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Entry version 175 (02 Dec 2020)
Sequence version 1 (01 May 2000)
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Protein

Structural maintenance of chromosomes protein

Gene

glu

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-2299718, Condensation of Prophase Chromosomes
R-DME-2514853, Condensation of Prometaphase Chromosomes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Structural maintenance of chromosomes proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gluImported
Synonyms:anon-WO0118547.156Imported, BcDNA.LD20207Imported, BcDNA:LD20207Imported, Dmel\CG11397Imported, DmSMC4Imported, dSMC4Imported, GluImported, GluonImported, gluonImported, l(2)k08819Imported, SMC4Imported, Smc4Imported
ORF Names:CG11397Imported, Dmel_CG11397Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0015391, glu

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9V3A7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0015391, Expressed in embryo and 39 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9V3A7, 13 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0080489

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9V3A7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini618 – 734SMC hingeInterPro annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 46DisorderedSequence analysisAdd BLAST46
Regioni973 – 1009DisorderedSequence analysisAdd BLAST37
Regioni1380 – 1409DisorderedSequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili272 – 299Sequence analysisAdd BLAST28
Coiled coili374 – 394Sequence analysisAdd BLAST21
Coiled coili409 – 436Sequence analysisAdd BLAST28
Coiled coili444 – 471Sequence analysisAdd BLAST28
Coiled coili497 – 517Sequence analysisAdd BLAST21
Coiled coili532 – 552Sequence analysisAdd BLAST21
Coiled coili783 – 845Sequence analysisAdd BLAST63
Coiled coili863 – 911Sequence analysisAdd BLAST49
Coiled coili1125 – 1145Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 40PolarSequence analysisAdd BLAST19
Compositional biasi973 – 996PolyampholyteSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SMC family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0996, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00900000141094

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001042_4_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VGHYIKE

Database of Orthologous Groups

More...
OrthoDBi
326079at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03274, ABC_SMC4_euk, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417, P-loop_NTPase
IPR003395, RecF/RecN/SMC_N
IPR024704, SMC
IPR041738, SMC4_ABC_euk
IPR010935, SMC_hinge
IPR036277, SMC_hinge_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06470, SMC_hinge, 1 hit
PF02463, SMC_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005719, SMC, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00968, SMC_hinge, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit
SSF75553, SSF75553, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9V3A7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKARPSKGT PKAAGGARQS GQFRVPQLTA QQQLRAQQQQ EEEDAAVDAL
60 70 80 90 100
DDALIFDDEE GGTRIGDIYI PPPVPPHCSM ESTGPRLIIS KIVNRNFKSY
110 120 130 140 150
AGEVELGPFH QSFTAIIGPN GSGKSNVIDS MMFVFGCRAN RIRCKRVSTL
160 170 180 190 200
IHSSSSYPNL RSCSVAVHFK QIVDKGDGTC EDVPDSSIVI ERTAMSDNSS
210 220 230 240 250
YYQINDKRAQ LKDVAKLLKK HHVDLEHNRF LILQGEVESI AMMKPKGQTE
260 270 280 290 300
NETGMLEYLE DIVGTQRYIR PLQQINQRVD QLTDDRTEKH NRCKLAEREM
310 320 330 340 350
KDLEQPFNEA VDYLKKENEL VRTKSFHIQK IISIKKSKLE QYTQEHEACA
360 370 380 390 400
EELKTHDEGT AALKQSRAEK ETIIRKEIEE YEALVKKREQ IKKRLVTVES
410 420 430 440 450
AYTEIQSTME NTNKQRKKDK AQIEKNEKEL EDLHKLPEKN QREIEDCNKK
460 470 480 490 500
LESLEVSKVT LNEELEKQQA ELTKTTAPLT EKRLKLSDEL VGLKEKVNTA
510 520 530 540 550
KGEVQVFESQ LKILKQAETT ESRKYETLKS SYEQSQKSLE EKVTRVDELK
560 570 580 590 600
ESIPRMKTEI ASKSAEVDKM VKEERNLSMQ CNKLRTEINE RSSVMQAQRS
610 620 630 640 650
NNKVLDFLMR MKMEGKIPGI LGRLGDLGGI DAKYDIAIST ACGRLDNIVT
660 670 680 690 700
DNYETASAAI GALKEYNVGR ATFITLDKIE HHRREANSRI NTPENVPRLY
710 720 730 740 750
DLVKVEDDRV RTAFYFALRN TLVCDDLEQG TRIAYGRERY RVVTLRGEMI
760 770 780 790 800
EMTGTMSGGG SRPIRGKMGT QVRTKTAESA DSSQISQKAL EDMQIQAEEL
810 820 830 840 850
QARVNYCQEQ QGSLEREIQT LKNGLQRDEA EYKRLAVSIT SLEQQMASNL
860 870 880 890 900
KQCEAQRQRM LKKTTDERAV KEREEQIEAA KQELEQAQFA EQAVSSQIEE
910 920 930 940 950
IQNQYDTLRN ESVKPVEAKI KKVNSQIEKL AANVRSLNVG LATADRNITK
960 970 980 990 1000
ITGNNNNLRE NIKAAEEKLK SLNEDRNKAK EKKEELEKEI EESEASIEGA
1010 1020 1030 1040 1050
KSQSSDIKKE IDEITKEENK RNIERIEIDT KLQAAAGKMN KVKNDIPGWQ
1060 1070 1080 1090 1100
AQLAPLKLNE IPGETEPQAP LKELNEEELE AETLEALQYK QTMLEEDLKT
1110 1120 1130 1140 1150
KKPNLSCIKE FNEKRLVYLD RVRVLEDITS KRNEMRDKYE EVRKRRYKEF
1160 1170 1180 1190 1200
MDGFSIITRK LKEMYQMITL GGDAELELVD SMDPFTEGVN FTVRPPKKSW
1210 1220 1230 1240 1250
KYISNLSGGE KTLSSLALVF ALHYYKPSPL YFMDEIDAAL DFKNVSIVGH
1260 1270 1280 1290 1300
YIKERTKNAQ FIIVSLRVNM FELANFLVGI YKVSDCTDSI TMLNYPPTLP
1310 1320 1330 1340 1350
TQSPVVANSQ YVGGTIEGDN TIAAENQDDT PTKKSQSPPS EQIVRLISEL
1360 1370 1380 1390 1400
GRDTTFAPPL ESTVRDTILA QNLKQAATEV AAQPSDATGR VTTDVSLASP

