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UniProtKB - Q9V407 (AXN_DROME)
Protein
Axin
Gene
Axn
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Inhibitor of the WG signaling pathway. Down-regulates beta-catenin (armadillo=ARM). Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (zeste-white 3=ZW3).
1 PublicationGO - Molecular functioni
- beta-catenin binding Source: FlyBase
- molecular adaptor activity Source: FlyBase
- protein kinase binding Source: FlyBase
- signaling receptor binding Source: FlyBase
GO - Biological processi
- chitin-based larval cuticle pattern formation Source: FlyBase
- dorsal/ventral pattern formation, imaginal disc Source: FlyBase
- eye-antennal disc morphogenesis Source: FlyBase
- glycogen metabolic process Source: FlyBase
- heart development Source: FlyBase
- imaginal disc-derived wing margin morphogenesis Source: FlyBase
- negative regulation of canonical Wnt signaling pathway Source: FlyBase
- oogenesis Source: FlyBase
- ovarian follicle cell development Source: FlyBase
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: FlyBase
- regulation of cell death Source: FlyBase
- response to starvation Source: FlyBase
- segment polarity determination Source: FlyBase
- somatic stem cell population maintenance Source: FlyBase
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
Reactomei | R-DME-195253, Degradation of beta-catenin by the destruction complex R-DME-196299, Beta-catenin phosphorylation cascade R-DME-201681, TCF dependent signaling in response to WNT R-DME-209155, Phosphorylation of AXN and APC R-DME-209190, Phosphorylation of CI R-DME-209214, Phosphorylation of SMO R-DME-209360, Ubiquitination and proteolysis of phosphorylated CI R-DME-209396, Phosphorylation of ARM R-DME-209413, Assembly of the 'destruction complex' R-DME-209440, Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209461, Ubiquitination and degradation of phosphorylated ARM R-DME-432553, Phosphorylation of PER and TIM R-DME-4641257, Degradation of AXIN R-DME-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-DME-5689880, Ub-specific processing proteases |
SignaLinki | Q9V407 |
Names & Taxonomyi
Protein namesi | Recommended name: AxinAlternative name(s): Axis inhibition protein d-Axin Short name: dAxin |
Gene namesi | Name:Axn ORF Names:CG7926 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0026597, Axn |
VEuPathDBi | VectorBase:FBgn0026597 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: FlyBase
Nucleus
- nucleus Source: FlyBase
Plasma Membrane
- plasma membrane Source: FlyBase
Other locations
- beta-catenin destruction complex Source: FlyBase
- cytoplasm Source: FlyBase
- Wnt signalosome Source: FlyBase
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220894 | 1 – 745 | AxinAdd BLAST | 745 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 513 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 517 | Phosphoserine1 Publication | 1 | |
Modified residuei | 522 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9V407 |
PRIDEi | Q9V407 |
PTM databases
iPTMneti | Q9V407 |
Expressioni
Developmental stagei
Ubiquitously expressed throughout the development.
Gene expression databases
Bgeei | FBgn0026597, Expressed in brain and 19 other tissues |
ExpressionAtlasi | Q9V407, baseline and differential |
Genevisiblei | Q9V407, DM |
Interactioni
Subunit structurei
Interacts with ZW3 and ARM. The interaction between AXN and ARM occurs via the armadillo repeats contained in ARM.
