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UniProtKB - Q9UT61 (MAN1_SCHPO)

Entry version 120 (23 Feb 2022)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein

Alpha-mannosidase

Gene

ams1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Degrades free oligosaccharides in the vacuole.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. EC:3.2.1.24

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi290ZincBy similarity1
Metal bindingi292ZincBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei402NucleophileBy similarity1
Metal bindingi402ZincBy similarity1
Metal bindingi615ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-SPO-8853383, Lysosomal oligosaccharide catabolism

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GH38, Glycoside Hydrolase Family 38

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-mannosidase (EC:3.2.1.24)
Alternative name(s):
Alpha-D-mannoside mannohydrolase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ams1
Synonyms:mns2
ORF Names:SPAC513.05
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...PomBasei		SPAC513.05, ams1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:SPAC513.05

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003633891 – 1077Alpha-mannosidaseAdd BLAST1077

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UT61

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UT61

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UT61

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		279905, 1 interactor

STRING: functional protein association networks

More...STRINGi		4896.SPAC513.05.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11077
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UT61

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 38 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4342, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003442_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UT61

Identification of Orthologs from Complete Genome Data

More...OMAi		GQYWDAW

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UT61

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1270.50, 1 hit
3.20.110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011013, Gal_mutarotase_sf_dom
IPR041147, GH38_C
IPR011330, Glyco_hydro/deAcase_b/a-brl
IPR011682, Glyco_hydro_38_C
IPR015341, Glyco_hydro_38_cen
IPR037094, Glyco_hydro_38_cen_sf
IPR000602, Glyco_hydro_38_N
IPR027291, Glyco_hydro_38_N_sf
IPR028995, Glyco_hydro_57/38_cen_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09261, Alpha-mann_mid, 1 hit
PF17677, Glyco_hydro38C2, 1 hit
PF07748, Glyco_hydro_38C, 1 hit
PF01074, Glyco_hydro_38N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00872, Alpha-mann_mid, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF74650, SSF74650, 1 hit
SSF88688, SSF88688, 1 hit
SSF88713, SSF88713, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9UT61-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLFPVLNNT PVGKQVDSIY ESRLDQFLSE GQYRDFNLPS VYDHARIDNP 
        60         70         80         90        100
SGDVNNDLSK GFVDLKVYRV PDLSRPSFNE VVGHKKFDET ASKGDTFGPS 
       110        120        130        140        150
WATFWFEVHI RLPKSWAKYE QVIFQWNCDN EGLVYSQDGV PLQAFSGSER 
       160        170        180        190        200
TDFILPDSWK TTEDTFYIEM ACNGMFGTGA GSQIAPPDPN RYFTLTKADL 
       210        220        230        240        250
VAPNLPAMAL AYDFLLMQQC VKQLPSNCWQ KYKARQICND IMNTFHPNDL 
       260        270        280        290        300
STINECRNLA KAFLGNDIDS EAVFEKNNDK ANVFAIGHCH IDTAWLWPFA 
       310        320        330        340        350
ETRRKIVRSW ATQMNIMDRY PEYQFVCSQA LQYLWLKEDH PDVFEKLKEY 
       360        370        380        390        400
VNQNKFIPIG GSWVEHDTNI PNGESLIRQF LLGQHFFEKE FGVRCRTFWL 
       410        420        430        440        450
PDTFGYSSQI PQICRLCGMD RFLTQKLSWN NINSFPTSTF NWVALDGSQV 
       460        470        480        490        500
ICHMPPANTY TADTNVNDVL HSIDQHKNLV NDQAGLLVFG IGDGGGGPTP 
       510        520        530        540        550
EMLEKLRRCK GIANTVGYLP NVKLGNTVDE FFDGILKRTN AGQTLPSWNG 
       560        570        580        590        600
ELYFEFHRGT YTTQAELKKL MRKVEIALHD AEYVSTLASI FSKDYSYPKE 
       610        620        630        640        650
SLQDLWRDTL LCQFHDVLPG SCIEMVYKDA IPIMSKVLKN TEALLWQAIE 
       660        670        680        690        700
QLGFKKASSS DNKEQLCLLN TLPWNVRGVI TETEENKLVY FESCDGKGIL 
       710        720        730        740        750
TAAHTSLKHP AAAYQKDDNF ILVNDHLRVT IAPNGLILSL FDLHKEREIL 
       760        770        780        790        800
DLKSGKNHAG ANQYVLFEDT PLSWQAWDTE VFSLEKYEVL DKGKVSIKES 
       810        820        830        840        850
GPLRASVVVD IPISELSHMK ATISLEGYND CSEFTGVNFT CEVDWHESCK 
       860        870        880        890        900
FLKVEFPVDI HSEFASYETQ FGITKRPTHY NTSWDVAKFE VCHQKFADYS 
       910        920        930        940        950
DFTYGVSVLN DCKYGFSTHG NLMRLSLLRS PKQPDAHADM GKHTIRYAVY 
       960        970        980        990       1000
PHSKPLDSST VRAAHKFNSN FRLLTRASDT ANLDIFDAFQ LVGEPNVILS 
      1010       1020       1030       1040       1050
HIKMAEKGKS IILRVYESLG GKSRARLVIK SLTVASVTKC NGLEEDLEEL 
      1060       1070 
CTLKSNDYYE VPIELRAFEI ATFKVNL
Length:1,077
Mass (Da):122,438
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8774DDF4A2194A46
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB58728.1