PSSPAILNV
Length:1,409
Mass (Da):159,883
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF606069751842AFE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF186472 mRNA Translation: AAF01416.1
AE014134 Genomic DNA Translation: AAF53560.1
BT031125 mRNA Translation: ABX00747.1

NCBI Reference Sequences

More...
RefSeqi
NP_723996.1, NM_165180.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0080935; FBpp0080489; FBgn0015391

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
35001

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG11397

UCSC genome browser

More...
UCSCi
CG11397-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186472 mRNA Translation: AAF01416.1
AE014134 Genomic DNA Translation: AAF53560.1
BT031125 mRNA Translation: ABX00747.1
RefSeqiNP_723996.1, NM_165180.2

3D structure databases

SMRiQ9V3A7
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9V3A7, 13 interactors
STRINGi7227.FBpp0080489

Proteomic databases

PRIDEiQ9V3A7

Genome annotation databases

EnsemblMetazoaiFBtr0080935; FBpp0080489; FBgn0015391
GeneIDi35001
KEGGidme:Dmel_CG11397
UCSCiCG11397-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
35001
FlyBaseiFBgn0015391, glu

Phylogenomic databases

eggNOGiKOG0996, Eukaryota
GeneTreeiENSGT00900000141094
HOGENOMiCLU_001042_4_1_1
OMAiVGHYIKE
OrthoDBi326079at2759

Enzyme and pathway databases

ReactomeiR-DME-2299718, Condensation of Prophase Chromosomes
R-DME-2514853, Condensation of Prometaphase Chromosomes

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
35001, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
35001

Gene expression databases

BgeeiFBgn0015391, Expressed in embryo and 39 other tissues

Family and domain databases

CDDicd03274, ABC_SMC4_euk, 2 hits
InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR003395, RecF/RecN/SMC_N
IPR024704, SMC
IPR041738, SMC4_ABC_euk
IPR010935, SMC_hinge
IPR036277, SMC_hinge_sf
PfamiView protein in Pfam
PF06470, SMC_hinge, 1 hit
PF02463, SMC_N, 1 hit
PIRSFiPIRSF005719, SMC, 2 hits
SMARTiView protein in SMART
SM00968, SMC_hinge, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
SSF75553, SSF75553, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9V3A7_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9V3A7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: December 2, 2020
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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