GO - Molecular functioni
- beta-catenin binding Source: FlyBase
- protein kinase binding Source: FlyBase
- signaling receptor binding Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 68421, 37 interactors |
DIPi | DIP-20929N |
IntActi | Q9V407, 2 interactors |
MINTi | Q9V407 |
STRINGi | 7227.FBpp0084919 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 172 | RGSPROSITE-ProRule annotationAdd BLAST | 119 | |
Domaini | 663 – 745 | DIXPROSITE-ProRule annotationAdd BLAST | 83 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 45 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 183 – 204 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 243 – 275 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 339 – 401 | DisorderedSequence analysisAdd BLAST | 63 | |
Regioni | 508 – 581 | DisorderedSequence analysisAdd BLAST | 74 | |
Regioni | 593 – 663 | DisorderedSequence analysisAdd BLAST | 71 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 17 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 183 – 202 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 345 – 387 | Polar residuesSequence analysisAdd BLAST | 43 | |
Compositional biasi | 563 – 581 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 606 – 625 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 628 – 652 | Polar residuesSequence analysisAdd BLAST | 25 |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
InParanoidi | Q9V407 |
OMAi | YVYTAST |
OrthoDBi | 1481971at2759 |
PhylomeDBi | Q9V407 |
Family and domain databases
Gene3Di | 1.10.167.10, 1 hit 1.10.196.10, 1 hit 2.40.240.130, 1 hit |
InterProi | View protein in InterPro IPR043581, Axin-like IPR014936, Axin_b-cat-bd IPR001158, DIX IPR038207, DIX_dom_sf IPR016137, RGS IPR036305, RGS_sf IPR024066, RGS_subdom1/3 IPR044926, RGS_subdomain_2 IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR46102, PTHR46102, 1 hit |
Pfami | View protein in Pfam PF08833, Axin_b-cat_bind, 1 hit PF00778, DIX, 1 hit PF00615, RGS, 1 hit |
SMARTi | View protein in SMART SM00021, DAX, 1 hit SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50841, DIX, 1 hit PS50132, RGS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q9V407-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGHPSGIRK HDDNECSGPR PPVPGEESRV KKMTEGVADT SKNSSPSYLN
60 70 80 90 100
WARTLNHLLE DRDGVELFKK YVEEEAPAYN DHLNFYFACE GLKQQTDPEK
110 120 130 140 150
IKQIIGAIYR FLRKSQLSIS DDLRAQIKAI KTNPEIPLSP HIFDPMQRHV
160 170 180 190 200
EVTIRDNIYP TFLCSEMYIL YIQQMSAQQE RCTSSGATGS GSAGSSGSGG
210 220 230 240 250
SSLAGACALP PTTASGKQQL PQLVPPGAFI NLPVSSVSGP PAGTCSASGS
260 270 280 290 300
VYGPSTSASS SGSISATDTL PRSSTLPTLH EDSVLSLCDD FEKVQMQEGG
310 320 330 340 350
GSLGSGSVGA GARAPDYPIR LTRDLLIATQ KRRLEIRPPG AHGYVYNPST
360 370 380 390 400
TNTSYVPNSR VDSERASVSS GGRTDSDTMS ISSCSMDGRP YIQRRHSSTE
410 420 430 440 450
SKAIRQSAMA NKETNTFQVI PRTQRLHSNE HRPLKEEELV SLLIPKLEEV
460 470 480 490 500
KRKRDLEERA RERNPGAALL TNERSSASDR AFAEAIREKF ALDEDNDQDI
510 520 530 540 550
LDQHVSRVWK DQTPHRSPGT MSPCPPIPSR RRTATHDSGM VSDGAMSLSG
560 570 580 590 600
HSMKHSKSMP DHSSCSRKLT NKWPSMNTDS GISMFSADTV TKYKDASSRS
610 620 630 640 650
GSSTASKLEE AKRRLEDEPR RSRRYAQPPM QHLSQQPLAS FSSSSSGGSI
660 670 680 690 700
SLPHQPPPLP AKPPETIVVF SFCEEPVPYR IKIPGTQPTL RQFKDYLPRR
710 720 730 740
GHFRFFFKTH CEDPDSPVIQ EEIVNDSDIL PLFGDKAMGL VKPSD
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7Z0S0 | B7Z0S0_DROME | Axin, isoform D | Axn 0442, 30, APC, axin, axn | 699 | Annotation score: | ||
A4V3M5 | A4V3M5_DROME | Axin, isoform B | Axn 0442, 30, APC, axin, axn | 745 | Annotation score: | ||
Q8IMJ7 | Q8IMJ7_DROME | Axin, isoform C | Axn 0442, 30, APC, axin, axn | 739 | Annotation score: | ||
