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Protein

Exosome complex component Rrp42

Gene

rrp42

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.UniRule annotation2 Publications

GO - Molecular functioni

  • AU-rich element binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Exosome complex component Rrp42UniRule annotation
Gene namesi
Name:rrp42UniRule annotation
Ordered Locus Names:SSO0732
ORF Names:C20_023
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Exosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi112R → E: Abolishes exoribonuclease activity of the complex; when associated with E-116. 1 Publication1
Mutagenesisi116R → E: Abolishes exoribonuclease activity of the complex; when associated with E-112. 1 Publication1
Mutagenesisi218E → A: Does not change activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001400061 – 275Exosome complex component Rrp42Add BLAST275

Interactioni

Subunit structurei

Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.UniRule annotation6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
rrp41Q9UXC23EBI-9009550,EBI-7981302

Protein-protein interaction databases

DIPiDIP-60492N
IntActiQ9UXC0, 1 interactor
STRINGi273057.SSO0732

Structurei

Secondary structure

1275
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UXC0
SMRiQ9UXC0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UXC0

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase PH family. Rrp42 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01574 Archaea
COG2123 LUCA
HOGENOMiHOG000229504
InParanoidiQ9UXC0
KOiK12589
OMAiNPYDCTR
OrthoDBiPOG093Z075P

Family and domain databases

CDDicd11365 RNase_PH_archRRP42, 1 hit
Gene3Di3.30.230.70, 1 hit
HAMAPiMF_00622 Exosome_Rrp42, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR027408 PNPase/RNase_PH_dom_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR020869 Rrp42_archaea
PfamiView protein in Pfam
PF01138 RNase_PH, 1 hit
PF03725 RNase_PH_C, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55666 SSF55666, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UXC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSTPSNQNI IPIIKKESIV SLFEKGIRQD GRKLTDYRPL SITLDYAKKA
60 70 80 90 100
DGSALVKLGT TMVLAGTKLE IDKPYEDTPN QGNLIVNVEL LPLAYETFEP
110 120 130 140 150
GPPDENAIEL ARVVDRSLRD SKALDLTKLV IEPGKSVWTV WLDVYVLDYG
160 170 180 190 200
GNVLDACTLA SVAALYNTKV YKVEQHSNGI SVNKNEVVGK LPLNYPVVTI
210 220 230 240 250
SVAKVDKYLV VDPDLDEESI MDAKISFSYT PDLKIVGIQK SGKGSMSLQD
260 270
IDQAENTARS TAVKLLEELK KHLGI
Length:275
Mass (Da):30,194
Last modified:May 1, 2000 - v1
Checksum:i4188C9D6928A144C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18930 Genomic DNA Translation: CAB57571.1
AE006641 Genomic DNA Translation: AAK41030.1
PIRiG90221
RefSeqiWP_009991305.1, NC_002754.1

Genome annotation databases

EnsemblBacteriaiAAK41030; AAK41030; SSO0732
GeneIDi27427054
KEGGisso:SSO0732
PATRICifig|273057.12.peg.730

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18930 Genomic DNA Translation: CAB57571.1
AE006641 Genomic DNA Translation: AAK41030.1
PIRiG90221
RefSeqiWP_009991305.1, NC_002754.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BR2X-ray2.80A/C/E/G/I/K/M/O/Q/S/U/W1-275[»]
2C37X-ray2.80A/C/E/G/I/K/M/O/Q/S/U/W1-275[»]
2C38X-ray3.10A/C/E/G/I/K/M/O/Q/S/U/W1-275[»]
2C39X-ray3.30A/C/E/G/I/K/M/O/Q/S/U/W1-275[»]
2JE6X-ray1.60A1-275[»]
2JEAX-ray2.33A1-275[»]
2JEBX-ray2.40A1-275[»]
3L7ZX-ray2.41A/D/G1-275[»]
4BA1X-ray1.80A1-275[»]
4BA2X-ray2.50A1-275[»]
ProteinModelPortaliQ9UXC0
SMRiQ9UXC0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60492N
IntActiQ9UXC0, 1 interactor
STRINGi273057.SSO0732

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK41030; AAK41030; SSO0732
GeneIDi27427054
KEGGisso:SSO0732
PATRICifig|273057.12.peg.730

Phylogenomic databases

eggNOGiarCOG01574 Archaea
COG2123 LUCA
HOGENOMiHOG000229504
InParanoidiQ9UXC0
KOiK12589
OMAiNPYDCTR
OrthoDBiPOG093Z075P

Miscellaneous databases

EvolutionaryTraceiQ9UXC0

Family and domain databases

CDDicd11365 RNase_PH_archRRP42, 1 hit
Gene3Di3.30.230.70, 1 hit
HAMAPiMF_00622 Exosome_Rrp42, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR027408 PNPase/RNase_PH_dom_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR020869 Rrp42_archaea
PfamiView protein in Pfam
PF01138 RNase_PH, 1 hit
PF03725 RNase_PH_C, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55666 SSF55666, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRRP42_SULSO
AccessioniPrimary (citable) accession number: Q9UXC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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