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Protein

E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp2

Gene

rfp2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Involved in maintaining genome stability where it acts in the cellular response to DNA damage.3 Publications

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri147 – 190RING-type; degeneratePROSITE-ProRule annotationAdd BLAST44

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: PomBase
  • DNA repair Source: PomBase
  • negative regulation of protein sumoylation Source: PomBase
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
  • protein ubiquitination Source: GO_Central
  • ubiquitin-dependent protein catabolic process Source: PomBase

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp2 (EC:2.3.2.27)
Alternative name(s):
RING finger protein 2
RING-type E3 ubiquitin transferase rfp2Curated
Gene namesi
Name:rfp2
ORF Names:SPAC343.18
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC343.18
PomBaseiSPAC343.18 rfp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003588731 – 205E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp2Add BLAST205

Proteomic databases

PaxDbiQ9UT72
PRIDEiQ9UT72

Interactioni

Subunit structurei

Part of an E3 ubiquitin complex including rfp1, rfp2 and slx8. Interacts with slx8.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
slx8P871763EBI-7587772,EBI-7588105

Protein-protein interaction databases

BioGridi279621, 16 interactors
ELMiQ9UT72
IntActiQ9UT72, 4 interactors
MINTiQ9UT72
STRINGi4896.SPAC343.18.1

Structurei

3D structure databases

ProteinModelPortaliQ9UT72
SMRiQ9UT72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri147 – 190RING-type; degeneratePROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Zinc-finger

Phylogenomic databases

InParanoidiQ9UT72
OrthoDBiEOG092C4VMD

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00097 zf-C3HC4, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UT72-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLHGLELPG RDQRLSPEVI DLTEDIEDDG ADVSEVTLLD LTRIPEFQPR
60 70 80 90 100
RRIRTSRNHL DANLSNVPTI NSIPSPVTRP PVAVGGGIFY GARRTRNRSQ
110 120 130 140 150
TQRRTLLENG FRNSRKKAQD SSNSIAERVS PPPGFCYDVH PHNNIACAKC
160 170 180 190 200
GNELVSDEKK SIFAAKCGHL FCSTCAKELR KKTVPCPVQH CRKRITKKFI

FPLYL
Length:205
Mass (Da):23,060
Last modified:May 1, 2000 - v1
Checksum:iC4BF42106B1F55AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB52281.1
PIRiT38667
RefSeqiNP_593439.1, NM_001018872.2

Genome annotation databases

EnsemblFungiiSPAC343.18.1; SPAC343.18.1:pep; SPAC343.18
GeneIDi2543192
KEGGispo:SPAC343.18

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB52281.1
PIRiT38667
RefSeqiNP_593439.1, NM_001018872.2

3D structure databases

ProteinModelPortaliQ9UT72
SMRiQ9UT72
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279621, 16 interactors
ELMiQ9UT72
IntActiQ9UT72, 4 interactors
MINTiQ9UT72
STRINGi4896.SPAC343.18.1

Proteomic databases

PaxDbiQ9UT72
PRIDEiQ9UT72

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC343.18.1; SPAC343.18.1:pep; SPAC343.18
GeneIDi2543192
KEGGispo:SPAC343.18

Organism-specific databases

EuPathDBiFungiDB:SPAC343.18
PomBaseiSPAC343.18 rfp2

Phylogenomic databases

InParanoidiQ9UT72
OrthoDBiEOG092C4VMD

Enzyme and pathway databases

UniPathwayi
UPA00143

Miscellaneous databases

PROiPR:Q9UT72

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00097 zf-C3HC4, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRFP2_SCHPO
AccessioniPrimary (citable) accession number: Q9UT72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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