UniProtKB - Q9V3R8 (UBIA1_DROME)
Protein
UbiA prenyltransferase domain-containing protein 1 homolog
Gene
heix
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Prenyltransferase that mediates the formation of menaquinone-4 (MK-4), a vitamin K2 isoform, thereby acting as a mitochondrial electron carrier. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. MK-4 acts as a membrane electron carrier downstream of a electron transport chain complex, improving mitochondrial oxygen consumption.1 Publication
: menaquinone biosynthesis Pathwayi
This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.
GO - Molecular functioni
- prenyltransferase activity Source: GO_Central
GO - Biological processi
- larval lymph gland hemopoiesis Source: FlyBase
- menaquinone biosynthetic process Source: FlyBase
- mitochondrion morphogenesis Source: FlyBase
- negative regulation of hemocyte differentiation Source: FlyBase
- negative regulation of hemocyte proliferation Source: FlyBase
- negative regulation of lamellocyte differentiation Source: FlyBase
- ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate Source: GO_Central
- vitamin K biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Prenyltransferase, Transferase |
Biological process | Menaquinone biosynthesis |
Enzyme and pathway databases
Reactomei | R-DME-6806664, Metabolism of vitamin K |
UniPathwayi | UPA00079 |
Names & Taxonomyi
Protein namesi | Recommended name: UbiA prenyltransferase domain-containing protein 1 homolog (EC:2.5.1.-)Alternative name(s): Protein heixuedian |
Gene namesi | Name:heix ORF Names:CG5876 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0028375, heix |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: FlyBase
Golgi apparatus
- integral component of Golgi membrane Source: GO_Central
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
- mitochondrion Source: FlyBase
Other locations
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 67 – 89 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 98 – 118 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 148 – 168 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 177 – 197 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 200 – 220 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 262 – 284 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 289 – 311 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 335 – 355 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000242631 | 1 – 359 | UbiA prenyltransferase domain-containing protein 1 homologAdd BLAST | 359 |
Proteomic databases
PaxDbi | Q9V3R8 |
PRIDEi | Q9V3R8 |
Expressioni
Gene expression databases
Bgeei | FBgn0028375, Expressed in embryo and 19 other tissues |
Genevisiblei | Q9V3R8, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 60972, 6 interactors |
IntActi | Q9V3R8, 1 interactor |
STRINGi | 7227.FBpp0080409 |
Family & Domainsi
Sequence similaritiesi
Belongs to the UbiA prenyltransferase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4581, Eukaryota |
GeneTreei | ENSGT00390000012439 |
HOGENOMi | CLU_043611_0_0_1 |
InParanoidi | Q9V3R8 |
OMAi | PMAFPLE |
OrthoDBi | 1146311at2759 |
PhylomeDBi | Q9V3R8 |
Family and domain databases
CDDi | cd13962, PT_UbiA_UBIAD1, 1 hit |
InterProi | View protein in InterPro IPR000537, UbiA_prenyltransferase IPR026046, UBIAD1 |
Pfami | View protein in Pfam PF01040, UbiA, 1 hit |
PIRSFi | PIRSF005355, UBIAD1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9V3R8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATSSQLLPN GNLSRNGKTK TEDGEEVEAV VGARAAGADA GVALTGRLTG
60 70 80 90 100
HPSTSGTFMK LKTYLLALRP WSLSASLVPT LLGSALAYRS QWAEEFSLAT
110 120 130 140 150
FFLTAFTVVT VHCAGNVVNT YFDFIKGIDK QKADDRTLVD HILTKDEVVS
160 170 180 190 200
LGAILYMAGC GGFVLLAVLS PAKMEHLALI YFGGLSSSFL YTGGIGFKYI
210 220 230 240 250
ALGDLVILIL FGPISVLFAF MSQTGHLDWT TMGYAIPLAL NTEAILHSNN
260 270 280 290 300
TRDADNDRRA GIVTLAILIG RTASHVLYAM LLFAPYSLFF IFGLKYSLWF
310 320 330 340 350
LLPLVTLPQA FQIEKRFRNE QTMHLVPRQT AKLNFFFGIL YVVACCCAHQ
LPTFGLRRN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF440356 mRNA Translation: AAL34085.1 AE014134 Genomic DNA Translation: AAF53515.1 AY061093 mRNA Translation: AAL28641.1 |
RefSeqi | NP_523581.1, NM_078857.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0080852; FBpp0080409; FBgn0028375 |
GeneIDi | 34961 |
KEGGi | dme:Dmel_CG5876 |
UCSCi | CG5876-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF440356 mRNA Translation: AAL34085.1 AE014134 Genomic DNA Translation: AAF53515.1 AY061093 mRNA Translation: AAL28641.1 |
RefSeqi | NP_523581.1, NM_078857.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 60972, 6 interactors |
IntActi | Q9V3R8, 1 interactor |
STRINGi | 7227.FBpp0080409 |
Proteomic databases
PaxDbi | Q9V3R8 |
PRIDEi | Q9V3R8 |
Genome annotation databases
EnsemblMetazoai | FBtr0080852; FBpp0080409; FBgn0028375 |
GeneIDi | 34961 |
KEGGi | dme:Dmel_CG5876 |
UCSCi | CG5876-RA, d. melanogaster |
Organism-specific databases
CTDi | 34961 |
FlyBasei | FBgn0028375, heix |
Phylogenomic databases
eggNOGi | KOG4581, Eukaryota |
GeneTreei | ENSGT00390000012439 |
HOGENOMi | CLU_043611_0_0_1 |
InParanoidi | Q9V3R8 |
OMAi | PMAFPLE |
OrthoDBi | 1146311at2759 |
PhylomeDBi | Q9V3R8 |
Enzyme and pathway databases
UniPathwayi | UPA00079 |
Reactomei | R-DME-6806664, Metabolism of vitamin K |
Miscellaneous databases
BioGRID-ORCSi | 34961, 1 hit in 1 CRISPR screen |
GenomeRNAii | 34961 |
PROi | PR:Q9V3R8 |
Gene expression databases
Bgeei | FBgn0028375, Expressed in embryo and 19 other tissues |
Genevisiblei | Q9V3R8, DM |
Family and domain databases
CDDi | cd13962, PT_UbiA_UBIAD1, 1 hit |
InterProi | View protein in InterPro IPR000537, UbiA_prenyltransferase IPR026046, UBIAD1 |
Pfami | View protein in Pfam PF01040, UbiA, 1 hit |
PIRSFi | PIRSF005355, UBIAD1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBIA1_DROME | |
Accessioni | Q9V3R8Primary (citable) accession number: Q9V3R8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families