retention.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220362 mRNA Translation: AAF37263.1
AE014134 Genomic DNA Translation: AAN10700.1
AE014134 Genomic DNA Translation: AAN10701.1
AY060458 mRNA Translation: AAL25497.1 Sequence problems.
BT120324 mRNA Translation: ADC54215.1
RefSeqiNP_523526.1, NM_078802.4
NP_723475.1, NM_164863.3
UniGeneiDm.2664

Genome annotation databases

EnsemblMetazoaiFBtr0079839; FBpp0079436; FBgn0040070
FBtr0079840; FBpp0079437; FBgn0040070
GeneIDi34281
KEGGidme:Dmel_CG31884
UCSCiCG31884-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiTHIO2_DROME
AccessioniPrimary (citable) accession number: Q9V429
Secondary accession number(s): A4V0H9, D3DMZ9, Q95SW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: February 28, 2018
Last modified: July 18, 2018
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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