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UniProtKB - Q9UW02 (THIO_COPCM)
Protein
Thioredoxin
Gene
N/A
Organism
Coprinus comatus (Shaggy mane)
Status
Functioni
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 24 | Deprotonates C-terminal active site CysBy similarity | 1 | |
Active sitei | 30 | NucleophileBy similarity | 1 | |
Sitei | 31 | Contributes to redox potential valueBy similarity | 1 | |
Sitei | 32 | Contributes to redox potential valueBy similarity | 1 | |
Active sitei | 33 | NucleophileBy similarity | 1 |
GO - Molecular functioni
- protein-disulfide reductase activity Source: InterPro
Keywordsi
Biological process | Electron transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: ThioredoxinShort name: Trx Alternative name(s): Allergen: Cop c 2 |
Organismi | Coprinus comatus (Shaggy mane) |
Taxonomic identifieri | 56187 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Agaricomycetes › Agaricomycetidae › Agaricales › Agaricaceae › Coprinus |
Pathology & Biotechi
Allergenic propertiesi
Causes an allergic reaction in human.
Keywords - Diseasei
AllergenProtein family/group databases
Allergomei | 226, Cop c 2 3210, Cop c 2.0101 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000120038 | 1 – 106 | ThioredoxinAdd BLAST | 106 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 30 ↔ 33 | Redox-activePROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 106 | ThioredoxinPROSITE-ProRule annotationAdd BLAST | 105 |
Sequence similaritiesi
Belongs to the thioredoxin family.Curated
Keywords - Domaini
Redox-active centerFamily and domain databases
InterProi | View protein in InterPro IPR005746, Thioredoxin IPR036249, Thioredoxin-like_sf IPR017937, Thioredoxin_CS IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF00085, Thioredoxin, 1 hit |
PIRSFi | PIRSF000077, Thioredoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR01068, thioredoxin, 1 hit |
PROSITEi | View protein in PROSITE PS00194, THIOREDOXIN_1, 1 hit PS51352, THIOREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9UW02-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVQVISNLDE FNKLTNSGKI IIIDFWATWC GPCRVISPIF EKFSEKYGAN
60 70 80 90 100
NIVFAKVDVD TASDISEEAK IRAMPTFQVY KDGQKIDELV GANPTALESL
VQKSLA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ242791 mRNA Translation: CAB52130.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ242791 mRNA Translation: CAB52130.1 |
3D structure databases
AlphaFoldDBi | Q9UW02 |
SMRi | Q9UW02 |
ModBasei | Search... |
Protein family/group databases
Allergomei | 226, Cop c 2 3210, Cop c 2.0101 |
Family and domain databases
InterProi | View protein in InterPro IPR005746, Thioredoxin IPR036249, Thioredoxin-like_sf IPR017937, Thioredoxin_CS IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF00085, Thioredoxin, 1 hit |
PIRSFi | PIRSF000077, Thioredoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR01068, thioredoxin, 1 hit |
PROSITEi | View protein in PROSITE PS00194, THIOREDOXIN_1, 1 hit PS51352, THIOREDOXIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | THIO_COPCM | |
Accessioni | Q9UW02Primary (citable) accession number: Q9UW02 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Documents
- Allergens
Nomenclature of allergens and list of entries - SIMILARITY comments
Index of protein domains and families