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Protein

26S proteasome non-ATPase regulatory subunit 6

Gene

Rpn7

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.By similarity

GO - Molecular functioni

GO - Biological processi

  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: FlyBase

Enzyme and pathway databases

BRENDAi3.4.25.1 1994
ReactomeiR-DME-1169091 Activation of NF-kappaB in B cells
R-DME-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-DME-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DME-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DME-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DME-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DME-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-202424 Downstream TCR signaling
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-209406 Degradation of NF-kappa-B inhibitor, CACT
R-DME-209461 Ubiquitination and degradation of phosphorylated ARM
R-DME-216167 Nuclear CI is degraded
R-DME-2871837 FCERI mediated NF-kB activation
R-DME-432395 Degradation of TIM
R-DME-432524 Degradation of PER
R-DME-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DME-4608870 Asymmetric localization of PCP proteins
R-DME-4641257 Degradation of AXIN
R-DME-4641258 Degradation of DVL
R-DME-5358346 Hedgehog ligand biogenesis
R-DME-538848 Degradation of CLK
R-DME-538864 Degradation of CRY
R-DME-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764 CLEC7A (Dectin-1) signaling
R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
R-DME-5632684 Hedgehog 'on' state
R-DME-5658442 Regulation of RAS by GAPs
R-DME-5676590 NIK-->noncanonical NF-kB signaling
R-DME-5689603 UCH proteinases
R-DME-5689880 Ub-specific processing proteases
R-DME-6798695 Neutrophil degranulation
R-DME-68949 Orc1 removal from chromatin
R-DME-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DME-69229 Ubiquitin-dependent degradation of Cyclin D1
R-DME-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DME-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DME-8939902 Regulation of RUNX2 expression and activity
R-DME-8941858 Regulation of RUNX3 expression and activity
R-DME-8948751 Regulation of PTEN stability and activity
R-DME-9020702 Interleukin-1 signaling
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 6
Alternative name(s):
26S proteasome regulatory subunit S10
Protein Rpn7
Gene namesi
Name:Rpn7
ORF Names:CG5378
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0028688 Rpn7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738411 – 38926S proteasome non-ATPase regulatory subunit 6Add BLAST389

Proteomic databases

PaxDbiQ9V3G7
PRIDEiQ9V3G7

Expressioni

Gene expression databases

BgeeiFBgn0028688
GenevisibleiQ9V3G7 DM

Interactioni

Protein-protein interaction databases

BioGridi67596, 34 interactors
DIPiDIP-23841N
IntActiQ9V3G7, 8 interactors
STRINGi7227.FBpp0083687

Structurei

3D structure databases

ProteinModelPortaliQ9V3G7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini193 – 361PCIPROSITE-ProRule annotationAdd BLAST169

Sequence similaritiesi

Belongs to the proteasome subunit S10 family.Curated

Phylogenomic databases

eggNOGiKOG0687 Eukaryota
COG5187 LUCA
GeneTreeiENSGT00510000046608
InParanoidiQ9V3G7
KOiK03037
OMAiVDYIDQE
OrthoDBiEOG091G03SE
PhylomeDBiQ9V3G7

Family and domain databases

InterProiView protein in InterPro
IPR000717 PCI_dom
IPR035268 PSMD6
IPR019585 Rpn7/CSN1
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR14145:SF1 PTHR14145:SF1, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
PF10602 RPN7, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequencei

Sequence statusi: Complete.

Q9V3G7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAENLEEQG LEKNPNLELA QTKFLLTLAE YKQDAALKAK LLEAIRTENM
60 70 80 90 100
APWYEHICSE LGWTVDKDLL ARMKENNRVE VEQLDAAIED AEKNLGEMEV
110 120 130 140 150
REANLKKSEY LCRIGDKAAA ETAFRKTYEK TVSLGHRLDI VFHLIRLGLF
160 170 180 190 200
YLDHDLITRN IDKAKYLIEE GGDWDRRNRL KVYQGVYSVA VRDFKAAATF
210 220 230 240 250
FLDTVSTFTS YELMDYPTFV RYTVYVAMIA LPRNELRDKV IKGSEIQEVL
260 270 280 290 300
HGLPDVKQFL FSLYNCQYEN FYVHLAGVEK QLRLDYLIHP HYRYYVREMR
310 320 330 340 350
ILGYTQLLES YRSLTLQYMA ESFGVTVEYI DQELARFIAA GRLHAKVDRV
360 370 380
GGIVETNRPD NKNWQYQATI KQGDLLLNRI QKLSRVINI
Length:389
Mass (Da):45,381
Last modified:May 1, 2000 - v1
Checksum:iCCC1DE0C7393B6FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145308 mRNA Translation: AAF08389.1
AE014297 Genomic DNA Translation: AAF56000.1
AY052008 mRNA Translation: AAK93432.1
RefSeqiNP_651048.1, NM_142791.3
UniGeneiDm.3424

Genome annotation databases

EnsemblMetazoaiFBtr0084294; FBpp0083687; FBgn0028688
GeneIDi42641
KEGGidme:Dmel_CG5378
UCSCiCG5378-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiPSMD6_DROME
AccessioniPrimary (citable) accession number: Q9V3G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: May 1, 2000
Last modified: July 18, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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