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Protein

GPN-loop GTPase PAB0955

Gene

PYRAB14380

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Small GTPase that may be involved in genome maintenance. Has weak intrinsic GTPase activity but displays no ATPase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei67Stabilizes the phosphate intermediate; shared with dimeric partner1 Publication1
Binding sitei224GTP; via amide nitrogen1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15GTP1 Publication6
Nucleotide bindingi165 – 168GTP1 Publication4

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPABY272844:G1GT8-1581-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
GPN-loop GTPase PAB09551 Publication (EC:3.6.5.-1 Publication)
Gene namesi
Ordered Locus Names:PYRAB14380Imported
ORF Names:PAB0955Imported
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004312971 – 248GPN-loop GTPase PAB0955Add BLAST248

Interactioni

Subunit structurei

Homodimer (PubMed:16510996). Interacts with DNA topoisomerase VI subunit B (top6B), DNA primase DnaG and RF-C (PubMed:17468740).2 Publications

Protein-protein interaction databases

MINTiQ9UYR9
STRINGi272844.PAB0955

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiQ9UYR9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UYR9

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi65 – 67Gly-Pro-Asn (GPN)-loop; involved in dimer interface1 Publication3

Sequence similaritiesi

Belongs to the GPN-loop GTPase family.Curated

Phylogenomic databases

eggNOGiarCOG01225 Archaea
COG1100 LUCA
HOGENOMiHOG000110575
KOiK06883
OrthoDBiPOG093Z0AHK

Family and domain databases

InterProiView protein in InterPro
IPR004130 Gpn
IPR027417 P-loop_NTPase
PANTHERiPTHR21231 PTHR21231, 1 hit
PfamiView protein in Pfam
PF03029 ATP_bind_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UYR9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIVVFVGTAG SGKTTLTGEF GRYLEDNYKV AYVNLDTGVK ELPYEPSIDV
60 70 80 90 100
REFVTVEEIM REGYGPNGAI VESYDRLMEK FNEYLNKILR LEKENDYVLI
110 120 130 140 150
DTPGQMETFL FHEFGVRLME NLPYPLVVYI SDPEILKKPN DYCFVRFFAL
160 170 180 190 200
LIDLRLGATT IPALNKVDLL SEEEKERHRK YFEDIDYLTA RLKLDPSMQG
210 220 230 240
LMAYKMCSMM TEVLPPVRVL YLSAKTREGF EDLETLAYEH YCTCGDLT
Length:248
Mass (Da):28,697
Last modified:November 26, 2014 - v2
Checksum:iF88FB5473E40B0D3
GO

Sequence cautioni

The sequence CAB50343 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248287 Genomic DNA Translation: CAB50343.1 Different initiation.
HE613800 Genomic DNA Translation: CCE70884.1
PIRiB75056
RefSeqiWP_048147021.1, NC_000868.1

Genome annotation databases

EnsemblBacteriaiCAB50343; CAB50343; PAB0955
GeneIDi1495713
KEGGipab:PAB0955
PATRICifig|272844.11.peg.1529

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248287 Genomic DNA Translation: CAB50343.1 Different initiation.
HE613800 Genomic DNA Translation: CCE70884.1
PIRiB75056
RefSeqiWP_048147021.1, NC_000868.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YR6X-ray2.15A1-248[»]
1YR7X-ray2.08A1-248[»]
1YR8X-ray2.40A1-248[»]
1YR9X-ray2.80A1-248[»]
1YRAX-ray2.30A/B1-248[»]
1YRBX-ray1.75A/B1-248[»]
2OXRX-ray2.40A1-248[»]
SMRiQ9UYR9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiQ9UYR9
STRINGi272844.PAB0955

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB50343; CAB50343; PAB0955
GeneIDi1495713
KEGGipab:PAB0955
PATRICifig|272844.11.peg.1529

Phylogenomic databases

eggNOGiarCOG01225 Archaea
COG1100 LUCA
HOGENOMiHOG000110575
KOiK06883
OrthoDBiPOG093Z0AHK

Enzyme and pathway databases

BioCyciPABY272844:G1GT8-1581-MONOMER

Miscellaneous databases

EvolutionaryTraceiQ9UYR9

Family and domain databases

InterProiView protein in InterPro
IPR004130 Gpn
IPR027417 P-loop_NTPase
PANTHERiPTHR21231 PTHR21231, 1 hit
PfamiView protein in Pfam
PF03029 ATP_bind_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPN_PYRAB
AccessioniPrimary (citable) accession number: Q9UYR9
Secondary accession number(s): G8ZIK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 26, 2014
Last sequence update: November 26, 2014
Last modified: February 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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