The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q9V3U6 (Q9V3U6_DROME)
Protein
Submitted name:
26-29kD-proteinase
Gene
26-29-p
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: FlyBase
- cysteine-type peptidase activity Source: FlyBase
GO - Biological processi
- positive regulation of Toll signaling pathway Source: FlyBase
- proteolysis involved in cellular protein catabolic process Source: GO_Central
- zymogen activation Source: FlyBase
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseARBA annotation |
Protein family/group databases
MEROPSi | C01.067 |
Names & Taxonomyi
Protein namesi | Submitted name: 26-29kD-proteinaseImported (EC:3.4.22.-Imported)Submitted name: Homologue of Sarcophaga 26,29kDa proteinaseImportedSubmitted name: RE18380pImported |
Gene namesi | Name:26-29-pImported Synonyms:26Imported, 26-29kD-proteinaseImported, 29kD-proteinaseImported, anon-SAGE:Wang-123Imported, Dmel\CG8947Imported, l(3)s3635Imported ORF Names:CG8947Imported, Dmel_CG8947Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0250848, 26-29-p |
VEuPathDBi | VectorBase:FBgn0250848 |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: FlyBase
Lysosome
- lysosome Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_5015020158 | 20 – 549 | Sequence analysisAdd BLAST | 530 |
Keywords - PTMi
ZymogenARBA annotationExpressioni
Gene expression databases
Bgeei | FBgn0250848, Expressed in arthropod fat body and 41 other tissues |
Interactioni
Protein-protein interaction databases
IntActi | Q9V3U6, 7 interactors |
STRINGi | 7227.FBpp0075508 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 245 – 301 | Inhibitor_I29InterPro annotationAdd BLAST | 57 | |
Domaini | 330 – 548 | Pept_C1InterPro annotationAdd BLAST | 219 |
Sequence similaritiesi
Belongs to the peptidase C1 family.ARBA annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
eggNOGi | KOG1543, Eukaryota |
GeneTreei | ENSGT00940000163923 |
HOGENOMi | CLU_012184_11_0_1 |
OMAi | KAFHHFK |
OrthoDBi | 1275401at2759 |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
Pfami | View protein in Pfam PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9V3U6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQVFLALALL AGLAFSANAT NPPKWDPNYI VKGTLYIPYA EIAEPFYAWY
60 70 80 90 100
DKNTRRSRID YYGGMVKTYQ LAGEGQYGTL LKLAPITTKT ENNKLTCLQV
110 120 130 140 150
NGTADQAVDI QSILPDAKPF SLVGTESFLG YTCDKFRLES TIGQKKNIYT
160 170 180 190 200
LWVRYKKSPH YPSSRMPIPV RYEMRGYNTL LGSHYDHYYL DYDSYEHDDI
210 220 230 240 250
PNEVFEIDDS LQCVGFPGPG TGHYATFNPM QEFISGTDEH VDKAFHHFKR
260 270 280 290 300
KHGVAYHSDT EHEHRKNIFR QNLRYIHSKN RAKLTYTLAV NHLADKTEEE
310 320 330 340 350
LKARRGYKSS GIYNTGKPFP YDVPKYKDEI PDQYDWRLYG AVTPVKDQSV
360 370 380 390 400
CGSCWSFGTI GHLEGAFFLK NGGNLVRLSQ QALIDCSWAY GNNGCDGGED
410 420 430 440 450
FRVYQWMLQS GGVPTEEEYG PYLGQDGYCH VNNVTLVAPI KGFVNVTSND
460 470 480 490 500
PNAFKLALLK HGPLSVAIDA SPKTFSFYSH GVYYEPTCKN DVDGLDHAVL
510 520 530 540
AVGYGSINGE DYWLVKNSWS TYWGNDGYIL MSAKKNNCGV MTMPTYVEM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF49777.1 AY122222 mRNA Translation: AAM52734.1 AB011376 mRNA Translation: BAA86910.1 |
RefSeqi | NP_620470.1, NM_138985.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0075766; FBpp0075508; FBgn0250848 |
GeneIDi | 39547 |
KEGGi | dme:Dmel_CG8947 |
UCSCi | CG8947-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF49777.1 AY122222 mRNA Translation: AAM52734.1 AB011376 mRNA Translation: BAA86910.1 |
RefSeqi | NP_620470.1, NM_138985.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q9V3U6, 7 interactors |
STRINGi | 7227.FBpp0075508 |
Protein family/group databases
MEROPSi | C01.067 |
Protocols and materials databases
DNASUi | 39547 |
Genome annotation databases
EnsemblMetazoai | FBtr0075766; FBpp0075508; FBgn0250848 |
GeneIDi | 39547 |
KEGGi | dme:Dmel_CG8947 |
UCSCi | CG8947-RA, d. melanogaster |
Organism-specific databases
CTDi | 39547 |
FlyBasei | FBgn0250848, 26-29-p |
VEuPathDBi | VectorBase:FBgn0250848 |
Phylogenomic databases
eggNOGi | KOG1543, Eukaryota |
GeneTreei | ENSGT00940000163923 |
HOGENOMi | CLU_012184_11_0_1 |
OMAi | KAFHHFK |
OrthoDBi | 1275401at2759 |
Miscellaneous databases
BioGRID-ORCSi | 39547, 0 hits in 1 CRISPR screen |
ChiTaRSi | 26-29-p, fly |
GenomeRNAii | 39547 |
Gene expression databases
Bgeei | FBgn0250848, Expressed in arthropod fat body and 41 other tissues |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
Pfami | View protein in Pfam PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9V3U6_DROME | |
Accessioni | Q9V3U6Primary (citable) accession number: Q9V3U6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | January 19, 2022 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |