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Entry version 177 (17 Jun 2020)
Sequence version 1 (01 May 2000)
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Protein
Submitted name:

Drab5

Gene

Rab5

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activity Source: FlyBase
  • GTP binding Source: InterPro

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-6798695 Neutrophil degranulation
R-DME-8854214 TBC/RABGAPs
R-DME-8856828 Clathrin-mediated endocytosis
R-DME-8873719 RAB geranylgeranylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Drab5Imported
Submitted name:
GH24702pImported
Submitted name:
Rab5Imported
Submitted name:
Rab5 proteinImported
Submitted name:
Rab5, isoform AImported
Submitted name:
Rab5, isoform BImported
Submitted name:
Rab5, isoform CImported
Submitted name:
Rab5, isoform EImported
Submitted name:
Rab5, isoform FImported
Submitted name:
Rab5, isoform HImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rab5Imported
Synonyms:AAF51265Imported, BAA88244Imported, Dm Rab5Imported, Dmel\CG3664Imported, DmRab5Imported, DRab5Imported, Drab5Imported, dRab5Imported, drab5Imported, l(2)k08232Imported, RabImported, Rab-5Imported, RAB5Imported, rab5Imported, RAB5aImported
ORF Names:CG3664Imported, Dmel_CG3664Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0014010 Rab5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0014010 Expressed in embryonic/larval hemocyte (Drosophila) and 47 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9V3I2, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0077473

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9V3I2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24
Regioni194 – 219DisorderedSequence analysisAdd BLAST26

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0092 Eukaryota
ENOG410YCCP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154971

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_041217_10_2_1

KEGG Orthology (KO)

More...
KOi
K07889

Identification of Orthologs from Complete Genome Data

More...
OMAi
DTFHDNT

Database of Orthologous Groups

More...
OrthoDBi
1340129at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00071 Ras, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00231 small_GTP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9V3I2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATTPRSGGA SGTGTAQRPN GTSQNKSCQF KLVLLGESAV GKSSLVLRFV
60 70 80 90 100
KGQFHEYQES TIGAAFLTQT ICIEDTVVKF EIWDTAGQER YHSLAPMYYR
110 120 130 140 150
GAQAAIVVYD IQNQDSFQRA KTWVKELHKQ ASPNIVIALA GNKADLSNIR
160 170 180 190 200
VVEFDEAKQY AEENGLLFME TSAKTGMNVN DIFLAIAKKL PKNDGANNQG
210
TSIRPTGTET NRPTNNCCK
Length:219
Mass (Da):23,959
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFA3A28955B7F15D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF51265.1
AY060343 mRNA Translation: AAL25382.1
AE014134 Genomic DNA Translation: AAN10422.1
AE014134 Genomic DNA Translation: AAN10423.1
AE014134 Genomic DNA Translation: AAN10424.1
AE014134 Genomic DNA Translation: AAN10425.1
AE014134 Genomic DNA Translation: AAN10426.1
AY081180 mRNA Translation: AAN85552.1
AY081181 mRNA Translation: AAN85553.1
AE014134 Genomic DNA Translation: AGB92462.1
AE014134 Genomic DNA Translation: AGB92463.1
AE014134 Genomic DNA Translation: AGB92464.1
AB035353 mRNA Translation: BAA87879.1
AB035671 mRNA Translation: BAA88244.1
BK000968 Genomic DNA Translation: DAA01061.1

NCBI Reference Sequences

More...
RefSeqi
NP_001259925.1, NM_001272996.1
NP_001259926.1, NM_001272997.1
NP_001259927.1, NM_001272998.1
NP_523457.1, NM_078733.4
NP_722795.1, NM_164475.2
NP_722796.1, NM_164476.2
NP_722797.1, NM_164477.3
NP_722798.1, NM_164478.2
NP_722799.1, NM_164479.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0077793; FBpp0077470; FBgn0014010
FBtr0077794; FBpp0077471; FBgn0014010
FBtr0077795; FBpp0077472; FBgn0014010
FBtr0077796; FBpp0077473; FBgn0014010
FBtr0077797; FBpp0077474; FBgn0014010
FBtr0077798; FBpp0077475; FBgn0014010
FBtr0330668; FBpp0303518; FBgn0014010
FBtr0330669; FBpp0303519; FBgn0014010
FBtr0330670; FBpp0303520; FBgn0014010

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33418

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG3664

UCSC genome browser

More...
UCSCi
CG3664-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF51265.1
AY060343 mRNA Translation: AAL25382.1
AE014134 Genomic DNA Translation: AAN10422.1
AE014134 Genomic DNA Translation: AAN10423.1
AE014134 Genomic DNA Translation: AAN10424.1
AE014134 Genomic DNA Translation: AAN10425.1
AE014134 Genomic DNA Translation: AAN10426.1
AY081180 mRNA Translation: AAN85552.1
AY081181 mRNA Translation: AAN85553.1
AE014134 Genomic DNA Translation: AGB92462.1
AE014134 Genomic DNA Translation: AGB92463.1
AE014134 Genomic DNA Translation: AGB92464.1
AB035353 mRNA Translation: BAA87879.1
AB035671 mRNA Translation: BAA88244.1
BK000968 Genomic DNA Translation: DAA01061.1
RefSeqiNP_001259925.1, NM_001272996.1
NP_001259926.1, NM_001272997.1
NP_001259927.1, NM_001272998.1
NP_523457.1, NM_078733.4
NP_722795.1, NM_164475.2
NP_722796.1, NM_164476.2
NP_722797.1, NM_164477.3
NP_722798.1, NM_164478.2
NP_722799.1, NM_164479.2

3D structure databases

SMRiQ9V3I2
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9V3I2, 3 interactors
STRINGi7227.FBpp0077473

Genome annotation databases

EnsemblMetazoaiFBtr0077793; FBpp0077470; FBgn0014010
FBtr0077794; FBpp0077471; FBgn0014010
FBtr0077795; FBpp0077472; FBgn0014010
FBtr0077796; FBpp0077473; FBgn0014010
FBtr0077797; FBpp0077474; FBgn0014010
FBtr0077798; FBpp0077475; FBgn0014010
FBtr0330668; FBpp0303518; FBgn0014010
FBtr0330669; FBpp0303519; FBgn0014010
FBtr0330670; FBpp0303520; FBgn0014010
GeneIDi33418
KEGGidme:Dmel_CG3664
UCSCiCG3664-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
33418
FlyBaseiFBgn0014010 Rab5

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
GeneTreeiENSGT00940000154971
HOGENOMiCLU_041217_10_2_1
KOiK07889
OMAiDTFHDNT
OrthoDBi1340129at2759

Enzyme and pathway databases

ReactomeiR-DME-6798695 Neutrophil degranulation
R-DME-8854214 TBC/RABGAPs
R-DME-8856828 Clathrin-mediated endocytosis
R-DME-8873719 RAB geranylgeranylation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
33418 1 hit in 5 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rab5 fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
33418

Gene expression databases

BgeeiFBgn0014010 Expressed in embryonic/larval hemocyte (Drosophila) and 47 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9V3I2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9V3I2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 17, 2020
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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