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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.By similarity

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei173By similarity1
Active sitei200By similarity1
Active sitei296By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Enzyme and pathway databases

BioCyciPABY272844:G1GT8-1711-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase (EC:3.1.1.61)
Gene namesi
Name:cheB
Ordered Locus Names:PYRAB15550
ORF Names:PAB1331
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001580561 – 368Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei604-aspartylphosphateBy similarity1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9UYF3

Interactioni

Protein-protein interaction databases

STRINGi272844.PAB1331

Structurei

3D structure databases

ProteinModelPortaliQ9UYF3
SMRiQ9UYF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 126Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini161 – 354CheB-type methylesteraseAdd BLAST194

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.By similarity

Phylogenomic databases

eggNOGiarCOG02382 Archaea
COG2201 LUCA
HOGENOMiHOG000151424
KOiK03412
OMAiMLEMHRA
OrthoDBiPOG093Z00HE

Family and domain databases

CDDicd16432 CheB_Rec, 1 hit
cd00156 REC, 1 hit
Gene3Di3.40.50.180, 1 hit
HAMAPiMF_00099 CheB_methylest, 1 hit
InterProiView protein in InterPro
IPR035909 CheB_C
IPR011006 CheY-like_superfamily
IPR008248 Sig_transdc_resp-reg_CheB
IPR000673 Sig_transdc_resp-reg_Me-estase
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF01339 CheB_methylest, 1 hit
PF00072 Response_reg, 1 hit
PIRSFiPIRSF000876 RR_chemtxs_CheB, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
SSF52738 SSF52738, 1 hit
PROSITEiView protein in PROSITE
PS50122 CHEB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UYF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLTGRKIRV LVVDDSAFMR KVLKDIINSD PELEVCGEAR DGIEAIEMVQ
60 70 80 90 100
KCRPDVVTLD VEMPRMNGLD ALRVIMKKYP VPVIMISALT QEGAEATIKA
110 120 130 140 150
LEYGAIDFIP KPSSSISINM RELKDEIIAK IKEAAKVPRR FLELRRIRLL
160 170 180 190 200
RVQKAKKVKP SVPARIAVAI AASTGGPQSL LKIFPKFPEN LKAGILLVQH
210 220 230 240 250
MPPGFTRSFA KRLDSVSKID VKEAEEGDVV EEGKAYVAPG DYHMEVTLRG
260 270 280 290 300
GKPVITLNKK PKMHGVRPAA DPMMITAAQV FGRRTVGVVM TGMGRDGAQG
310 320 330 340 350
IVEIKKRGGI TIAQDEKTSI IFGMPKAAIE TGMVDYVVPL EKIPETVVRA
360
VEMIRGGGNL GRHVTIPR
Length:368
Mass (Da):40,313
Last modified:May 1, 2000 - v1
Checksum:i147655F99918D0AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248288 Genomic DNA Translation: CAB50459.1
HE613800 Genomic DNA Translation: CCE71009.1
PIRiE75002
RefSeqiWP_010868672.1, NC_000868.1

Genome annotation databases

EnsemblBacteriaiCAB50459; CAB50459; PAB1331
GeneIDi1495838
KEGGipab:PAB1331
PATRICifig|272844.11.peg.1654

Similar proteinsi

Entry informationi

Entry nameiCHEB_PYRAB
AccessioniPrimary (citable) accession number: Q9UYF3
Secondary accession number(s): G8ZIX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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