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Protein

Alpha-galactosidase

Gene

MEL

Organism
Torulaspora delbrueckii (Yeast) (Candida colliculosa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73SubstrateBy similarity1
Binding sitei74SubstrateBy similarity1
Binding sitei148SubstrateBy similarity1
Active sitei150NucleophileBy similarity1
Binding sitei206SubstrateBy similarity1
Active sitei210Proton donorBy similarity1
Binding sitei252SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH27 Glycoside Hydrolase Family 27
mycoCLAPiMEL27A_TORDE

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-galactosidase (EC:3.2.1.22)
Alternative name(s):
Alpha-D-galactoside galactohydrolase
MELt
Melibiase
Gene namesi
Name:MEL
OrganismiTorulaspora delbrueckii (Yeast) (Candida colliculosa)
Taxonomic identifieri4950 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeTorulaspora

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000101023 – 474Alpha-galactosidaseAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 75By similarity
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi122 ↔ 152By similarity
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi222 ↔ 238By similarity
Disulfide bondi224 ↔ 231By similarity
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi414N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi423N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi436N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi455N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9UVD6
SMRiQ9UVD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 27 family.Curated

Keywords - Domaini

Signal

Family and domain databases

CDDicd14792 GH27, 1 hit
Gene3Di2.60.40.1180, 1 hit
3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR002241 Glyco_hydro_27
IPR000111 Glyco_hydro_27/36_CS
IPR013780 Glyco_hydro_b
IPR006215 Glyco_hydro_melibiase
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR11452 PTHR11452, 1 hit
PfamiView protein in Pfam
PF16499 Melibiase_2, 1 hit
PRINTSiPR00740 GLHYDRLASE27
PR00748 MELIBIASE
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00512 ALPHA_GALACTOSIDASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UVD6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MINFSLLTSI VLLASKVVGV SPSYNGLGLT PQMGWNNWNT FACNVSEDLL
60 70 80 90 100
LSTVDRIAAL GLRDIGYHYV ILDDCWSDGR DSDGMLVPDS TKFPNGMKHV
110 120 130 140 150
ADYLHGKDFL FGMYSSAGEY TCAGYAGSLD HEEDDAAFFA KNEVDYLKYD
160 170 180 190 200
NCYNRGQFGT PETSFNRYRA MSEALNKTER PIFYSLCNWG QDLTFYWGSG
210 220 230 240 250
IANSWRISGD ITAEFDRPDS RCPCDGDEYD CPYAGFHCSI MNILNKAAPM
260 270 280 290 300
GQNAGVGGWN DLDCLEVGVG NLTDDEEKAH FSMWAIVKSA MVIGADVRNL
310 320 330 340 350
KPSSFSIYSQ ASVLAINQDP AGAPAIRVWR RYVPETDQHG QGEVQLWSGP
360 370 380 390 400
LDNGDRVVAL LNGGAKERPM VAYLEDIFID SFVGSEELSS TWNVYDLWAN
410 420 430 440 450
RIDDSTASQI LVGNRTANGL LYNATQLSYA DGLKANDTRL FGEKVGTIEP
460 470
YGLLNVTVPA HGVGLFRLRR ESRK
Length:474
Mass (Da):52,364
Last modified:May 1, 2000 - v1
Checksum:i6F058455B3A3D7B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027130 Genomic DNA Translation: BAA86883.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027130 Genomic DNA Translation: BAA86883.1

3D structure databases

ProteinModelPortaliQ9UVD6
SMRiQ9UVD6
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH27 Glycoside Hydrolase Family 27
mycoCLAPiMEL27A_TORDE

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd14792 GH27, 1 hit
Gene3Di2.60.40.1180, 1 hit
3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR002241 Glyco_hydro_27
IPR000111 Glyco_hydro_27/36_CS
IPR013780 Glyco_hydro_b
IPR006215 Glyco_hydro_melibiase
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR11452 PTHR11452, 1 hit
PfamiView protein in Pfam
PF16499 Melibiase_2, 1 hit
PRINTSiPR00740 GLHYDRLASE27
PR00748 MELIBIASE
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00512 ALPHA_GALACTOSIDASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMEL_TORDE
AccessioniPrimary (citable) accession number: Q9UVD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: May 1, 2000
Last modified: October 10, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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