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UniProtKB - Q9UX16 (TYW3_SACS2)
Protein
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase
Gene
taw3
Organism
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Status
Functioni
S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.
UniRule annotationCatalytic activityi
- 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine37 in tRNAPhe + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine37 in tRNAPhe + H+ + S-adenosyl-L-homocysteineUniRule annotationEC:2.1.1.282UniRule annotation
GO - Molecular functioni
- tRNA methyltransferase activity Source: GO_Central
GO - Biological processi
- tRNA methylation Source: GO_Central
- wybutosine biosynthetic process Source: InterPro
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | tRNA processing |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferaseUniRule annotation (EC:2.1.1.282UniRule annotation)Alternative name(s): tRNA wyosine derivatives biosynthesis protein Taw3UniRule annotation |
Gene namesi | Name:taw3UniRule annotation Ordered Locus Names:SSO0622 ORF Names:C08_028 |
Organismi | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) |
Taxonomic identifieri | 273057 [NCBI] |
Taxonomic lineagei | Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Saccharolobus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000157102 | 1 – 209 | tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferaseAdd BLAST | 209 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9UX16 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UX16 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TYW3 family.UniRule annotation
Phylogenomic databases
eggNOGi | arCOG04156, Archaea |
HOGENOMi | CLU_047426_2_1_2 |
InParanoidi | Q9UX16 |
OMAi | GKWHHYA |
PhylomeDBi | Q9UX16 |
Family and domain databases
Gene3Di | 3.30.1960.10, 1 hit |
HAMAPi | MF_00266, TYW3_archaea, 1 hit |
InterProi | View protein in InterPro IPR022908, Taw3 IPR003827, tRNA_yW-synthesising IPR036602, tRNA_yW-synthesising-like_sf |
Pfami | View protein in Pfam PF02676, TYW3, 1 hit |
SUPFAMi | SSF111278, SSF111278, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9UX16-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLVWEELREK ALNKIYHDKE IGYLDPDILG FLLAFYRNRN DVYTQSSCSG
60 70 80 90 100
RITIVDAEMP WDRKNSTIIF KNHLRITEQD LEDVLSKNQV RRLWLIVQGP
110 120 130 140 150
IIHIYAKNIE TGWDILKIAR EAGFKHSGIL ATNQKGVLVE LRTGIRMVHL
160 170 180 190 200
LRESNTERVD KDKIKTLVNV CNEVLARGKQ KMNLLKDLLS SSSNNSMELG
KNSKLKTPI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y18930 Genomic DNA Translation: CAB57678.1 AE006641 Genomic DNA Translation: AAK40933.1 |
PIRi | F90209 |
RefSeqi | WP_009991156.1, NC_002754.1 |
Genome annotation databases
EnsemblBacteriai | AAK40933; AAK40933; SSO0622 |
GeneIDi | 44129624 |
KEGGi | sso:SSO0622 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y18930 Genomic DNA Translation: CAB57678.1 AE006641 Genomic DNA Translation: AAK40933.1 |
PIRi | F90209 |
RefSeqi | WP_009991156.1, NC_002754.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1TLJ | X-ray | 2.80 | A/B | 1-209 | [»] | |
SMRi | Q9UX16 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 273057.SSO0622 |
Genome annotation databases
EnsemblBacteriai | AAK40933; AAK40933; SSO0622 |
GeneIDi | 44129624 |
KEGGi | sso:SSO0622 |
Phylogenomic databases
eggNOGi | arCOG04156, Archaea |
HOGENOMi | CLU_047426_2_1_2 |
InParanoidi | Q9UX16 |
OMAi | GKWHHYA |
PhylomeDBi | Q9UX16 |
Miscellaneous databases
EvolutionaryTracei | Q9UX16 |
Family and domain databases
Gene3Di | 3.30.1960.10, 1 hit |
HAMAPi | MF_00266, TYW3_archaea, 1 hit |
InterProi | View protein in InterPro IPR022908, Taw3 IPR003827, tRNA_yW-synthesising IPR036602, tRNA_yW-synthesising-like_sf |
Pfami | View protein in Pfam PF02676, TYW3, 1 hit |
SUPFAMi | SSF111278, SSF111278, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TYW3_SACS2 | |
Accessioni | Q9UX16Primary (citable) accession number: Q9UX16 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families