Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Argininosuccinate synthase

Gene

argG

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei84CitrullineUniRule annotation1
Binding sitei114ATP; via amide nitrogenUniRule annotation1
Binding sitei116AspartateUniRule annotation1
Binding sitei120AspartateUniRule annotation1
Binding sitei120CitrullineUniRule annotation1
Binding sitei121AspartateUniRule annotation1
Binding sitei124CitrullineUniRule annotation1
Binding sitei171CitrullineUniRule annotation1
Binding sitei180CitrullineUniRule annotation1
Binding sitei253CitrullineUniRule annotation1
Binding sitei265CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 14ATPUniRule annotation9

GO - Molecular functioni

  • argininosuccinate synthase activity Source: GO_Central
  • ATP binding Source: UniProtKB-UniRule

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:SSO0638
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001486861 – 391Argininosuccinate synthaseAdd BLAST391

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi273057.SSO0638

Structurei

3D structure databases

ProteinModelPortaliQ9UX31
SMRiQ9UX31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00112 Archaea
COG0137 LUCA
HOGENOMiHOG000230093
InParanoidiQ9UX31
KOiK01940
OMAiPAREWGM
OrthoDBiPOG093Z02NI

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UX31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIVLAYSGG LDTTVSIRWL KETFKAEIIT VTVDVGQKDD FKKIEERAYI
60 70 80 90 100
AGASKHYTID AVRQFANNYI AYAIKLNGLY EGVYPLSTAL ARPLIAEKVV
110 120 130 140 150
EVAKKEGAEA VAHGSTSKGN DQVRFDLAVK ALYPDVKIIA PARIWNMTRE
160 170 180 190 200
DEIKYAKEKG IPIKVESDKY SIDENLWGRS IEGDIISDPS LEVPEDAFEW
210 220 230 240 250
TKQIYNKKEI VSIEFSNGVP TAVNGEKMEL NKLVDFLNLK FGSHGFGRVE
260 270 280 290 300
HIENRVVGFK SREVYEVPAA LGLIYAHIDL EKTIYTPMEL RFKRHIDQLW
310 320 330 340 350
SDLVYQGLWF EPLRETLHKV ADEMNKWISG EAKVEVSNGS FRIVGRESEY
360 370 380 390
SPYSEKIASY NKGWYPSDEM ARGFIEIWGM HSLIARRVRG L
Length:391
Mass (Da):44,487
Last modified:September 27, 2005 - v2
Checksum:i58565E5F25A4F5FC
GO

Sequence cautioni

The sequence AAK40946 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB57663 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18930 Genomic DNA Translation: CAB57663.1 Different initiation.
AE006641 Genomic DNA Translation: AAK40946.1 Different initiation.
PIRiC90211
RefSeqiWP_009991175.1, NC_002754.1

Genome annotation databases

EnsemblBacteriaiAAK40946; AAK40946; SSO0638
GeneIDi27426940
KEGGisso:SSO0638
PATRICifig|273057.12.peg.643

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18930 Genomic DNA Translation: CAB57663.1 Different initiation.
AE006641 Genomic DNA Translation: AAK40946.1 Different initiation.
PIRiC90211
RefSeqiWP_009991175.1, NC_002754.1

3D structure databases

ProteinModelPortaliQ9UX31
SMRiQ9UX31
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0638

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40946; AAK40946; SSO0638
GeneIDi27426940
KEGGisso:SSO0638
PATRICifig|273057.12.peg.643

Phylogenomic databases

eggNOGiarCOG00112 Archaea
COG0137 LUCA
HOGENOMiHOG000230093
InParanoidiQ9UX31
KOiK01940
OMAiPAREWGM
OrthoDBiPOG093Z02NI

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00113

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASSY_SULSO
AccessioniPrimary (citable) accession number: Q9UX31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: September 27, 2005
Last modified: November 7, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again