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Protein

Fructose-bisphosphate aldolase class 1

Gene

fba

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Activity regulationi

Activated by citrate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei191Schiff-base intermediate with dihydroxyacetone-PBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

BioCyciPABY272844:G1GT8-103-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1 (EC:4.1.2.13)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolase
Gene namesi
Name:fba
Ordered Locus Names:PYRAB00890
ORF Names:PAB0049
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001389481 – 281Fructose-bisphosphate aldolase class 1Add BLAST281

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

STRINGi272844.PAB0049

Structurei

3D structure databases

ProteinModelPortaliQ9V2I6
SMRiQ9V2I6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family.Curated

Phylogenomic databases

eggNOGiarCOG04044 Archaea
COG1830 LUCA
HOGENOMiHOG000224790
KOiK11645
OMAiFVKVNYP
OrthoDBiPOG093Z070T

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR002915 DeoC/FbaB/lacD_aldolase
PfamiView protein in Pfam
PF01791 DeoC, 1 hit
PIRSFiPIRSF038992 Aldolase_Ia, 1 hit
SMARTiView protein in SMART
SM01133 DeoC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9V2I6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEALQNIGIK RRLRRFFRRD GRALIFAMDH GFEHGPTDFE PVWEHVNPRV
60 70 80 90 100
IIRKVVRAGV DGVMMLPGMA RIAGDDVKPE VGLMIKITSK TNLRPKAEQL
110 120 130 140 150
MQSQLAFVED AIKLGADAIA ATVYWGSPQE DAMMRQFAEI VSYAHDLGFP
160 170 180 190 200
VVQFAYPRGP YIDEKYGRKE DYRVVMYGAR AAAEMGADMI KTYWTGSRET
210 220 230 240 250
FAKVVDAAAG VPVLLSGGAK AENPLDFLKV VYEVIEAGGS GAVVGRNIFQ
260 270 280
RENPEPMIKA LIRVIHRNED PEEAAKAEGL L
Length:281
Mass (Da):31,222
Last modified:May 1, 2000 - v1
Checksum:i6BFFCA8A4441D5A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248283 Genomic DNA Translation: CAB49012.1
HE613800 Genomic DNA Translation: CCE69464.1
PIRiE75195
RefSeqiWP_010867213.1, NC_000868.1

Genome annotation databases

EnsemblBacteriaiCAB49012; CAB49012; PAB0049
GeneIDi1494975
KEGGipab:PAB0049
PATRICifig|272844.11.peg.102

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248283 Genomic DNA Translation: CAB49012.1
HE613800 Genomic DNA Translation: CCE69464.1
PIRiE75195
RefSeqiWP_010867213.1, NC_000868.1

3D structure databases

ProteinModelPortaliQ9V2I6
SMRiQ9V2I6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272844.PAB0049

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB49012; CAB49012; PAB0049
GeneIDi1494975
KEGGipab:PAB0049
PATRICifig|272844.11.peg.102

Phylogenomic databases

eggNOGiarCOG04044 Archaea
COG1830 LUCA
HOGENOMiHOG000224790
KOiK11645
OMAiFVKVNYP
OrthoDBiPOG093Z070T

Enzyme and pathway databases

BioCyciPABY272844:G1GT8-103-MONOMER

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR002915 DeoC/FbaB/lacD_aldolase
PfamiView protein in Pfam
PF01791 DeoC, 1 hit
PIRSFiPIRSF038992 Aldolase_Ia, 1 hit
SMARTiView protein in SMART
SM01133 DeoC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALF1_PYRAB
AccessioniPrimary (citable) accession number: Q9V2I6
Secondary accession number(s): G8ZFS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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