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Protein

Serine/threonine-protein phosphatase PP1

Gene

pph-3

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Manganese 1By similarity1
Metal bindingi66Manganese 1By similarity1
Metal bindingi92Manganese 1By similarity1
Metal bindingi92Manganese 2By similarity1
Metal bindingi124Manganese 2By similarity1
Active sitei125Proton donorBy similarity1
Metal bindingi173Manganese 2By similarity1
Metal bindingi248Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1 (EC:3.1.3.16)
Alternative name(s):
Phosphoprotein phosphatase 1
Gene namesi
Name:pph-3
Synonyms:ppp-1
ORF Names:NCU00043
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 3, Linkage Group III

Organism-specific databases

EuPathDBiFungiDB:NCU00043

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588171 – 308Serine/threonine-protein phosphatase PP1Add BLAST308

Proteomic databases

PRIDEiQ9UW86

Structurei

3D structure databases

ProteinModelPortaliQ9UW86
SMRiQ9UW86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000172697
InParanoidiQ9UW86
KOiK06269
OrthoDBiEOG092C37EX

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR037981 PPP1CC
IPR006186 Ser/Thr-sp_prot-phosphatase
IPR031675 STPPase_N
PANTHERiPTHR11668:SF204 PTHR11668:SF204, 1 hit
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF16891 STPPase_N, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UW86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADHTEVDLD SIIDRLLEVR GSRPGKQVQL LEAEIRYLCT KAREIFISQP
60 70 80 90 100
ILLELEAPIK ICGDIHGQYY DLLRLFEYGG FPPEANYLFL GDYVDRGKQS
110 120 130 140 150
LETICLLLAY KIKYPENFFI LRGNHECASI NRIYGFYDEC KRRYNIKLWK
160 170 180 190 200
TFTDCFNCLP IAAIIDEKIF TMHGGLSPDL NSMEQIRRVM RPTDIPDCGL
210 220 230 240 250
LCDLLWSDPD KDITGWSEND RGVSFTFGPD VVSRFLQKHD MDLICRAHQV
260 270 280 290 300
VEDGYEFFSK RQLVTLFSAP NYCGEFDNAG AMMSVDESLL CSFQILKPAE

KKQKFGRR
Length:308
Mass (Da):35,568
Last modified:May 1, 2000 - v1
Checksum:i333A728F20860AB1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154D → E in AAC05275 (PubMed:12524044).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049853 mRNA Translation: AAC05275.1
AF124149 Genomic DNA Translation: AAD47567.1
CM002238 Genomic DNA Translation: EAA26918.2
RefSeqiXP_956154.2, XM_951061.3

Genome annotation databases

EnsemblFungiiEAA26918; EAA26918; NCU00043
GeneIDi3872306
KEGGincr:NCU00043

Similar proteinsi

Entry informationi

Entry nameiPP1_NEUCR
AccessioniPrimary (citable) accession number: Q9UW86
Secondary accession number(s): O59927, Q7RV51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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