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Entry version 150 (11 Dec 2019)
Sequence version 1 (01 May 2000)
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Protein

Myosin-VIIa

Gene

ck

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Myosins are actin-based motor molecules with ATPase activity (PubMed:16585515). Unconventional myosins serve in intracellular movements: can function in cells as a single-molecule cargo transporter (PubMed:16585515). A very slow and high-duty-ratio motor, may be suitable for tension maintenance of actin filaments (PubMed:16585515). Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (PubMed:15579689). Plays a key role in the formation of cellular projections and other actin-based functions required for embryonic and larval viability (PubMed:15579689, PubMed:16585515). Necessary for auditory transduction: plays a role in Johnston's organ organization by functioning in scolopidial apical attachment and therefore to acoustic stimulus propagation from the antenna a2/a3 joint to transducing elements (PubMed:15886106, PubMed:27331610). Interaction with the myosin zip may be important for its function in scolopidial apical attachment (PubMed:27331610). During oogenesis it has Cad99c-dependent and Cad99c-independent roles in regulating the shape and spacing of the follicle cell microvilli which secrete eggshell material such as the vitelline membrane (PubMed:25236597). May be required for the normal expression of Cad99c in the follicle cell microvilli (PubMed:25236597).5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi156 – 163ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin-VIIa
Short name:
DmVIIa
Alternative name(s):
Protein crinkled
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ckImported
ORF Names:CG7595
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0000317 ck

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Flies exhibit altered morphology of setae, micro- and macrochaetae on the head, thorax and wing (PubMed:15579689). The number and distribution of setae on the thorax is altered, as is the morphology of the aristae (PubMed:15579689). Mutants also exhibit scolopidial apical detachment and overall Johnston's organ (JO) disorganization (PubMed:15579689). RNAi-mediated knockdown in Johnston's organs, disrupts the filamentous structure of the glycoprotein NompA at the apical junction (PubMed:27331610). NompA occurs as puncta and scolopidia detatch from the hinge of the second and third antennal segment (PubMed:27331610).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003063761 – 2167Myosin-VIIaAdd BLAST2167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1651Phosphoserine1 Publication1
Modified residuei1654Phosphoserine1 Publication1
Modified residuei2045Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9V3Z6

PRoteomics IDEntifications database

More...
PRIDEi
Q9V3Z6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9V3Z6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the setae, micro- and macrochaetae on the head, thorax and wing.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Throughout oogenesis expressed in the germline and associated somatic cells (at protein level) (PubMed:25236597). In germline cells of the germarium, expression levels peak during follicle formation and again from mid-oogenesis until late oogenesis (at protein level). Expressed both maternally and zygotically (PubMed:15579689). Expression peaks in 12-18 hour embryos, and continues at a constant low level of expression through to adults (PubMed:15579689).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0000317 Expressed in 30 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9V3Z6 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9V3Z6 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimerizes in a two headed molecule through the formation of a coiled-coil rod (PubMed:16585515). Homodimers motility is approximately 8-10 times slower than that of myosin V, and its step size is 30 nm, which is consistent with the presence of five IQ motifs in its neck region (PubMed:16585515).

Interacts with Cad99C (via the cytoplasmic domain) (PubMed:25236597, PubMed:27331610).

Interacts with zip and Sans (PubMed:27331610).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P621523EBI-15762145,EBI-182924

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
60900, 14 interactors

Database of interacting proteins

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DIPi
DIP-48747N

Protein interaction database and analysis system

More...
IntActi
Q9V3Z6, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0080282

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9V3Z6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini63 – 733Myosin motorPROSITE-ProRule annotationAdd BLAST671
Domaini736 – 758IQ 1PROSITE-ProRule annotationCuratedAdd BLAST23
Domaini759 – 788IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini805 – 827IQ 3PROSITE-ProRule annotationCuratedAdd BLAST23
Domaini828 – 857IQ 4PROSITE-ProRule annotationAdd BLAST30
Domaini1008 – 1245MyTH4 1PROSITE-ProRule annotationAdd BLAST238
Domaini1250 – 1560FERM 1PROSITE-ProRule annotationAdd BLAST311
Domaini1558 – 1627SH3PROSITE-ProRule annotationAdd BLAST70
Domaini1701 – 1849MyTH4 2PROSITE-ProRule annotationAdd BLAST149
Domaini1855 – 2158FERM 2PROSITE-ProRule annotationAdd BLAST304

