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Protein

Ubiquitin carboxyl-terminal hydrolase 11

Gene

ubp11

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei59NucleophilePROSITE-ProRule annotation1
Active sitei302Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Protein family/group databases

MEROPSiC19.A63

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 11 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 11
Ubiquitin thioesterase 11
Ubiquitin-specific-processing protease 11
Gene namesi
Name:ubp11
ORF Names:SPBC19C2.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC19C2.04c
PomBaseiSPBC19C2.04c ubp11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806111 – 350Ubiquitin carboxyl-terminal hydrolase 11Add BLAST350

Proteomic databases

PaxDbiQ9UUD6
PRIDEiQ9UUD6

Interactioni

Protein-protein interaction databases

BioGridi277237, 23 interactors
STRINGi4896.SPBC19C2.04c.1

Structurei

3D structure databases

ProteinModelPortaliQ9UUD6
SMRiQ9UUD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 344USPAdd BLAST296

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

InParanoidiQ9UUD6
OrthoDBiEOG092C3LER
PhylomeDBiQ9UUD6

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR037798 UBP8
IPR018200 USP_CS
IPR028889 USP_dom
PANTHERiPTHR43961:SF2 PTHR43961:SF2, 1 hit
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UUD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTPLSISR AKKYKTVFKG AAILTTFAAL YIVTSPSTGK RLVKNASIKG
60 70 80 90 100
LYNVSGNDCF LNCVLQSLAS QESLLEILKL RCSSSTLYAT LYELLQKLNS
110 120 130 140 150
GPGNPITPGS FLNSLEIATN KKLVRSIQQD AQEFLQHLVE TLELQKPHTY
160 170 180 190 200
KWSKVLSFPV DSPFIGTMEQ KVQCCQCLAI SISYSTATSI QLCLPPEYSG
210 220 230 240 250
NSNVSLLSLM EADREQHISD YKCDSCFKSS PKHSKTSCIR TVDWKNPPTI
260 270 280 290 300
LQIQLERTSY TCQGLTRNNV SISFPSKLIL KNKHHYILRS LITHSGSVTY
310 320 330 340 350
GHYLCYRLQD DIWWKANDSL ITKSSLNEAL SQTRSACLLF YEMESPLALD
Length:350
Mass (Da):39,169
Last modified:May 1, 2000 - v1
Checksum:i53986D30F9552DA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB52031.1
PIRiT39795
RefSeqiNP_595689.1, NM_001021586.2

Genome annotation databases

EnsemblFungiiSPBC19C2.04c.1; SPBC19C2.04c.1:pep; SPBC19C2.04c
GeneIDi2540714
KEGGispo:SPBC19C2.04c

Similar proteinsi

Entry informationi

Entry nameiUBP11_SCHPO
AccessioniPrimary (citable) accession number: Q9UUD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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