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UniProtKB - Q9UT76 (EI2BB_SCHPO)
Protein
Probable translation initiation factor eIF-2B subunit beta
Gene
tif222
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
By similarityGO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: PomBase
- translation initiation factor activity Source: PomBase
GO - Biological processi
- cytoplasmic translational initiation Source: PomBase
- translational initiation Source: GO_Central
Keywordsi
Molecular function | Initiation factor |
Biological process | Protein biosynthesis, Translation regulation |
Enzyme and pathway databases
Reactomei | R-SPO-72731, Recycling of eIF2:GDP |
Names & Taxonomyi
Protein namesi | Recommended name: Probable translation initiation factor eIF-2B subunit betaAlternative name(s): eIF-2B GDP-GTP exchange factor subunit beta |
Gene namesi | Name:tif222 ORF Names:SPAC343.14c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC343.14c, tif222 |
VEuPathDBi | FungiDB:SPAC343.14c |
Subcellular locationi
Cytosol
- cytosol Source: PomBase
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- eukaryotic translation initiation factor 2B complex Source: PomBase
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317323 | 1 – 393 | Probable translation initiation factor eIF-2B subunit betaAdd BLAST | 393 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 106 | Phosphoserine1 Publication | 1 | |
Modified residuei | 108 | Phosphoserine1 Publication | 1 | |
Modified residuei | 112 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q9UT76 |
PaxDbi | Q9UT76 |
PTM databases
iPTMneti | Q9UT76 |
Interactioni
Subunit structurei
Complex of five different subunits; alpha, beta, gamma, delta and epsilon.
By similarityBinary interactionsi
Q9UT76
With | #Exp. | IntAct |
---|---|---|
tif211 [P56286] | 2 | EBI-16198490,EBI-16198594 |
Protein-protein interaction databases
BioGRIDi | 279470, 9 interactors |
DIPi | DIP-61959N |
IntActi | Q9UT76, 3 interactors |
STRINGi | 4896.SPAC343.14c.1 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q9UT76 |
SMRi | Q9UT76 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 105 – 125 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the eIF-2B alpha/beta/delta subunits family.Curated
Phylogenomic databases
eggNOGi | KOG1465, Eukaryota |
HOGENOMi | CLU_016218_4_3_1 |
InParanoidi | Q9UT76 |
OMAi | TSHTSYA |
PhylomeDBi | Q9UT76 |
Family and domain databases
Gene3Di | 1.20.120.420, 1 hit 3.40.50.10470, 1 hit |
InterProi | View protein in InterPro IPR000649, IF-2B-related IPR042529, IF_2B-like_C IPR027363, M1Pi_N IPR037171, NagB/RpiA_transferase-like |
Pfami | View protein in Pfam PF01008, IF-2B, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9UT76-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTINVEHTY PAVSSLIADL KSRKVQGPFA VAVETALVMR QVISQTRWST
60 70 80 90 100
VDQLIDTVRA VGSTLVKAQP TEFSCGNIIR RILRLIREEY QELLKTADEN
110 120 130 140 150
EKLIVSSSNS SSPSQKRDIP SNEKLVQSHE PVSVQMYSSM LNLLGRPTLE
160 170 180 190 200
SPTHSKTVGD SRVTGGMDMR AVIISGIQDV IDELDKINTD IEVQSMDHLH
210 220 230 240 250
SNEIILTQGC SKTVEAFLRF AAKKRKFSVI VAEGFPNNQK GSHAMAKRLA
260 270 280 290 300
QAGIDTTVIS DATIFAIMSR VNKVILGTHA ILGNGGLVTY SGAQLVAQAA
310 320 330 340 350
RHHATPVVVC SGIYKLSPVY PYDLESIIQL SSPDKIMSFN EGDLISRAEI
360 370 380 390
LNPYYDYIPP DLVDLFITNL GGYPPSYLYR IMNDTYDASD TIL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB52277.1 |
PIRi | T38663 |
RefSeqi | NP_593435.1, NM_001018868.2 |
Genome annotation databases
EnsemblFungii | SPAC343.14c.1; SPAC343.14c.1:pep; SPAC343.14c |
GeneIDi | 2543035 |
KEGGi | spo:SPAC343.14c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB52277.1 |
PIRi | T38663 |
RefSeqi | NP_593435.1, NM_001018868.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5B04 | X-ray | 2.99 | C/D | 1-393 | [»] | |
6JLY | X-ray | 3.50 | C/D | 1-393 | [»] | |
6JLZ | X-ray | 3.35 | C/D | 1-393 | [»] | |
AlphaFoldDBi | Q9UT76 | |||||
SMRi | Q9UT76 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 279470, 9 interactors |
DIPi | DIP-61959N |
IntActi | Q9UT76, 3 interactors |
STRINGi | 4896.SPAC343.14c.1 |
PTM databases
iPTMneti | Q9UT76 |
Proteomic databases
MaxQBi | Q9UT76 |
PaxDbi | Q9UT76 |
Genome annotation databases
EnsemblFungii | SPAC343.14c.1; SPAC343.14c.1:pep; SPAC343.14c |
GeneIDi | 2543035 |
KEGGi | spo:SPAC343.14c |
Organism-specific databases
PomBasei | SPAC343.14c, tif222 |
VEuPathDBi | FungiDB:SPAC343.14c |
Phylogenomic databases
eggNOGi | KOG1465, Eukaryota |
HOGENOMi | CLU_016218_4_3_1 |
InParanoidi | Q9UT76 |
OMAi | TSHTSYA |
PhylomeDBi | Q9UT76 |
Enzyme and pathway databases
Reactomei | R-SPO-72731, Recycling of eIF2:GDP |
Miscellaneous databases
PROi | PR:Q9UT76 |
Family and domain databases
Gene3Di | 1.20.120.420, 1 hit 3.40.50.10470, 1 hit |
InterProi | View protein in InterPro IPR000649, IF-2B-related IPR042529, IF_2B-like_C IPR027363, M1Pi_N IPR037171, NagB/RpiA_transferase-like |
Pfami | View protein in Pfam PF01008, IF-2B, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EI2BB_SCHPO | |
Accessioni | Q9UT76Primary (citable) accession number: Q9UT76 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families