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Protein
Submitted name:

26S proteasome regulatory complex subunit p48A

Gene

Rpt3

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseImported
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.4.25.1 1994
ReactomeiR-DME-1169091 Activation of NF-kappaB in B cells
R-DME-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-DME-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DME-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DME-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DME-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DME-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-202424 Downstream TCR signaling
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-209406 Degradation of NF-kappa-B inhibitor, CACT
R-DME-209461 Ubiquitination and degradation of phosphorylated ARM
R-DME-216167 Nuclear CI is degraded
R-DME-2871837 FCERI mediated NF-kB activation
R-DME-432395 Degradation of TIM
R-DME-432524 Degradation of PER
R-DME-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DME-4608870 Asymmetric localization of PCP proteins
R-DME-4641257 Degradation of AXIN
R-DME-4641258 Degradation of DVL
R-DME-5358346 Hedgehog ligand biogenesis
R-DME-538848 Degradation of CLK
R-DME-538864 Degradation of CRY
R-DME-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764 CLEC7A (Dectin-1) signaling
R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
R-DME-5632684 Hedgehog 'on' state
R-DME-5658442 Regulation of RAS by GAPs
R-DME-5676590 NIK-->noncanonical NF-kB signaling
R-DME-5689603 UCH proteinases
R-DME-5689880 Ub-specific processing proteases
R-DME-68949 Orc1 removal from chromatin
R-DME-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DME-69229 Ubiquitin-dependent degradation of Cyclin D1
R-DME-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DME-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DME-8939902 Regulation of RUNX2 expression and activity
R-DME-8941858 Regulation of RUNX3 expression and activity
R-DME-8948751 Regulation of PTEN stability and activity
R-DME-9020702 Interleukin-1 signaling
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
26S proteasome regulatory complex subunit p48AImported
Submitted name:
CG16916 proteinImported
Submitted name:
GH06151pImported
Submitted name:
Regulatory particle triple-A ATPase 3, isoform AImported
Submitted name:
Regulatory particle triple-A ATPase 3, isoform BImported (EC:3.-.-.-Imported, EC:3.6.1.3Imported)
Gene namesi
Name:Rpt3Imported
Synonyms:16916Imported, Dm_Rpt3aImported, Dmel\CG16916Imported, Dmp48AImported, l(1)G0052Imported, p48AImported, Rpt3-RAImported, S6Imported, S6BImported, TBP7Imported
ORF Names:CG16916Imported, Dmel_CG16916Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0028686 Rpt3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ProteasomeImported

PTM / Processingi

Proteomic databases

PRIDEiQ9V405

Expressioni

Gene expression databases

BgeeiFBgn0028686

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9V405, 17 interactors
STRINGi7227.FBpp0073292

Structurei

3D structure databases

SMRiQ9V405
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini193 – 332AAAInterPro annotationAdd BLAST140

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili32 – 52Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the AAA ATPase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0727 Eukaryota
COG1222 LUCA
GeneTreeiENSGT00550000074962
KOiK03063
OMAiLIIRNDP
OrthoDBiEOG091G07NC

Family and domain databases

InterProiView protein in InterPro
IPR005937 26S_Psome_P45-like
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR001270 ClpA/B
IPR027417 P-loop_NTPase
IPR035256 PSMC4
PANTHERiPTHR23073:SF8 PTHR23073:SF8, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PRINTSiPR00300 CLPPROTEASEA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01242 26Sp45, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9V405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYNMDVLIP EKDELSDLKL KDAHSSLDEL DMEDLYVRYK KLQKTLEFIE
60 70 80 90 100
VQEEYIKDEQ RNLKKEYLHA QEEVKRIQSV PLVIGQFLEA VDQNTGIVGS
110 120 130 140 150
TTGSNYYVRI LSTIDRELLK PSASVALHKH SNALVDVLPP EADSSISMLQ
160 170 180 190 200
PDEKPDVSYA DIGGMDMQKQ EIREAVELPL THFELYKQIG IDPPRGVLMY
210 220 230 240 250
GPPGCGKTML AKAVAHHTTA SFIRVVGSEF VQKYLGEGPR MVRDVFRLAK
260 270 280 290 300
ENAPAIIFID EIDAIATKRF DAQTGADREV QRILLELLNQ MDGFDQTTNV
310 320 330 340 350
KVIMATNRAD TLDPALLRPG RLDRKIEFPL PDRRQKRLVF STITSKMNLS
360 370 380 390 400
EDVDLEEFVA RPDKISGADI NAICQEAGMH AVRENRYIVL AKDFEKGYKN
410
NIKKDEQEHE FYK
Length:413
Mass (Da):46,999
Last modified:May 1, 2000 - v1
Checksum:i34E7518BE593A0E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145306 mRNA Translation: AAF08387.1
AE014298 Genomic DNA Translation: AAF48001.1
BT046144 mRNA Translation: ACI46532.1
AE014298 Genomic DNA Translation: AHN59578.1
FN544098 Genomic DNA Translation: CBA35179.1
FN544099 Genomic DNA Translation: CBA35180.1
FN544100 Genomic DNA Translation: CBA35181.1
FN544101 Genomic DNA Translation: CBA35182.1
FN544102 Genomic DNA Translation: CBA35183.1
FN544103 Genomic DNA Translation: CBA35184.1
FN544104 Genomic DNA Translation: CBA35185.1
FN544105 Genomic DNA Translation: CBA35186.1
FN544106 Genomic DNA Translation: CBA35187.1
FN544108 Genomic DNA Translation: CBA35189.1
RefSeqiNP_001285108.1, NM_001298179.1
NP_572686.1, NM_132458.3
UniGeneiDm.8238

Genome annotation databases

EnsemblMetazoaiFBtr0073436; FBpp0073292; FBgn0028686
FBtr0346274; FBpp0312031; FBgn0028686
GeneIDi32047
KEGGidme:Dmel_CG16916
UCSCiCG16916-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9V405_DROME
AccessioniPrimary (citable) accession number: Q9V405
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 18, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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