Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 149 (16 Oct 2019)
Sequence version 1 (01 May 2000)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

LD36341p

Gene

Smg5

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LD36341pImported
Submitted name:
SMG5 proteinImported
Submitted name:
Smg5, isoform AImported
Submitted name:
Smg5, isoform BImported
Submitted name:
Smg5, isoform CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Smg5Imported
Synonyms:anon-34EaImported, BG:DS08220.2Imported, Dmel\CG8954Imported, dSMG5Imported, SMG5Imported, smg5Imported
ORF Names:CG8954Imported, Dmel_CG8954Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0019890 Smg5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9V414

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0019890 Expressed in 48 organ(s), highest expression level in brain

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9V414, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0080138

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9V414

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1012 – 1139PINcInterPro annotationAdd BLAST128

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni466 – 589DisorderedSequence analysisAdd BLAST124
Regioni855 – 915DisorderedSequence analysisAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1049 – 1069Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi466 – 496PolyampholyteSequence analysisAdd BLAST31
Compositional biasi502 – 522PolyampholyteSequence analysisAdd BLAST21
Compositional biasi547 – 568AcidicSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INQY Eukaryota
ENOG410XPF4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154566

KEGG Orthology (KO)

More...
KOi
K11125

Identification of Orthologs from Complete Genome Data

More...
OMAi
VRTKKCI

Database of Orthologous Groups

More...
OrthoDBi
184090at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018834 DNA/RNA-bd_Est1-type
IPR019458 EST1
IPR002716 PIN_dom
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10374 EST1, 1 hit
PF10373 EST1_DNA_bind, 1 hit
PF13638 PIN_4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00670 PINc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9V414-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVTFSSGGS SNASSECAID GGTNRCRGLE PNNGTCILSQ EVKDLYRSLY
60 70 80 90 100
TASKQLDDAK RNVQSVGQLF QHEIEEKRSL LVQLCKQIIF KDYQSVGKKV
110 120 130 140 150
REVMWRRGYY EFIAFVKKNW HKQCQDAATA QENMQKLERF LCAGIFNYKR
160 170 180 190 200
LSARMEEIYD LDLKYLIDFS IISDGYISDM IGDTMESSHS GTHAVDKSLE
210 220 230 240 250
AVSFALDTIH SSLLSLGDLH RYFLDFRIDS KLSISKEQVA KYYLEAFKLN
260 270 280 290 300
PAIGMAQNQL GTLHYGQNHD LDSTYHYLYS LVCIIPFELS ENNLNKLFAK
310 320 330 340 350
HTEYLERMDP EKLDFNIEDF FARFYLIVDI FFFDKEVPDF NALCHCVLID
360 370 380 390 400
LRKILCSQQL RVPEPSIFKI VSILFFCLSK LKMINSPKVY SLHAFLVAAC
410 420 430 440 450
SDLMDACIVS IEQTILARAQ DNERFQAEYE ERFQEFDTVV RKSRNEYKNW
460 470 480 490 500
LAAVGECERK DKKLMPRPHS LKDCSSDSRD SQHSGEEAKT QEAADGDKIG
510 520 530 540 550
EAVSTRSSDE AKESDLKTPL SCKSKRRGMR LRRRRRKIAQ SDDSSCYDSE
560 570 580 590 600
SELDTDFYSD EEDYTDLSSN FDTDFSDIDA ADPGEPCGEE RYAAANYSKK
610 620 630 640 650
ERKAGGGGGG GVGGVVYSDN EDVVIEEEKI VYPNEVERRS NSQEADSEEL
660 670 680 690 700
LRSFEVLQLN FKSAEDAQSK PVAPPPVSFS EPPKKLVYRN KYTKINPNIV
710 720 730 740 750
IDCLHNEPTI RALKMLFDWL RINPEILIGC YHSNPEFVHK IMKLLNYCNI
760 770 780 790 800
DIFTRKVYFE RDLLTTANVR DSLVELFDVR ANVPLTEDFA FKNFDIFQST
810 820 830 840 850
QITLDWETII RERVTPQEES ILRIFKMVDF GFFICKQKKF NYRFCVKTRR
860 870 880 890 900
FTETQKKKQR EEKKGGGSRR RERRTAPKTN RTKRNEGRTR RYSDRKNGIV
910 920 930 940 950
RKSYTSNEEK DTVEECRKMP RKGYLRNRNA EKAAAVITSA TGTSVAGGTS
960 970 980 990 1000
ASTTTNSVIE KLNLQSSSGA DEERSEAKSK KCELMGKLWL QNEVETLEEE
1010 1020 1030 1040 1050
LRDSPAHVVM SPFVVVDSKA LTEYNGIVKS LVRTKKCIVL IPNAVLNELD
1060 1070 1080 1090 1100
DLKKRSENVR HVIRWLEQEF KQGNRHLRAQ RDNESQPLSL LKISRKMDRD
1110 1120 1130 1140 1150
ASVFLQIAQF CNHLVANHAD PHVSELQKSV VTYLSGDNLH EKNRQQQNFS
1160 1170
YTGILDSIPV RYAQIQSFYA KFKANKK
Length:1,177
Mass (Da):135,314
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B532D229E690841
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53351.1
AE014134 Genomic DNA Translation: AAF53352.1
BT031137 mRNA Translation: ABX00759.1
AE014134 Genomic DNA Translation: AHN54428.1
AJ556817 mRNA Translation: CAD89222.1

NCBI Reference Sequences

More...
RefSeqi
NP_001285914.1, NM_001298985.1
NP_609685.1, NM_135841.5
NP_723851.1, NM_165069.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0080561; FBpp0080138; FBgn0019890
FBtr0080562; FBpp0080139; FBgn0019890
FBtr0343669; FBpp0310261; FBgn0019890

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
34804

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8954

UCSC genome browser

More...
UCSCi
CG8954-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53351.1
AE014134 Genomic DNA Translation: AAF53352.1
BT031137 mRNA Translation: ABX00759.1
AE014134 Genomic DNA Translation: AHN54428.1
AJ556817 mRNA Translation: CAD89222.1
RefSeqiNP_001285914.1, NM_001298985.1
NP_609685.1, NM_135841.5
NP_723851.1, NM_165069.2

3D structure databases

SMRiQ9V414
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9V414, 3 interactors
STRINGi7227.FBpp0080138

Proteomic databases

PRIDEiQ9V414

Genome annotation databases

EnsemblMetazoaiFBtr0080561; FBpp0080138; FBgn0019890
FBtr0080562; FBpp0080139; FBgn0019890
FBtr0343669; FBpp0310261; FBgn0019890
GeneIDi34804
KEGGidme:Dmel_CG8954
UCSCiCG8954-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23381
FlyBaseiFBgn0019890 Smg5

Phylogenomic databases

eggNOGiENOG410INQY Eukaryota
ENOG410XPF4 LUCA
GeneTreeiENSGT00940000154566
KOiK11125
OMAiVRTKKCI
OrthoDBi184090at2759

Enzyme and pathway databases

ReactomeiR-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
34804

Gene expression databases

BgeeiFBgn0019890 Expressed in 48 organ(s), highest expression level in brain

Family and domain databases

InterProiView protein in InterPro
IPR018834 DNA/RNA-bd_Est1-type
IPR019458 EST1
IPR002716 PIN_dom
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF10374 EST1, 1 hit
PF10373 EST1_DNA_bind, 1 hit
PF13638 PIN_4, 1 hit
SMARTiView protein in SMART
SM00670 PINc, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9V414_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9V414
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 16, 2019
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again