Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 129 (29 Sep 2021)
Sequence version 1 (01 May 2000)
Previous versions | rss
Add a publicationFeedback
Protein

Nucleoporin alm1

Gene

alm1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Maintains the proteasome and its anchor cut8 at the nucleus envelope and is required for kinetochore component proteostasis (PubMed:28974540).

Proper kinetochore stoichiometry ensures the correct attachment of kinetochores to spindle microtubules during cytokinesis (PubMed:28974540, PubMed:10660053).

Required for the localization of spindle assembly checkpoint (SAC) protein mad2 and bub1 to the nucleus envelope during interphase, but not their localization during mitosis (PubMed:28974540).

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoporin alm11 Publication
Alternative name(s):
Abnormal long morphology protein 1
Sp8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:alm11 Publication
ORF Names:SPAC1486.04cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPAC1486.04c, alm1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPAC1486.04c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Decreases cut8 localization to the nuclear envelope (PubMed:28974540). Increases kinetochore component protein levels, including cnp3 (PubMed:28974540). Asynchronous kinetochore segregation during metaphase, with lagging kinetochores present during anaphase B (PubMed:28974540). Increases spindle assembly checkpoint (SAC) activation and results in mitotic metaphase/anaphase transition delay (PubMed:28974540). Abnormal chromosome segregation; lagging mitotic chromosomes during anaphase B and unequal mitotic sister chromatid segregation (PubMed:28974540). Sensitive to thiabendazole (PubMed:28974540). Simultaneous disruption of spindle assembly checkpoint (SAC) proteins bub1 or mad2 results in a growth defect (PubMed:28974540).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000645651 – 1727Nucleoporin alm1Add BLAST1727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1706Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UTK5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UTK5

PRoteomics IDEntifications database

More...
PRIDEi
Q9UTK5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UTK5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
279328, 220 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC1486.04c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UTK5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1423 – 1459DisorderedSequence analysisAdd BLAST37
Regioni1477 – 1500DisorderedSequence analysisAdd BLAST24
Regioni1656 – 1727DisorderedSequence analysisAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili57 – 361Sequence analysisAdd BLAST305
Coiled coili443 – 463Sequence analysisAdd BLAST21
Coiled coili542 – 740Sequence analysisAdd BLAST199
Coiled coili804 – 1106Sequence analysisAdd BLAST303
Coiled coili1223 – 1427Sequence analysisAdd BLAST205
Coiled coili1497 – 1555Sequence analysisAdd BLAST59
Coiled coili1601 – 1664Sequence analysisAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1423 – 1452Polar residuesSequence analysisAdd BLAST30
Compositional biasi1669 – 1686Polar residuesSequence analysisAdd BLAST18
Compositional biasi1700 – 1718Polar residuesSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4674, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_240701_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UTK5

