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UniProtKB - Q9UUN9 (ALD2_SPOSA)
Protein
Aldehyde reductase 2
Gene
N/A
Organism
Sporidiobolus salmonicolor (Sporobolomyces salmonicolor)
Status
Functioni
Catalyzes the asymmetric reduction of o-substituted aliphatic and aromatic aldehydes and ketones to an S-enantiomer. Reduces ethyl 4-chloro-3-oxobutanoate to ethyl (S)-4-chloro-3-hydroxybutanoate.
2 PublicationsCatalytic activityi
- EC:1.1.1.22 Publications
Activity regulationi
Inhibited by quercetin and diphenylhydantoin.1 Publication
pH dependencei
Optimum pH is 5.5.
Temperature dependencei
Optimum temperature is 40 degrees Celsius.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 177 | NADPBy similarity | 1 |
GO - Molecular functioni
- alcohol dehydrogenase (NADP+) activity Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NADP |
Names & Taxonomyi
Protein namesi | Recommended name: Aldehyde reductase 2 (EC:1.1.1.2)Alternative name(s): Aldehyde reductase II Short name: ARII |
Organismi | Sporidiobolus salmonicolor (Sporobolomyces salmonicolor)Imported |
Taxonomic identifieri | 5005 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Basidiomycota › Pucciniomycotina › Microbotryomycetes › Sporidiobolales › Sporidiobolaceae › Sporidiobolus |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 19 | G → A: Results in loss of substrate inhibition and of NADPH-dependent reductase activity. 1 Publication | 1 | |
Mutagenesisi | 22 | G → A: Results in loss of substrate inhibition and of NADPH-dependent reductase activity. 1 Publication | 1 | |
Mutagenesisi | 25 | A → G: Only active when NADPH is replaced by NADH. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000215575 | 2 – 343 | Aldehyde reductase 2Add BLAST | 342 |
Interactioni
Subunit structurei
Monomer.
1 PublicationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9UUN9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UUN9 |
Family & Domainsi
Sequence similaritiesi
Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.Curated
Family and domain databases
InterProi | View protein in InterPro IPR001509, Epimerase_deHydtase IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01370, Epimerase, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9UUN9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKIDNAVLP EGSLVLVTGA NGFVASHVVE QLLEHGYKVR GTARSASKLA
60 70 80 90 100
NLQKRWDAKY PGRFETAVVE DMLKQGAYDE VIKGAAGVAH IASVVSFSNK
110 120 130 140 150
YDEVVTPAIG GTLNALRAAA ATPSVKRFVL TSSTVSALIP KPNVEGIYLD
160 170 180 190 200
EKSWNLESID KAKTLPESDP QKSLWVYAAS KTEAELAAWK FMDENKPHFT
210 220 230 240 250
LNAVLPNYTI GTIFDPETQS GSTSGWMMSL FNGEVSPALA LMPPQYYVSA
260 270 280 290 300
VDIGLLHLGC LVLPQIERRR VYGTAGTFDW NTVLATFRKL YPSKTFPADF
310 320 330 340
PDQGQDLSKF DTAPSLEILK SLGRPGWRSI EESIKDLVGS ETA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF160799 Genomic DNA Translation: AAF15999.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF160799 Genomic DNA Translation: AAF15999.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1UJM | X-ray | 2.00 | A/B | 2-343 | [»] | |
1Y1P | X-ray | 1.60 | A/B | 2-343 | [»] | |
1ZZE | X-ray | 1.80 | A/B | 2-343 | [»] | |
SMRi | Q9UUN9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UUN9 |
Family and domain databases
InterProi | View protein in InterPro IPR001509, Epimerase_deHydtase IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01370, Epimerase, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ALD2_SPOSA | |
Accessioni | Q9UUN9Primary (citable) accession number: Q9UUN9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 30, 2003 |
Last sequence update: | January 23, 2007 | |
Last modified: | June 2, 2021 | |
This is version 82 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families