A0A0B4KHW0 | A0A0B4KHW0_DROME | Axin, isoform F | Axn 0442, 30, APC, axin, axn | 693 | Annotation score: | ||
E1JJ18 | E1JJ18_DROME | Axin, isoform E | Axn 0442, 30, APC, axin, axn | 110 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 454 | R → Q in AAD24886 (PubMed:10073940).Curated | 1 | |
Sequence conflicti | 644 – 645 | Missing in AAD24886 (PubMed:10073940).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF086811 mRNA Translation: AAD24886.1 AF091813 mRNA Translation: AAF21293.1 AE014297 Genomic DNA Translation: AAF56993.1 |
RefSeqi | NP_733336.1, NM_170457.3 NP_733337.1, NM_170458.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0085553; FBpp0084919; FBgn0026597 FBtr0085555; FBpp0084921; FBgn0026597 |
GeneIDi | 43565 |
KEGGi | dme:Dmel_CG7926 |
UCSCi | CG7926-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF086811 mRNA Translation: AAD24886.1 AF091813 mRNA Translation: AAF21293.1 AE014297 Genomic DNA Translation: AAF56993.1 |
RefSeqi | NP_733336.1, NM_170457.3 NP_733337.1, NM_170458.2 |
3D structure databases
SMRi | Q9V407 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 68421, 37 interactors |
DIPi | DIP-20929N |
IntActi | Q9V407, 2 interactors |
MINTi | Q9V407 |
STRINGi | 7227.FBpp0084919 |
PTM databases
iPTMneti | Q9V407 |
Proteomic databases
PaxDbi | Q9V407 |
PRIDEi | Q9V407 |
Genome annotation databases
EnsemblMetazoai | FBtr0085553; FBpp0084919; FBgn0026597 FBtr0085555; FBpp0084921; FBgn0026597 |
GeneIDi | 43565 |
KEGGi | dme:Dmel_CG7926 |
UCSCi | CG7926-RA, d. melanogaster |
Organism-specific databases
CTDi | 43565 |
FlyBasei | FBgn0026597, Axn |
VEuPathDBi | VectorBase:FBgn0026597 |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
InParanoidi | Q9V407 |
OMAi | YVYTAST |
OrthoDBi | 1481971at2759 |
PhylomeDBi | Q9V407 |
Enzyme and pathway databases
Reactomei | R-DME-195253, Degradation of beta-catenin by the destruction complex R-DME-196299, Beta-catenin phosphorylation cascade R-DME-201681, TCF dependent signaling in response to WNT R-DME-209155, Phosphorylation of AXN and APC R-DME-209190, Phosphorylation of CI R-DME-209214, Phosphorylation of SMO R-DME-209360, Ubiquitination and proteolysis of phosphorylated CI R-DME-209396, Phosphorylation of ARM R-DME-209413, Assembly of the 'destruction complex' R-DME-209440, Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209461, Ubiquitination and degradation of phosphorylated ARM R-DME-432553, Phosphorylation of PER and TIM R-DME-4641257, Degradation of AXIN R-DME-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-DME-5689880, Ub-specific processing proteases |
SignaLinki | Q9V407 |
Miscellaneous databases
BioGRID-ORCSi | 43565, 0 hits in 3 CRISPR screens |
GenomeRNAii | 43565 |
PROi | PR:Q9V407 |
Gene expression databases
Bgeei | FBgn0026597, Expressed in brain and 19 other tissues |
ExpressionAtlasi | Q9V407, baseline and differential |
Genevisiblei | Q9V407, DM |
Family and domain databases
Gene3Di | 1.10.167.10, 1 hit 1.10.196.10, 1 hit 2.40.240.130, 1 hit |
InterProi | View protein in InterPro IPR043581, Axin-like IPR014936, Axin_b-cat-bd IPR001158, DIX IPR038207, DIX_dom_sf IPR016137, RGS IPR036305, RGS_sf IPR024066, RGS_subdom1/3 IPR044926, RGS_subdomain_2 IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR46102, PTHR46102, 1 hit |
Pfami | View protein in Pfam PF08833, Axin_b-cat_bind, 1 hit PF00778, DIX, 1 hit PF00615, RGS, 1 hit |
SMARTi | View protein in SMART SM00021, DAX, 1 hit SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50841, DIX, 1 hit PS50132, RGS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AXN_DROME | |
Accessioni | Q9V407Primary (citable) accession number: Q9V407 Secondary accession number(s): Q9XYC1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase