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Entry version 130 (02 Jun 2021)
Sequence version 1 (01 May 2000)
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Protein

Multicopy suppressor of chk1 protein 1

Gene

msc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a role in regulating chromatin structure via global deacetylation of histone H3. This function is associated with the activity of a histone deacetylase.

1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri298 – 345PHD-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri1171 – 1220PHD-type 2PROSITE-ProRule annotationAdd BLAST50
Zinc fingeri1454 – 1505PHD-type 3PROSITE-ProRule annotationAdd BLAST52

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multicopy suppressor of chk1 protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:msc1
ORF Names:SPAC343.11c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPAC343.11c, msc1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPAC343.11c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000965901 – 1588Multicopy suppressor of chk1 protein 1Add BLAST1588

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UT79

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UT79

PRoteomics IDEntifications database

More...
PRIDEi
Q9UT79

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UT79

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
278205, 124 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UT79, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4896.SPAC343.11c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini82 – 124JmjNPROSITE-ProRule annotationAdd BLAST43
Domaini475 – 645JmjCPROSITE-ProRule annotationAdd BLAST171

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni38 – 60DisorderedSequence analysisAdd BLAST23
Regioni385 – 412DisorderedSequence analysisAdd BLAST28
Regioni848 – 872DisorderedSequence analysisAdd BLAST25
Regioni1319 – 1341DisorderedSequence analysisAdd BLAST23

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri298 – 345PHD-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri1171 – 1220PHD-type 2PROSITE-ProRule annotationAdd BLAST50
Zinc fingeri1454 – 1505PHD-type 3PROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1246, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_247392_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UT79

Identification of Orthologs from Complete Genome Data

More...
OMAi
VEMKVCL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UT79

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003347, JmjC_dom
IPR003349, JmjN
IPR013637, Lys_sp_deMease-like_dom
IPR019786, Zinc_finger_PHD-type_CS
IPR004198, Znf_C5HC2
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02373, JmjC, 1 hit
PF00628, PHD, 1 hit
PF08429, PLU-1, 1 hit
PF02928, zf-C5HC2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00558, JmjC, 1 hit
SM00545, JmjN, 1 hit
SM00249, PHD, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903, SSF57903, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51184, JMJC, 1 hit
PS51183, JMJN, 1 hit
PS01359, ZF_PHD_1, 3 hits
PS50016, ZF_PHD_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9UT79-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKNSSHENQ SSENIIEFPY VDFEELNVHS NIFSELEHAK PSTQQQQQQQ
60 70 80 90 100
NISNETTSTG PRICISRDEF KAVNLLTKEE INVRVTPKKE EFSRGLDFIS
110 120 130 140 150
DLYDQTARKS GAVRVIPPDN WKCPLTINTT TFKFLTRKNN PSSMSLVSNY
160 170 180 190 200
PLDAISSQQK FHGNDKTLEK NSAKATINKS NSTAETSSTA TVEPYDSNDL
210 220 230 240 250
YRIFDRPDAV VLSYIFVLGK AVDLLQIKQW LQLSKQKNLL EFEFWSQAAQ
260 270 280 290 300
HYKLDVNSLR NAYNLYAETG VTTRTGNDGG SPINRPAKRV KRQNHIPKCK
310 320 330 340 350
LCAQEGSSLV TCCICQSNYH YACVEAPFAP FSDIHYWTCN SCIPSSLKIL
360 370 380 390 400
WKEVDYHCIS SFLQSSNELA SSLKKQLPSF LAQTPLTLPS NTKTPPASAR
410 420 430 440 450
QSSRRTRSTS GKGFETKISI NLDSDIKLLN TLSPLETFFW CCSFPSTAST
460 470 480 490 500
SSPFSYYPES LPTPLLGRAV NTTAFPTSRQ NAYYNDPWNL YFIHFSKLSP
510 520 530 540 550
LRFTPPGILT STISLGQPLT CQGWQRDSMS LFGMHYHHYG AQRIWYVIPE
560 570 580 590 600
VDGPKYEKLL NDLSPSFIQE KPETLIKSKI LLPISMLISN GIQVLTFVQN
610 620 630 640 650
SNEFVITSPN TYYTVLDTGF SLSESVPFAT KEWIQDMHAE NSFNMYKNLH
660 670 680 690 700
ISAPFSLDHI LLANATLDKT VHSAYWLMTC LKDRVDRELT LRNEFRKRHP
710 720 730 740 750
LLTWIPTPLE SSVMACAFCK TFAYLASIEE KNGTKTACLS HKDECFPNTD
760 770 780 790 800
SDLTVLVRYD DNALLAAYSK VVERAHKADT WLENYKEALG SDNSRPSLKV
810 820 830 840 850
LKTLLNEAET ICCPLQEVSL VRNLVKTAQQ WLDKFAIIFK KKSMVKKEKR
860 870 880 890 900
KPKRGSATHS HLESPSEEVE DLNSSNINEA DLLINLVEEA EQFTFDFPEM
910 920 930 940 950
AVAFEKAESL KIFREKANAM KERSLSYEEC LAIVEEGESL QLKTPELLYF
960 970 980 990 1000
KQYMEKTEWI DSFNQISQKT DSTMEELVEL IERGEKIGLT SDNENMATAL
1010 1020 1030 1040 1050
LLKEKSENWM KQVEGLLSQE TLSTSKLFQL KSEANSICIN RGLLEQLNEV
1060 1070 1080 1090 1100
LQKSENFHTQ LVSLISRARD PDYYSRPTIE EAKTVLAESE NLTNKPEEYT
1110 1120 1130 1140 1150
VAQKLLTQTY EWVRRGKRLF GKANAPLEIF NQHLEFVEQR NTNAMVDEGS
1160 1170 1180 1190 1200
DAPFHVGNEY YVIAGSDPSD FHYCFCRQPE AGMMIECELC HEWYHAKCMK
1210 1220 1230 1240 1250
MSKKKLRADE KFICPICDYR VEVPRHSHRP PLIELQKMVD DIPTLPFQPI
1260 1270 1280 1290 1300
EIELLKRVVK QAEEFKNKMQ SEVCDPTQLS EKDVPLLQFY LRKLEGSEIL
1310 1320 1330 1340 1350
FTEELNVFRQ KLHEFMPVAP QPPPFIGESR SNRKPRPTKR QREIMEQVES
1360 1370 1380 1390 1400
GKLTSAEGAA AIAATQTRNQ NNFISKPFNV HTLSTTLSPW AMKSLAQAAI
1410 1420 1430 1440 1450
SPNPMPSAHD LLPTSNPAEL FTNISPEIKE LSVDSTSTLG GLNSSHLVSD
1460 1470 1480 1490 1500
QNASVICLCR QPFAISDGTV QCHNCLEWFH YECVGLSSDI VSTLSNYACP
1510 1520 1530 1540 1550
DCCSKEGKLY PWNTRPRSTP SVWLSQAYSP SVLQGTTENV AFLNKAFSAS
1560 1570 1580
ANLFDVLPVS NTPSHFSKMD YVLEDRKPDL FTETYLSM
Length:1,588
Mass (Da):180,352
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D18248ABB3DBC55
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB52274.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T38660

