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Entry version 127 (07 Apr 2021)
Sequence version 2 (29 Mar 2004)
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Protein

Post-transcriptional regulator mkt1

Gene

mkt1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in post-transcriptional regulation of gene expression by 3'-UTR-mediated RNA regulation (PubMed:31822915).

Promotes interactions between mRNA and poly(A)-binding protein (PubMed:31822915).

Binds the 3' UTR of mRNAs, centromeric transcripts and antisense-rDNA (PubMed:31822915).

Required for the establishment but not the maintenance of heterochromatin at pericentromeres, and for the maintenance of small domains of facultative heterochromatin known as HOODs (PubMed:31822915).

1 Publication

Caution

Although it belongs to the XPG/RAD2 endonuclease family, only two of the seven Asp residues involved in Mg2+ binding are conserved suggesting that it has no nuclease activity.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 5'-flap endonuclease activity Source: GO_Central
  • mRNA 3'-UTR binding Source: PomBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranslation regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Post-transcriptional regulator mkt1Imported
Alternative name(s):
Inactive endonuclease mkt1Curated
Post-transcriptional RNA stability regulator mkt1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mkt1Imported
ORF Names:SPAC139.01cImported, SPAC955.02cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPAC139.01c

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPAC139.01c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Abnormal establishment of heterochromatin (PubMed:31822915). Increased level of RNA-DNA hybrids (PubMed:31822915).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi8 – 12LFIID → AAAAA: Normal chromatin silencing by small RNA. 1 Publication5
Mutagenesisi32D → A: Normal chromatin silencing by small RNA. 1 Publication1
Mutagenesisi201D → A: Normal chromatin silencing by small RNA. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001540481 – 802Post-transcriptional regulator mkt1Add BLAST802

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei227Phosphoserine1 Publication1
Modified residuei228Phosphoserine1 Publication1
Modified residuei230Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UTN2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UTN2

PRoteomics IDEntifications database

More...
PRIDEi
Q9UTN2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UTN2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with pab1 binding protein ath1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
278256, 52 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UTN2, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4896.SPAC139.01c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the XPG/RAD2 endonuclease family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVHA, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_378548_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UTN2

Identification of Orthologs from Complete Genome Data

More...
OMAi
AIWRFLH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UTN2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022039, MKT1_C
IPR022040, MKT1_N
IPR029060, PIN-like_dom_sf
IPR006084, XPG/Rad2
IPR006085, XPG_DNA_repair_N

The PANTHER Classification System

More...
PANTHERi
PTHR11081, PTHR11081, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12246, MKT1_C, 1 hit
PF12247, MKT1_N, 1 hit
PF00752, XPG_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00485, XPGN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF88723, SSF88723, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9UTN2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTIRSLNLFI IDKKHQHKSS LSSFQNCKLG IDASFYLTQI IHSFTPQELQ
60 70 80 90 100
SLAVNGESEY LQHRISEFLE QLRTENITPI FVFNGIPLTF EASSQLEVPG
110 120 130 140 150
KQKSHSALTD FEAFDPYDAN IQRNMYRMDA SGPANYGESK PTLLYTNQRD
160 170 180 190 200
HLDRLCDQVK FYLDQCNVEY FVAPYLAMAQ LAYFLNGTSS PYIDAIYGST
210 220 230 240 250
DLLLFGVKKF ITSMNTSSNV KISSDPSSPS TQTTINSAAK SSFTWLDGNA
260 270 280 290 300
LLQDTNGLSW QQFIDSCLLC GTAISPTFPQ IEGTFLIKSA MELVRMFGSA
310 320 330 340 350
YRAVLHFAEI FPQPIFQDYL QQYKRAVCFS KFGIVMDTKG LTLPPVPTES
360 370 380 390 400
VPNDINIYFG TRLPNEIYFY ISRGLIPCKM IGALVSGCFS DPVSILEQHI
410 420 430 440 450
GDKASQGTFS GANSGLNPGR DNAAAVAAVD QRRFVDDLEE IWSQGLNLLT
460 470 480 490 500
QPLNRFYQAR DIVSLHGHNQ QASLKVMHSY DPPLYNDTRA WMIYEENLPS
510 520 530 540 550
YLSSNFLKEE PVVLFDLLRA LNDPVFVKKS FCTEGNIGIK NPPKHPLSST
560 570 580 590 600
AEIVLSSCYR FLQIRSFVLT SHQLTSWGCP LLKALENCHL QNQTSVVVLF
610 620 630 640 650
ELLRLRQLKE PSLLSSSSAS IADLSITSAT EFLAKVATFL PIKQRPEVSK
660 670 680 690 700
ISIVDENLLQ FYQLQTSFGS NLKELMAMIL ASVILNRNVD KSKIDPKLIR
710 720 730 740 750
KTLPFQNING SLVSGFVVKR FFEIISKEQE ASSQQENIQK AYEIIEKEFP
760 770 780 790 800
TIGSAENHIA QFLEFWKTFM EGVKEAENTS AIGKLVLSKL FLTNQWIFSL

GL
Length:802
Mass (Da):90,153
Last modified:March 29, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83654B3E6BE085D2
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13838 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti608L → F in BAA13838 (PubMed:9501991).Curated1
Sequence conflicti623D → N in BAA13838 (PubMed:9501991).Curated1
Sequence conflicti626I → M in BAA13838 (PubMed:9501991).Curated1
Sequence conflicti649S → C in BAA13838 (PubMed:9501991).Curated1
Sequence conflicti688N → K in BAA13838 (PubMed:9501991).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB88876.3
D89176 mRNA Translation: BAA13838.1 Frameshift.

Protein sequence database of the Protein Information Resource

More...
PIRi
T37602
T42541

NCBI Reference Sequences

More...
RefSeqi
XP_001713046.1, XM_001712994.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC139.01c.1; SPAC139.01c.1:pep; SPAC139.01c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB88876.3
D89176 mRNA Translation: BAA13838.1 Frameshift.
PIRiT37602
T42541
RefSeqiXP_001713046.1, XM_001712994.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi278256, 52 interactors
IntActiQ9UTN2, 1 interactor
STRINGi4896.SPAC139.01c.1

PTM databases

iPTMnetiQ9UTN2

Proteomic databases

MaxQBiQ9UTN2
PaxDbiQ9UTN2
PRIDEiQ9UTN2

Genome annotation databases

EnsemblFungiiSPAC139.01c.1; SPAC139.01c.1:pep; SPAC139.01c

Organism-specific databases

PomBaseiSPAC139.01c
VEuPathDBiFungiDB:SPAC139.01c

Phylogenomic databases

eggNOGiENOG502QVHA, Eukaryota
HOGENOMiCLU_378548_0_0_1
InParanoidiQ9UTN2
OMAiAIWRFLH
PhylomeDBiQ9UTN2

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9UTN2

Family and domain databases

InterProiView protein in InterPro
IPR022039, MKT1_C
IPR022040, MKT1_N
IPR029060, PIN-like_dom_sf
IPR006084, XPG/Rad2
IPR006085, XPG_DNA_repair_N
PANTHERiPTHR11081, PTHR11081, 1 hit
PfamiView protein in Pfam
PF12246, MKT1_C, 1 hit
PF12247, MKT1_N, 1 hit
PF00752, XPG_N, 1 hit
SMARTiView protein in SMART
SM00485, XPGN, 1 hit
SUPFAMiSSF88723, SSF88723, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMKT1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UTN2
Secondary accession number(s): P78828, Q9P6S7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: April 7, 2021
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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