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Protein

Exosome complex component Rrp41

Gene

rrp41

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails. Binds RNA.UniRule annotation3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Exosome complex component Rrp41UniRule annotation (EC:3.1.13.-UniRule annotation)
Gene namesi
Name:rrp41UniRule annotation
Ordered Locus Names:SSO0735
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Exosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi98R → E: Abolishes exoribonuclease activity; when associated with E-99. 1 Publication1
Mutagenesisi99R → E: Abolishes exoribonuclease activity; when associated with E-98. 1 Publication1
Mutagenesisi182D → A: Abolishes both exoribonuclease and polyadenylation activities. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001399911 – 248Exosome complex component Rrp41Add BLAST248

Interactioni

Subunit structurei

Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.UniRule annotation6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
rrp42Q9UXC03EBI-7981302,EBI-9009550

Protein-protein interaction databases

DIPiDIP-58154N
IntActiQ9UXC2, 2 interactors
MINTiQ9UXC2
STRINGi273057.SSO0735

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UXC2
SMRiQ9UXC2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UXC2

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase PH family. Rrp41 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01575 Archaea
COG0689 LUCA
HOGENOMiHOG000229515
InParanoidiQ9UXC2
KOiK11600
OMAiKGKGQGW
OrthoDBiPOG093Z0A4O

Family and domain databases

CDDicd11366 RNase_PH_archRRP41, 1 hit
Gene3Di3.30.230.70, 1 hit
HAMAPiMF_00591 Exosome_Rrp41, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR027408 PNPase/RNase_PH_dom_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR011807 Rrp41
PfamiView protein in Pfam
PF01138 RNase_PH, 1 hit
PF03725 RNase_PH_C, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55666 SSF55666, 1 hit
TIGRFAMsiTIGR02065 ECX1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UXC2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MREMLQVERP KLILDDGKRT DGRKPDELRS IKIELGVLKN ADGSAIFEMG
60 70 80 90 100
NTKAIAAVYG PKEMHPRHLS LPDRAVLRVR YHMTPFSTDE RKNPAPSRRE
110 120 130 140 150
IELSKVIREA LESAVLVELF PRTAIDVFTE ILQADAGSRL VSLMAASLAL
160 170 180 190 200
ADAGIPMRDL IAGVAVGKAD GVIILDLNET EDMWGEADMP IAMMPSLNQV
210 220 230 240
TLFQLNGSMT PDEFRQAFDL AVKGINIIYN LEREALKSKY VEFKEEGV
Length:248
Mass (Da):27,578
Last modified:May 1, 2000 - v1
Checksum:iEAB2C2C89DD5854C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18930 Genomic DNA Translation: CAB57569.1
AE006641 Genomic DNA Translation: AAK41031.1
PIRiH90221

Genome annotation databases

EnsemblBacteriaiAAK41031; AAK41031; SSO0735
KEGGisso:SSO0735
PATRICifig|273057.12.peg.731

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18930 Genomic DNA Translation: CAB57569.1
AE006641 Genomic DNA Translation: AAK41031.1
PIRiH90221

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BR2X-ray2.80B/D/F/H/J/L/N/P/R/T/V/X1-248[»]
2C37X-ray2.80B/D/F/H/J/L/N/P/R/T/V/X1-248[»]
2C38X-ray3.10B/D/F/H/J/L/N/P/R/T/V/X1-248[»]
2C39X-ray3.30B/D/F/H/J/L/N/P/R/T/V/X1-248[»]
2JE6X-ray1.60B1-248[»]
2JEAX-ray2.33B1-248[»]
2JEBX-ray2.40B1-248[»]
3L7ZX-ray2.41B/E/H4-248[»]
4BA1X-ray1.80B1-248[»]
4BA2X-ray2.50B1-248[»]
ProteinModelPortaliQ9UXC2
SMRiQ9UXC2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-58154N
IntActiQ9UXC2, 2 interactors
MINTiQ9UXC2
STRINGi273057.SSO0735

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK41031; AAK41031; SSO0735
KEGGisso:SSO0735
PATRICifig|273057.12.peg.731

Phylogenomic databases

eggNOGiarCOG01575 Archaea
COG0689 LUCA
HOGENOMiHOG000229515
InParanoidiQ9UXC2
KOiK11600
OMAiKGKGQGW
OrthoDBiPOG093Z0A4O

Miscellaneous databases

EvolutionaryTraceiQ9UXC2

Family and domain databases

CDDicd11366 RNase_PH_archRRP41, 1 hit
Gene3Di3.30.230.70, 1 hit
HAMAPiMF_00591 Exosome_Rrp41, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR027408 PNPase/RNase_PH_dom_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR011807 Rrp41
PfamiView protein in Pfam
PF01138 RNase_PH, 1 hit
PF03725 RNase_PH_C, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55666 SSF55666, 1 hit
TIGRFAMsiTIGR02065 ECX1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRRP41_SULSO
AccessioniPrimary (citable) accession number: Q9UXC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: May 1, 2000
Last modified: October 10, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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