NCBI Reference Sequences

More...
RefSeqi
NP_593431.1, NM_001018864.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC343.11c.1; SPAC343.11c.1:pep; SPAC343.11c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2541710

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC343.11c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB52274.1
PIRiT38660
RefSeqiNP_593431.1, NM_001018864.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi278205, 124 interactors
IntActiQ9UT79, 1 interactor
STRINGi4896.SPAC343.11c.1

PTM databases

iPTMnetiQ9UT79

Proteomic databases

MaxQBiQ9UT79
PaxDbiQ9UT79
PRIDEiQ9UT79

Genome annotation databases

EnsemblFungiiSPAC343.11c.1; SPAC343.11c.1:pep; SPAC343.11c
GeneIDi2541710
KEGGispo:SPAC343.11c

Organism-specific databases

PomBaseiSPAC343.11c, msc1
VEuPathDBiFungiDB:SPAC343.11c

Phylogenomic databases

eggNOGiKOG1246, Eukaryota
HOGENOMiCLU_247392_0_0_1
InParanoidiQ9UT79
OMAiVEMKVCL
PhylomeDBiQ9UT79

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9UT79

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR003347, JmjC_dom
IPR003349, JmjN
IPR013637, Lys_sp_deMease-like_dom
IPR019786, Zinc_finger_PHD-type_CS
IPR004198, Znf_C5HC2
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF02373, JmjC, 1 hit
PF00628, PHD, 1 hit
PF08429, PLU-1, 1 hit
PF02928, zf-C5HC2, 1 hit
SMARTiView protein in SMART
SM00558, JmjC, 1 hit
SM00545, JmjN, 1 hit
SM00249, PHD, 3 hits
SUPFAMiSSF57903, SSF57903, 3 hits
PROSITEiView protein in PROSITE
PS51184, JMJC, 1 hit
PS51183, JMJN, 1 hit
PS01359, ZF_PHD_1, 3 hits
PS50016, ZF_PHD_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMSC1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UT79
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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