Identification of Orthologs from Complete Genome Data

More...
OMAi
NEHKINT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UTK5

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9UTK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSGGLEDDI QLVHEFLDVS FEDIKPLVSV NGFAVFISAI KTKVKDINAL
60 70 80 90 100
KDQLVLQEVN HEHKENVLTK KINFLEQQLQ SSNNQAEESR NLISVLRNEN
110 120 130 140 150
ESLKTNLENQ NKRFDALTTE NQSLRRANSE LQEQSKIASE QLSIAKDQIE
160 170 180 190 200
ALQNENSHLG EQVQSAHQAL SDIEERKKQH MFASSSSRVK EEILVQEKSA
210 220 230 240 250
LVSDLASLQS DHSKVCEKLE VSSRQVQDLE KKLAGLAQQN TELNEKIQLF
260 270 280 290 300
EQKRSNYSSD GNISKILETD PTSIKELEEE VETQKRLTAL WESKSSELQS
310 320 330 340 350
EVAALQEKLT SQQSLYNNVT EELNNNKQQL LISENSLREL QEKYDSVVSE
360 370 380 390 400
LQVVKENKNT SVSAGVGLFS PLAQKLSAVQ NPEFSFTKVY SDNMKLQQKV
410 420 430 440 450
SSLKLQLDRL TNKFSSFCEQ VKQRIPVVKQ QRSEIVRNNI YMNFLSESLE
460 470 480 490 500
TSNNNLTKVQ AELLSTKMRQ EACYLQLTAS RTQCSDLSRE VICLMAELDH
510 520 530 540 550
LNETKSRNVP ATVQVALDEY AQNPSTASET LVNKELANFS SIKEAVSKTL
560 570 580 590 600
ELREKVRALE CDVEIQKQTV QYQISNAVKE NSNTLSEQIK NLESELNSSK
610 620 630 640 650
IKNESLLNER NLLKEMLATS RSSILSHNSS AGNIDDKMKS IDESTRELEK
660 670 680 690 700
NYEVYRNEMT AIQESLSKRN QDLLSEMEAI RKELENSKYQ QQLSTDRLTN
710 720 730 740 750
ANNDVEAFKK EAKELRSINQ NLQDIISRQD QRASKFAEEL LHVNSLAERL
760 770 780 790 800
KGELNASKGE KDLRKRTQER LISENDKLLA ERERLMSLVS DLQTFLNQQQ
810 820 830 840 850
LSDAARKVKF ESEKESLSLS LQKLKESNEK MSNDLHSLQK SLEKSGIEYS
860 870 880 890 900
SRIKTLMLEK QSLSEDNRKL LDNQQMMEIK LQELNGVIEL EKQRFSTLEA
910 920 930 940 950
KFTQQKNTSY SEREALLESS LSDLQSKHTS LESQYNYSLR NIEQLQAASK
960 970 980 990 1000
LAEEMVERVK TEYDEYRLQT SESLEKNHLK ITSLEQRIVI LQDEIASSSL
1010 1020 1030 1040 1050
RCENITKDSE TRVALLLEEN KHLNNELSSH RNAEKQHLEK ENDYKQQLLL
1060 1070 1080 1090 1100
VTEDLRKTRE DYEKELLRHA DARSTLQKLR EDYTKALEQV EDLNKEIALK
1110 1120 1130 1140 1150
AGINESQPFP ISEKEDPLRQ EVYVLKKQNA MLLTQLQSSN LNFAEITSPS
1160 1170 1180 1190 1200
PDLDSVMKLG LSDLQNHVKR ISKEMEIISC QRQLLFLENK KLKRTVESSN
1210 1220 1230 1240 1250
RVIADLQRGI TEKDVSSTSE SVGERSNYLN MVALLNESNK SLRENLERNE
1260 1270 1280 1290 1300
EVITELREKI ETLKTDLANF RLNKEQLESQ LQTEKAAVKK LENSNEEYKR
1310 1320 1330 1340 1350
HNQEILLSLN SSTSTSSDAS RLKNELVSKE NLIEELNQEI GHLKSELETV
1360 1370 1380 1390 1400
KSKSEDLENE RAQNQSKIEQ LELKNTKLAA AWRTKYEQVV NKSLEKHNQI
1410 1420 1430 1440 1450
RQQLSQKTSE LEAKVAECHQ LNEQLNKPSA TPTATTQSEP STVSLEEFNS
1460 1470 1480 1490 1500
TKEELSSTQR KLSEIMDILN TTKEELEKVR QNSNKSEGTS KDTEIPNEEE
1510 1520 1530 1540 1550
MERKKVMQQE VLRLRSRIAK ELQKNELLRK QNQVLQDQVK ALQETVVSSE
1560 1570 1580 1590 1600
EAESASVHAD TKDLENLKKT EEMLSVTFQV IFNESISDFS TSTADFTTFV
1610 1620 1630 1640 1650
QKEWEKRREI LQKDVEEQVA QSHQKQLDNI RKELEMRNKL KLSMLEKNLA
1660 1670 1680 1690 1700
RVRAELEQSK KKDSPAILSL EASKNTDSNK SNSEVPAAQV KEKKLIAKTH
1710 1720
SVDTNSPPKR SSSDAGMDVS NDVKKAK
Length:1,727
Mass (Da):197,860
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF820BF8D9C132644
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB65416 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB62414.1
AF010473 mRNA Translation: AAB65416.1 Different initiation.
AB028012 Genomic DNA Translation: BAA87316.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T43527
T50073

NCBI Reference Sequences

More...
RefSeqi
NP_594092.1, NM_001019516.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC1486.04c.1; SPAC1486.04c.1:pep; SPAC1486.04c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2542883

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC1486.04c

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB62414.1
AF010473 mRNA Translation: AAB65416.1 Different initiation.
AB028012 Genomic DNA Translation: BAA87316.1
PIRiT43527
T50073
RefSeqiNP_594092.1, NM_001019516.2

3D structure databases

SMRiQ9UTK5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi279328, 220 interactors
STRINGi4896.SPAC1486.04c.1

PTM databases

iPTMnetiQ9UTK5

Proteomic databases

MaxQBiQ9UTK5
PaxDbiQ9UTK5
PRIDEiQ9UTK5

Genome annotation databases

EnsemblFungiiSPAC1486.04c.1; SPAC1486.04c.1:pep; SPAC1486.04c
GeneIDi2542883
KEGGispo:SPAC1486.04c

Organism-specific databases

PomBaseiSPAC1486.04c, alm1
VEuPathDBiFungiDB:SPAC1486.04c

Phylogenomic databases

eggNOGiKOG4674, Eukaryota
HOGENOMiCLU_240701_0_0_1
InParanoidiQ9UTK5
OMAiNEHKINT
PhylomeDBiQ9UTK5

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9UTK5

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALM1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UTK5
Secondary accession number(s): O13313, Q9UTT8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 2000
Last modified: September 29, 2021
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again