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Protein
Submitted name:

GH11341p

Gene

Rpn5

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

BRENDAi3.4.25.1 1994
ReactomeiR-DME-1169091 Activation of NF-kappaB in B cells
R-DME-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-DME-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DME-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DME-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DME-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DME-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-202424 Downstream TCR signaling
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-209406 Degradation of NF-kappa-B inhibitor, CACT
R-DME-209461 Ubiquitination and degradation of phosphorylated ARM
R-DME-216167 Nuclear CI is degraded
R-DME-2871837 FCERI mediated NF-kB activation
R-DME-432395 Degradation of TIM
R-DME-432524 Degradation of PER
R-DME-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DME-4608870 Asymmetric localization of PCP proteins
R-DME-4641257 Degradation of AXIN
R-DME-4641258 Degradation of DVL
R-DME-5358346 Hedgehog ligand biogenesis
R-DME-538848 Degradation of CLK
R-DME-538864 Degradation of CRY
R-DME-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764 CLEC7A (Dectin-1) signaling
R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
R-DME-5632684 Hedgehog 'on' state
R-DME-5658442 Regulation of RAS by GAPs
R-DME-5676590 NIK-->noncanonical NF-kB signaling
R-DME-5689603 UCH proteinases
R-DME-5689880 Ub-specific processing proteases
R-DME-6798695 Neutrophil degranulation
R-DME-68949 Orc1 removal from chromatin
R-DME-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DME-69229 Ubiquitin-dependent degradation of Cyclin D1
R-DME-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DME-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DME-8939902 Regulation of RUNX2 expression and activity
R-DME-8941858 Regulation of RUNX3 expression and activity
R-DME-8948751 Regulation of PTEN stability and activity
R-DME-9020702 Interleukin-1 signaling
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
GH11341pImported
Submitted name:
Hypothetical 55kDa proteinImported
Submitted name:
Regulatory particle non-ATPase 5Imported
Gene namesi
Name:Rpn5Imported
Synonyms:Dmel\CG1100Imported, p55Imported, rpn5Imported
ORF Names:CG1100Imported, Dmel_CG1100Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0028690 Rpn5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ9V3Z4

Expressioni

Gene expression databases

BgeeiFBgn0028690

Interactioni

Protein-protein interaction databases

IntActiQ9V3Z4, 17 interactors
STRINGi7227.FBpp0078278

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini286 – 461PCIInterPro annotationAdd BLAST176

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili293 – 313Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1498 Eukaryota
COG5071 LUCA
GeneTreeiENSGT00730000111110
KOiK03035
OMAiKQAITKM
OrthoDBiEOG091G06CB

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000717 PCI_dom
IPR035297 PSMD12
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10855:SF1 PTHR10855:SF1, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequencei

Sequence statusi: Complete.

Q9V3Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTYLFDGGR ITKMEVDYEP ACNEKIPLAK ELAKKNPDAF HEAIEMMLQL
60 70 80 90 100
EKQTRLGADM VSCSRVLVAI CQICFDASNW NALNEYVSLL VRRRSQLKQA
110 120 130 140 150
VVKMIQECVT YVDKTPDKET KLKLIDTLRS VTEGKIYVEI ERARLTKILA
160 170 180 190 200
DIKEADGDVA GAATVMEELQ VETYGSMDKR EKVELILEQM RLCLLKEDYV
210 220 230 240 250
STQIIAKKIS IKFFDDPAQH DLKLKFYYLM IQLNRDTSFL NTSRHYQAIA
260 270 280 290 300
EPPRKKTGLT PVDSAASTDE QKKKDDDKKK KEEDDKDKKP EVATEAEVEI
310 320 330 340 350
ELTEEQKKEL TEKLVCAVLY CVLAPFDNEQ SDMMAHLSKN KKLEEVPAYK
360 370 380 390 400
EILRLFMSKE LINFDTFNAD FGLVLAENEM FKDSTKHGKK CITELKDRLI
410 420 430 440 450
EHNIRIIAMY YSRLHLARMS ELLNLPTSRC EEYLSKLANT DTIRVKIDRP
460 470 480 490 500
AGIIYFTQKK SASDILNNWA TDVNQLMSLV NKTCHLINKE ECVYSVMCAV

ED
Length:502
Mass (Da):57,748
Last modified:May 1, 2000 - v1
Checksum:i3DAF2C42C35FBDEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145315 mRNA Translation: AAF08383.1
AE014297 Genomic DNA Translation: AAF51952.1
AY058339 mRNA Translation: AAL13568.1
RefSeqiNP_649588.1, NM_141331.3
UniGeneiDm.3426

Genome annotation databases

EnsemblMetazoaiFBtr0078629; FBpp0078278; FBgn0028690
GeneIDi40717
KEGGidme:Dmel_CG1100
UCSCiCG1100-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9V3Z4_DROME
AccessioniPrimary (citable) accession number: Q9V3Z4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 18, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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