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni612 – 634Actin-bindingBy similarityAdd BLAST23
Regioni712 – 726Actin-bindingBy similarityAdd BLAST15

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili886 – 919Sequence analysisAdd BLAST34

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4229 Eukaryota
COG5022 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155350

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9V3Z6

KEGG Orthology (KO)

More...
KOi
K10359

Identification of Orthologs from Complete Genome Data

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OMAi
FNIEEAH

Database of Orthologous Groups

More...
OrthoDBi
527681at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9V3Z6

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473 FERM_B-lobe, 2 hits
cd13198 FERM_C1_MyoVII, 1 hit
cd13199 FERM_C2_MyoVII, 1 hit
cd01381 MYSc_Myo7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 2 hits
1.25.40.530, 2 hits
2.30.29.30, 2 hits
2.30.30.360, 1 hit
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR008989 Myosin_S1_N
IPR041793 MyoVII_FERM_C1
IPR041794 MyoVII_FERM_C2
IPR036106 MYSc_Myo7
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00373 FERM_M, 1 hit
PF00612 IQ, 4 hits
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295 B41, 2 hits
SM00015 IQ, 4 hits
SM00242 MYSc, 1 hit
SM00139 MyTH4, 2 hits
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031 SSF47031, 2 hits
SSF50044 SSF50044, 1 hit
SSF52540 SSF52540, 2 hits
SSF54236 SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057 FERM_3, 2 hits
PS50096 IQ, 4 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 2 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9V3Z6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVIVTRGDYI WIEPASGREF DVAIGARVVS AEGRRIQVRD DDGDEVWLAP
60 70 80 90 100
ERRIKAMHAS SVQGVEDMIS LGDLHEAGIL RNLLIRYKEN LIYTYTGSIL
110 120 130 140 150
VAVNPYQILP IYTGDQIKLY KERKIGELPP HIFAIGDNAY AHMKRYRQDQ
160 170 180 190 200
CIVISGESGA GKTESTKLIL QYLAAISGKH SWIEQQILEA NPILEAFGNA
210 220 230 240 250
KTIRNDNSSR FGKYIDIHFS ANGVIEGAKI EQYLLEKSRI VSQNHSERNY
260 270 280 290 300
HVFYCILAGL SADEKSRLDL GMAADYKYLT GGNSITCEGR DDAAEFSDIR
310 320 330 340 350
SAMKVLLFSD QEIWEIIKLL AALLHCGNIK YKATVVDNLD ATEIPEHINV
360 370 380 390 400
ERVAGLLGLP IQPLIDALTR RTLFAHGETV VSTLSRDQSV DVRDAFVKGI
410 420 430 440 450
YGRMFVHIVR KINTAIFKPR GTSRNAIGVL DIFGFENFDQ NSFEQFCINY
460 470 480 490 500
ANENLQQFFV QHIFKLEQEE YNHEAINWQH IEFVDNQDAL DLIAIKQLNI
510 520 530 540 550
MALIDEEARF PKGTDQTMLA KLHKTHGSHK NYLKPKSDIN TSFGLNHFAG
560 570 580 590 600
VVFYDTRGFL DKNRDTFSPD LLHLVSQSTN KFLRQIFAQD IEMGAETRKR
610 620 630 640 650
TPTLSTQFRK SLDALMKTLS SCQPFFIRCI KPNELKKPMM FDRGLCCRQL
660 670 680 690 700
RYSGMMETIR IRRAGYPIRH GFREFVERYR FLIPGVPPAH RTDCQAATSR
710 720 730 740 750
