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UniProtKB - Q9UTP9 (DBP4_SCHPO)
Protein
ATP-dependent RNA helicase dbp4
Gene
dbp4
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity).
By similarityCatalytic activityi
- EC:3.6.4.13
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 83 – 90 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: RHEA
- RNA binding Source: UniProtKB-KW
- RNA helicase activity Source: PomBase
GO - Biological processi
- rRNA processing Source: PomBase
Keywordsi
Molecular function | Helicase, Hydrolase, RNA-binding |
Biological process | Ribosome biogenesis, rRNA processing |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:dbp4 ORF Names:SPAC1093.05 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC1093.05 |
VEuPathDBi | FungiDB:SPAC1093.05 |
Subcellular locationi
Nucleus
- nucleolus By similarity
Cytosol
- cytosol Source: PomBase
Nucleus
Other locations
- cytoplasm Source: PomBase
- small-subunit processome Source: PomBase
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000232203 | 1 – 735 | ATP-dependent RNA helicase dbp4Add BLAST | 735 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 500 | Phosphoserine1 Publication | 1 | |
Modified residuei | 503 | Phosphoserine1 Publication | 1 | |
Modified residuei | 504 | Phosphoserine1 Publication | 1 | |
Modified residuei | 545 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q9UTP9 |
PaxDbi | Q9UTP9 |
PTM databases
iPTMneti | Q9UTP9 |
Interactioni
Subunit structurei
Interacts with the U3 and U14 snoRNAs. Associates with pre-ribosomal complexes (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 278126, 2 interactors |
STRINGi | 4896.SPAC1093.05.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 70 – 244 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 175 | |
Domaini | 270 – 424 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 155 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 483 – 513 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 652 – 712 | DisorderedSequence analysisAdd BLAST | 61 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 39 – 67 | Q motifAdd BLAST | 29 | |
Motifi | 192 – 195 | DEAD box | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 483 – 504 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 652 – 669 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 689 – 712 | Basic and acidic residuesSequence analysisAdd BLAST | 24 |
Domaini
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0343, Eukaryota |
HOGENOMi | CLU_003041_26_1_1 |
InParanoidi | Q9UTP9 |
OMAi | YDKMFER |
PhylomeDBi | Q9UTP9 |
Family and domain databases
Gene3Di | 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR011545, DEAD/DEAH_box_helicase_dom IPR025313, DUF4217 IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR000629, RNA-helicase_DEAD-box_CS IPR014014, RNA_helicase_DEAD_Q_motif |
Pfami | View protein in Pfam PF00270, DEAD, 1 hit PF13959, DUF4217, 1 hit PF00271, Helicase_C, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM01178, DUF4217, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00039, DEAD_ATP_HELICASE, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51195, Q_MOTIF, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9UTP9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPKNRTGRSR EAREKKRKEE EEEIEELNSQ IEALSETVDH FAELPLTQPT
60 70 80 90 100
KSALKNAHFI TLTEIQKQCI PSALKGRDIL GAAKTGSGKT LAFIVPLIEN
110 120 130 140 150
LYRKKWTSLD GLGALVISPT RELAIQTFET LVKIGRLHSF SAGLIIGGNN
160 170 180 190 200
YKEEKERLSR MNILVCTPGR LLQHIDQAVN FDTSGLQMLI LDEADRILDM
210 220 230 240 250
GFRTTLDAIV SSLPVHRQTM LFSATQTKSV KDLARLSLQN PDFISVHEND
260 270 280 290 300
TSSTPSNLNQ FYLTVPLTEK LDILFGFIRT HLKFKTIVFL SSCKQVRFVY
310 320 330 340 350
ETFRRMRPGI SLLHLHGKQK QTTRTEVTAK FTSSRHVVLF CTDIVARGLD
360 370 380 390 400
FPAVDWVIQL DAPEDVDTYI HRVGRTARYN RSGNALLLLL PSEEAFLKRL
410 420 430 440 450
ESKKIAVERI NVKDGKKTSI RNQLQNLCFK DNDIKYIGQK AFISYLRSIY
460 470 480 490 500
LQKDKDVFQL DKLPVEAFAD SLGLPGTPKI TFGKLKNHSQ SQKDYNSSTS
510 520 530 540 550
LDSSEESEVD VENKQNVRTK YDRIFERKNQ DVLAAHRQRL VEVNSDEDDG
560 570 580 590 600
DFLQVKRVDH DLPEETGERF NANSKRKEKM ASSKKAMLKY KKSADKVYFD
610 620 630 640 650
DEGNAIPFYA MNTEDTFQKA GDPAALIASH LAEERKALEK ADITDKETVR
660 670 680 690 700
QKQLEKKRRR QELERITQQD ATPDEYVPEG PIVAFVDDEL PETSKKQKKW
710 720 730
FEDNDERDHG GIVEVENLNS LEDQEALALK LMGAA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB60250.1 |
PIRi | T50068 |
RefSeqi | NP_594652.1, NM_001020081.2 |
Genome annotation databases
EnsemblFungii | SPAC1093.05.1; SPAC1093.05.1:pep; SPAC1093.05 |
GeneIDi | 2541630 |
KEGGi | spo:SPAC1093.05 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB60250.1 |
PIRi | T50068 |
RefSeqi | NP_594652.1, NM_001020081.2 |
3D structure databases
SMRi | Q9UTP9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 278126, 2 interactors |
STRINGi | 4896.SPAC1093.05.1 |
PTM databases
iPTMneti | Q9UTP9 |
Proteomic databases
MaxQBi | Q9UTP9 |
PaxDbi | Q9UTP9 |
Genome annotation databases
EnsemblFungii | SPAC1093.05.1; SPAC1093.05.1:pep; SPAC1093.05 |
GeneIDi | 2541630 |
KEGGi | spo:SPAC1093.05 |
Organism-specific databases
PomBasei | SPAC1093.05 |
VEuPathDBi | FungiDB:SPAC1093.05 |
Phylogenomic databases
eggNOGi | KOG0343, Eukaryota |
HOGENOMi | CLU_003041_26_1_1 |
InParanoidi | Q9UTP9 |
OMAi | YDKMFER |
PhylomeDBi | Q9UTP9 |
Miscellaneous databases
PROi | PR:Q9UTP9 |
Family and domain databases
Gene3Di | 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR011545, DEAD/DEAH_box_helicase_dom IPR025313, DUF4217 IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR000629, RNA-helicase_DEAD-box_CS IPR014014, RNA_helicase_DEAD_Q_motif |
Pfami | View protein in Pfam PF00270, DEAD, 1 hit PF13959, DUF4217, 1 hit PF00271, Helicase_C, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM01178, DUF4217, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00039, DEAD_ATP_HELICASE, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51195, Q_MOTIF, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DBP4_SCHPO | |
Accessioni | Q9UTP9Primary (citable) accession number: Q9UTP9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2006 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families