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UniProtKB - Q9UXF6 (RFCL_SACS2)
Protein
Replication factor C large subunit
Gene
rfcL
Organism
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Status
Functioni
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity.
2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 47 – 54 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- ATP hydrolysis activity Source: InterPro
- DNA clamp loader activity Source: UniProtKB-UniRule
GO - Biological processi
- DNA replication Source: UniProtKB-UniRule
Keywordsi
Biological process | DNA replication |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 3.6.4.B8, 6163 |
Names & Taxonomyi
Protein namesi | Recommended name: Replication factor C large subunitShort name: RFC large subunit Alternative name(s): Clamp loader large subunit SsoRFC large subunit |
Gene namesi | Name:rfcL Ordered Locus Names:SSO0769 ORF Names:C40_005 |
Organismi | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) |
Taxonomic identifieri | 273057 [NCBI] |
Taxonomic lineagei | Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Saccharolobus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000135966 | 1 – 405 | Replication factor C large subunitAdd BLAST | 405 |
Interactioni
Subunit structurei
Heteropentamer composed of four small subunits (RfcS) and one large subunit (RfcL). Probably interacts with PCNA subunit PCNA3.
2 PublicationsProtein-protein interaction databases
STRINGi | 273057.SSO0769 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | arCOG00470, Archaea |
HOGENOMi | CLU_027255_1_1_2 |
InParanoidi | Q9UXF6 |
OMAi | GGWTRYG |
PhylomeDBi | Q9UXF6 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
HAMAPi | MF_01508, RfcL, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003959, ATPase_AAA_core IPR027417, P-loop_NTPase IPR023935, Rep_factor-C_lsu |
Pfami | View protein in Pfam PF00004, AAA, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9UXF6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIQWFLKYRP RSLKDVENQD DAKKQLQEWI ESWLNGNSNV KAVLLHGPPG
60 70 80 90 100
VGKTVLAEAL AHDYNFELLE MNASDSRKLQ DIKSIAEKAA VYGSIFGTKG
110 120 130 140 150
KLILLDEVDG INVREDTGAI QGILELIEKT KYPIIMTAND PWNPGLRELR
160 170 180 190 200
NKAKMIELSK LGKYPLRRIL KKICQAEKII CDDEALNYII DSSEGDARYA
210 220 230 240 250
INILQGIGEG YGKVTLNLVE SLAKRKEREL DPFETLRDIF WARYAWQAKN
260 270 280 290 300
AATSAQIDYD MLIRWISENI PIQYDNIEDI WRAFDALSRA SIFLKRAKSG
310 320 330 340 350
DWDLLSYAYD MMSSGVAFAE PEKKKPNWKP KWKKYQFPSY IQLLSKSKDI
360 370 380 390 400
RDTRDEIIKK LAIHSSFNKA LNDTYPFFLL FYKKYDKHLN LNTKEKEYLS
SISKS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y18930 Genomic DNA Translation: CAB57534.1 AE006641 Genomic DNA Translation: AAK41066.1 |
PIRi | C90226 |
RefSeqi | WP_009991358.1, NC_002754.1 |
Genome annotation databases
EnsemblBacteriai | AAK41066; AAK41066; SSO0769 |
GeneIDi | 44129774 |
KEGGi | sso:SSO0769 |
PATRICi | fig|273057.12.peg.768 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y18930 Genomic DNA Translation: CAB57534.1 AE006641 Genomic DNA Translation: AAK41066.1 |
PIRi | C90226 |
RefSeqi | WP_009991358.1, NC_002754.1 |
3D structure databases
SMRi | Q9UXF6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 273057.SSO0769 |
Genome annotation databases
EnsemblBacteriai | AAK41066; AAK41066; SSO0769 |
GeneIDi | 44129774 |
KEGGi | sso:SSO0769 |
PATRICi | fig|273057.12.peg.768 |
Phylogenomic databases
eggNOGi | arCOG00470, Archaea |
HOGENOMi | CLU_027255_1_1_2 |
InParanoidi | Q9UXF6 |
OMAi | GGWTRYG |
PhylomeDBi | Q9UXF6 |
Enzyme and pathway databases
BRENDAi | 3.6.4.B8, 6163 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
HAMAPi | MF_01508, RfcL, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003959, ATPase_AAA_core IPR027417, P-loop_NTPase IPR023935, Rep_factor-C_lsu |
Pfami | View protein in Pfam PF00004, AAA, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RFCL_SACS2 | |
Accessioni | Q9UXF6Primary (citable) accession number: Q9UXF6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 16, 2004 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families