ICAVVLGKSD YQLGHTKVFL KDAHDLFLEQ ERDRVLTRKI LILQRSIRGW
760 770 780 790 800
VYRRRFLRLR AAAITVQRFW KGYAQRKRYR NMRVGYMRLQ ALIRSRVLSH
810 820 830 840 850
RFRHLRGHIV GLQAHARGYL VRREYGHKMW AVIKIQSHVR RMIAMRRYRK
860 870 880 890 900
LRLEHKQFAE VLQLRKLEEQ ELLHRGNKHA REIAEQHYRD RLHELERREI
910 920 930 940 950
QEQLENRRRV EVNMNIINDA ARKQEEPVDD GKLVEAMFDF LPDSSSDAPT
960 970 980 990 1000
PHGGRETSVF NDLPHAQNVN QDDIIAPIHI SEDEEDLSEF KFQKFAATYF
1010 1020 1030 1040 1050
QGNVNHQYAK KALKHPLLPL HTQGDQLAAQ ALWITILRFT GDMPEPKYHT
1060 1070 1080 1090 1100
MDRMDTTSVM SKVTATLGRN FIRSKEFQEA QLMGLDPDAF LKQKPRSIRH
1110 1120 1130 1140 1150
KLVSLTLKRK NKLGEDVRRR LQDDEYTADS YQSWLQSRPT SNLEKLHFII
1160 1170 1180 1190 1200
GHGILRAELR DEIYCQICKQ LTNNPLKSSH ARGWILLSLC VGCFAPSEKF
1210 1220 1230 1240 1250
VNYLRAFIRE GPPGYAPYCE ERLKRTFNNG TRNQPPSWLE LQATKSKKPI
1260 1270 1280 1290 1300
MLPITFMDGN TKTLLADSAT TARELCNQLS DKISLKDQFG FSLYIALFDK
1310 1320 1330 1340 1350
VSSLGSGGDH VMDAISQCEQ YAKEQGAQER NAPWRLFFRK EIFAPWHEPT
1360 1370 1380 1390 1400
HDQVATNLIY QQVVRGVKFG EYRCDKEEDL AMIAAQQYFI EYSTDMSMER
1410 1420 1430 1440 1450
LFTLLPNFIP DFCLSGVDKA IERWAALVLQ AYKKSYYVKD KIAPLKIKED
1460 1470 1480 1490 1500
IVSYAKYKWP LLFSRFYEAY RNSGPNLPKN DVIIAVNWTG VYVVDDQEQV
1510 1520 1530 1540 1550
LLELSFPEIT AVSSQKTNKV FTQTFSLSTV RGEEFTFQSP NAEDIRDLVV
1560 1570 1580 1590 1600
YFLDGLKKRS KYVIALQDYR APSDGTSFLS FFKGDLIILE DESCGESVLN
1610 1620 1630 1640 1650
NGWCIGRCDR SQERGDFPAE TVYVLPTLSK PPQDILALFN IEEAHHGRRL
1660 1670 1680 1690 1700
SMASNGGAVE PRDRPHTLME YALDHFRLPP KRTMSKTLTL SSKRSEELWR
1710 1720 1730 1740 1750
YSRDPIKAPL LRKLQSKEEF AEEACFAFAA ILKYMGDLPS KRPRMGNEIT
1760 1770 1780 1790 1800
DHIFDGPLKH EILRDEIYCQ LMKQLTDNRN RMSEERGWEL MWLATGLFAC
1810 1820 1830 1840 1850
SQGLLKELLL FLRTRRHPIS QDSMHRLQKT IRHGQRKYPP HQVEVEAIQH
1860 1870 1880 1890 1900
KTTQIFHKVY FPDDTDEAFE VDSSTRAKDF CNNISQRLSL RTSEGFSLFV
1910 1920 1930 1940 1950
KIADKVISVP EGDFFFDFVR HLTDWIKKAR PIRDGANPQF TYQVFFMKKL
1960 1970 1980 1990 2000
WTNTVPGKDR NADLIFHYHQ ELPKLLRGYH KCSREEAAKL AALVFRVRFG
2010 2020 2030 2040 2050
ENKQELQAIP QMLRELIPSD IMKIQSTSEW KRSIVASYNQ DGGMTSEDAK
2060 2070 2080 2090 2100
VAFLKIVYRW PTFGSAFFEV KQTTEPNYPE MLLIAINKHG VSLIHPVTKD
2110 2120 2130 2140 2150
ILVTHPFTRI SNWSSGNTYF HMTIGNLVRG SKLLCETSLG YKMDDLLTSY
2160
ISLMLTNMNK NRTIRAN
Length:2,167
Mass (Da):250,309
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C57E34ADDD89A42
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G7H829G7H829_DROME
Crinkled, isoform C
ck 53D10S, anon-35Bb, BG:DS00929.11, br27, CK
2,167Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2024I → M in AAR96124 (Ref. 4) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53435.1
AE014134 Genomic DNA Translation: AAN10886.1
AY069438 mRNA Translation: AAL39583.2
BT011332 mRNA Translation: AAR96124.1