Protein sequence database of the Protein Information Resource

More...PIRi		T38900

NCBI Reference Sequences

More...RefSeqi		NP_593979.1, NM_001019405.2

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		SPAC513.05.1; SPAC513.05.1:pep; SPAC513.05

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2543485

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		spo:SPAC513.05

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB58728.1
PIRiT38900
RefSeqiNP_593979.1, NM_001019405.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6LZ1electron microscopy3.20A/B/C/D1-1077[»]
7DD9electron microscopy2.40A/C/E/G1-1077[»]
SMRiQ9UT61
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi279905, 1 interactor
STRINGi4896.SPAC513.05.1

Protein family/group databases

CAZyiGH38, Glycoside Hydrolase Family 38

PTM databases

iPTMnetiQ9UT61

Proteomic databases

MaxQBiQ9UT61
PaxDbiQ9UT61

Genome annotation databases

EnsemblFungiiSPAC513.05.1; SPAC513.05.1:pep; SPAC513.05
GeneIDi2543485
KEGGispo:SPAC513.05

Organism-specific databases

PomBaseiSPAC513.05, ams1
VEuPathDBiFungiDB:SPAC513.05

Phylogenomic databases

eggNOGiKOG4342, Eukaryota
HOGENOMiCLU_003442_0_1_1
InParanoidiQ9UT61
OMAiGQYWDAW
PhylomeDBiQ9UT61

Enzyme and pathway databases

ReactomeiR-SPO-8853383, Lysosomal oligosaccharide catabolism

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9UT61

Family and domain databases

Gene3Di1.20.1270.50, 1 hit
3.20.110.10, 1 hit
InterProiView protein in InterPro
IPR011013, Gal_mutarotase_sf_dom
IPR041147, GH38_C
IPR011330, Glyco_hydro/deAcase_b/a-brl
IPR011682, Glyco_hydro_38_C
IPR015341, Glyco_hydro_38_cen
IPR037094, Glyco_hydro_38_cen_sf
IPR000602, Glyco_hydro_38_N
IPR027291, Glyco_hydro_38_N_sf
IPR028995, Glyco_hydro_57/38_cen_sf
PfamiView protein in Pfam
PF09261, Alpha-mann_mid, 1 hit
PF17677, Glyco_hydro38C2, 1 hit
PF07748, Glyco_hydro_38C, 1 hit
PF01074, Glyco_hydro_38N, 1 hit
SMARTiView protein in SMART
SM00872, Alpha-mann_mid, 1 hit
SUPFAMiSSF74650, SSF74650, 1 hit
SSF88688, SSF88688, 1 hit
SSF88713, SSF88713, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAN1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UT61
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 1, 2000
Last modified: February 23, 2022
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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