UniProtKB - Q9UW98 (DPP5_TRIRU)
Protein
Dipeptidyl-peptidase 5
Gene
DPPV
Organism
Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
Status
Functioni
Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini. Contributes to pathogenicity (By similarity).By similarity1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 558 | Charge relay systemBy similarity | 1 | |
Active sitei | 641 | Charge relay systemBy similarity | 1 | |
Active sitei | 673 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- aminopeptidase activity Source: UniProtKB-KW
- serine-type peptidase activity Source: UniProtKB-KW
GO - Biological processi
- pathogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | Aminopeptidase, Hydrolase, Protease, Serine protease |
Biological process | Virulence |
Protein family/group databases
ESTHERi | triru-DPPV, Prolyl_oligopeptidase_S9 |
MEROPSi | S09.012 |
Names & Taxonomyi
Protein namesi | Recommended name: Dipeptidyl-peptidase 5 (EC:3.4.14.-)Alternative name(s): Dipeptidyl-peptidase V Short name: DPP V Short name: DppV Allergen: Tri r 4 |
Gene namesi | Name:DPPV |
Organismi | Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum) |
Taxonomic identifieri | 5551 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › Arthrodermataceae › Trichophyton |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Allergenic propertiesi
Causes an allergic reaction in human. Binds to IgE and associated with delayed type hypersensitivity.
Keywords - Diseasei
AllergenProtein family/group databases
Allergomei | 3506, Tri r 4.0101 653, Tri r 4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000027225 | 20 – 726 | Dipeptidyl-peptidase 5Add BLAST | 707 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 96 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 252 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 485 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 605 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 699 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PRIDEi | Q9UW98 |
Expressioni
Inductioni
Expression is strongly increased during growth on protein-rich medium containing keratin.1 Publication
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase S9C family.Curated
Keywords - Domaini
SignalFamily and domain databases
Gene3Di | 2.120.10.30, 1 hit 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR029058, AB_hydrolase IPR011659, PD40 IPR001375, Peptidase_S9 |
Pfami | View protein in Pfam PF07676, PD40, 1 hit PF00326, Peptidase_S9, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9UW98-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAKWLIAS LAFASSGLAF TPEDFISAPR RGEAIPDPKG ELAVFHVSKY
60 70 80 90 100
NFDKKDRPSG WNLLNLKNGD INVLTTDSDV SEITWLGDGT KVVYINGTDS
110 120 130 140 150
VKGGVGIWIS DAKNFGNAYK AGSVNGAFSG LKLAKSGDKI NFVGYGQSTT
160 170 180 190 200
KGDLYNEAAA KEAVSSARIY DSLFVRHWDT YVGTQFNAVF SGTLTKSGDK
210 220 230 240 250
YSFDGKLKNL VQPVKYAESP YPPFGGSGDY DLSSDGKTVA FMSKAPELPK
260 270 280 290 300
ANLTTSYIFL VPHDGSRVAE PINKRNGPRT PQGIEGASSS PVFSPDGKRI
310 320 330 340 350
AYLQMAAKNY ESDRRVIHIA EVGTNKPVQR IASNWDRSPE AVKWSSDGRT
360 370 380 390 400
LYVTAEDHAT GKLFTLPADA RDNHKPAVVK HDGSVSSFYF IGSSKSVLIS
410 420 430 440 450
GNSLWSNALY QVATPDRPNR KLFYANEHDP ELKGLGPNDI EPLWVDGART
460 470 480 490 500
KIHSWIVKPT GFDKNKVYPL AFLIHGGPQG SWGDNWSTRW NPRVWADQGY
510 520 530 540 550
VVVAPNPTGS TGFGQKLTDD ITNDWGGAPY KDLVKIWEHV HDHIKYIDTD
560 570 580 590 600
NGIAAGASFG GFMVNWIQGQ DLGRKFKALV SHDGTFVGSS KIGTDELFFI
610 620 630 640 650
EHDFNGTFFE ARQNYDRWDC SKPELVAKWS TPQLVVHNDF DFRLSVAEGV
660 670 680 690 700
GLFNVLQEKG VPSRFLNFPD ETHWVTKPEN SLVWHQQVLG WVNKWSGINK
710 720
SNPKSIKLSD CPIEVVDHEA HSYFDY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF082514 mRNA Translation: AAD52012.1 AY525331 Genomic DNA Translation: AAS19461.1 AF407232 Genomic DNA Translation: AAN03632.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF082514 mRNA Translation: AAD52012.1 AY525331 Genomic DNA Translation: AAS19461.1 AF407232 Genomic DNA Translation: AAN03632.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
Allergomei | 3506, Tri r 4.0101 653, Tri r 4 |
ESTHERi | triru-DPPV, Prolyl_oligopeptidase_S9 |
MEROPSi | S09.012 |
Proteomic databases
PRIDEi | Q9UW98 |
Family and domain databases
Gene3Di | 2.120.10.30, 1 hit 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR029058, AB_hydrolase IPR011659, PD40 IPR001375, Peptidase_S9 |
Pfami | View protein in Pfam PF07676, PD40, 1 hit PF00326, Peptidase_S9, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DPP5_TRIRU | |
Accessioni | Q9UW98Primary (citable) accession number: Q9UW98 Secondary accession number(s): Q6E7G5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 16, 2004 |
Last sequence update: | May 1, 2000 | |
Last modified: | August 12, 2020 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Documents
- Allergens
Nomenclature of allergens and list of entries - Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families