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Protein

DNA polymerase sliding clamp

Gene

pcn

Organism
Thermococcus fumicolans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase sliding clampUniRule annotation
Alternative name(s):
Proliferating cell nuclear antigen homologUniRule annotation
Short name:
PCNAUniRule annotation
Tfu PCNA
Gene namesi
Name:pcnUniRule annotation
Synonyms:pcnA
OrganismiThermococcus fumicolans
Taxonomic identifieri46540 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492211 – 249DNA polymerase sliding clampAdd BLAST249

Interactioni

Subunit structurei

Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9UWR9
SMRiQ9UWR9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UWR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFEIVFDGA KEFADLIATA SNLIDEAAFK VTDEGISMRA MDPSRVVLID
60 70 80 90 100
LNLPESIFSK YEVEEEETIG INMDHFKKIL KRGKGKDTLI LKKGDENFLE
110 120 130 140 150
ITFEGTAKRT FRLPLIDVEE LELDLPELPF TAKVVLLGEV LKEAVKDASL
160 170 180 190 200
VSDAMKFIAK ENEFSMRAEG ETNEVEIKLT LEDEGLLDIE VEEETKSAYG
210 220 230 240
ISYLADMVKG IGKADEVTIR FGNEMPLQMD YFIRDEGKLT FLLAPRVED
Length:249
Mass (Da):28,043
Last modified:May 1, 2000 - v1
Checksum:i3DE42911966EFCE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ130939 Genomic DNA Translation: CAB59006.1

Similar proteinsi

Entry informationi

Entry nameiPCNA_THEFM
AccessioniPrimary (citable) accession number: Q9UWR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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