NCBI Reference Sequences

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RefSeqi
NP_001285949.1, NM_001299020.1
NP_001285950.1, NM_001299021.1
NP_523571.1, NM_078847.4
NP_723895.1, NM_165099.3

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0080723; FBpp0080282; FBgn0000317
FBtr0080724; FBpp0080283; FBgn0000317
FBtr0343686; FBpp0310274; FBgn0000317
FBtr0343687; FBpp0310275; FBgn0000317

Database of genes from NCBI RefSeq genomes

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GeneIDi
34882

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG7595

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53435.1
AE014134 Genomic DNA Translation: AAN10886.1
AY069438 mRNA Translation: AAL39583.2
BT011332 mRNA Translation: AAR96124.1
RefSeqiNP_001285949.1, NM_001299020.1
NP_001285950.1, NM_001299021.1
NP_523571.1, NM_078847.4
NP_723895.1, NM_165099.3

3D structure databases

SMRiQ9V3Z6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi60900, 14 interactors
DIPiDIP-48747N
IntActiQ9V3Z6, 2 interactors
STRINGi7227.FBpp0080282

PTM databases

iPTMnetiQ9V3Z6

Proteomic databases

PaxDbiQ9V3Z6
PRIDEiQ9V3Z6

Genome annotation databases

EnsemblMetazoaiFBtr0080723; FBpp0080282; FBgn0000317
FBtr0080724; FBpp0080283; FBgn0000317
FBtr0343686; FBpp0310274; FBgn0000317
FBtr0343687; FBpp0310275; FBgn0000317
GeneIDi34882
KEGGidme:Dmel_CG7595

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
34882
FlyBaseiFBgn0000317 ck

Phylogenomic databases

eggNOGiKOG4229 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000155350
InParanoidiQ9V3Z6
KOiK10359
OMAiFNIEEAH
OrthoDBi527681at2759
PhylomeDBiQ9V3Z6

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
34882

Protein Ontology

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PROi
PR:Q9V3Z6

Gene expression databases

BgeeiFBgn0000317 Expressed in 30 organ(s), highest expression level in embryo
ExpressionAtlasiQ9V3Z6 differential
GenevisibleiQ9V3Z6 DM

Family and domain databases

CDDicd14473 FERM_B-lobe, 2 hits
cd13198 FERM_C1_MyoVII, 1 hit
cd13199 FERM_C2_MyoVII, 1 hit
cd01381 MYSc_Myo7, 1 hit
Gene3Di1.20.80.10, 2 hits
1.25.40.530, 2 hits
2.30.29.30, 2 hits
2.30.30.360, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR008989 Myosin_S1_N
IPR041793 MyoVII_FERM_C1
IPR041794 MyoVII_FERM_C2
IPR036106 MYSc_Myo7
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF00612 IQ, 4 hits
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 2 hits
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00295 B41, 2 hits
SM00015 IQ, 4 hits
SM00242 MYSc, 1 hit
SM00139 MyTH4, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47031 SSF47031, 2 hits
SSF50044 SSF50044, 1 hit
SSF52540 SSF52540, 2 hits
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 2 hits
PS50096 IQ, 4 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 2 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYO7A_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9V3Z6
Secondary accession number(s): Q6NNF6, Q8T0A9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 1, 2000
Last modified: December 11, 2019
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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