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UniProtKB - Q9UT43 (YFRD_SCHPO)
Protein
Putative phospholipid-transporting ATPase C821.13c
Gene
SPAC821.13c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Catalytic activityi
- ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). EC:7.6.2.1
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 684 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 1243 | MagnesiumBy similarity | 1 | |
Metal bindingi | 1247 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATPase-coupled intramembrane lipid transporter activity Source: PomBase
- ATP binding Source: UniProtKB-KW
- magnesium ion binding Source: InterPro
GO - Biological processi
- phospholipid translocation Source: PomBase
Keywordsi
Molecular function | Translocase |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-SPO-6798695, Neutrophil degranulation R-SPO-936837, Ion transport by P-type ATPases |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:SPAC821.13c, SPAC955.01c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC821.13c |
VEuPathDBi | FungiDB:SPAC821.13c |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Golgi apparatus
- integral component of Golgi membrane Source: PomBase
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- trans-Golgi network transport vesicle Source: PomBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 275 | ExtracellularSequence analysisAdd BLAST | 275 | |
Transmembranei | 276 – 296 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 297 – 574 | CytoplasmicSequence analysisAdd BLAST | 278 | |
Transmembranei | 575 – 595 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 596 – 614 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 615 – 635 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 636 – 1309 | CytoplasmicSequence analysisAdd BLAST | 674 | |
Transmembranei | 1310 – 1330 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1331 – 1332 | ExtracellularSequence analysis | 2 | |
Transmembranei | 1333 – 1353 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1354 – 1381 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 1382 – 1402 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1403 – 1414 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 1415 – 1435 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1436 – 1443 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 1444 – 1464 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1465 – 1490 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 1491 – 1511 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1512 – 1562 | CytoplasmicSequence analysisAdd BLAST | 51 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046240 | 1 – 1562 | Putative phospholipid-transporting ATPase C821.13cAdd BLAST | 1562 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 954 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q9UT43 |
PaxDbi | Q9UT43 |
PRIDEi | Q9UT43 |
PTM databases
iPTMneti | Q9UT43 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 280591, 1 interactor |
STRINGi | 4896.SPAC821.13c.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 38 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 55 – 94 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 115 – 134 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 146 – 166 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 347 – 406 | DisorderedSequence analysisAdd BLAST | 60 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 28 | Polar residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 68 – 90 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 347 – 369 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 384 – 406 | Polar residuesSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0206, Eukaryota |
HOGENOMi | CLU_000846_5_2_1 |
InParanoidi | Q9UT43 |
OMAi | FIIMFNT |
PhylomeDBi | Q9UT43 |
Family and domain databases
Gene3Di | 3.40.1110.10, 2 hits 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006539, P-type_ATPase_IV IPR032631, P-type_ATPase_N IPR001757, P_typ_ATPase IPR032630, P_typ_ATPase_c IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF16212, PhoLip_ATPase_C, 1 hit PF16209, PhoLip_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01652, ATPase-Plipid, 2 hits TIGR01494, ATPase_P-type, 1 hit |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9UT43-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKSSGIAGDS NGFETNFLNE TTNREEDGAF NWNAADDGTN ERREDIHVRF
60 70 80 90 100
QDSALPLGID ENELDEIDIN GDSKKLDSVE VDESHDVNSP SDSRLKSSFK
110 120 130 140 150
SVLELTANSM VSVLTPSTKT EQTSKGKGKK KKAHVSFLEG PVEEIPLDDI
160 170 180 190 200
EPTSPREASP VFNGRPPIPP EFLKSRHKEF TIPNPLQFIS NFLSNLFSRD
210 220 230 240 250
TRYLKSSHGR IIIINPYDDS SQIDERTGKP YMQNSIVSSR YNKYNFVPLQ
260 270 280 290 300
IIAQFSKTAN CYFLLIAIMQ MIPGWSTTGT YTTIIPLLIF ISIAILREGF
310 320 330 340 350
DNYRRYRQDR VENRIQTQVL RHVDVDPPIV EEHSSFFRRR RWRRSRSQES
360 370 380 390 400
ASRSTIRSTD EREPERTSED PPQLPPSPSS PSSPALSVKP NIDPQPPLYN
410 420 430 440 450
STLTTTRSIP ANKPTFFWAS CDRKDVRVGD IIRLTSDQTL PADVIALSSP
460 470 480 490 500
NPNGAIYIET AALDGETSLK TRLVNSTLRS LCKDINDLIR LSGTCTVEDP
510 520 530 540 550
NGDLYNFNGS MKLDSIQGEI PLSNNDVLYR GSNLRNTSEL FALVIFTGEE
560 570 580 590 600
SKIRMNAVRN VSVKAPSMQK VTNRIVIFIF ALVVSMAIYC TAAYFVWQKK
610 620 630 640 650
VERKLWYLTN SKLSFVPILV SFIILYNTMV PISLYVSMEI IRVFQTFLVQ
660 670 680 690 700
SDIDLYYPEN DTRCEVRSSS ILEELGQVTH VFSDKTGTLT DNIMLFRNLS
710 720 730 740 750
VGGFAWQHVG AENPKLVSTS QKSDDLDGEA KPPQLENIQG TTIQLLQYVH
760 770 780 790 800
DNPHTTFSKR VRIFLLNLAI CHTCLPSFDE ENQIYKYQSI SPDELALVHA
810 820 830 840 850
AQQLGYIVID RDIDSLTIRL HYPLDPHSHP IAKTYRILNI IEFTSKRKCM
860 870 880 890 900
SVIVRMPNGR ICLFCKGADS AIIKRLRLSN LAKRKDKSVT KAEQARKSIE
910 920 930 940 950
IDKAIIRNSQ STSRPSLTAS RPSLSRRRND YINNVTSWLD ERREKMGVVR
960 970 980 990 1000
PRASTSILET RRRPAVGRHS LAGGERLMED KKYLSKQEEA EGSIYESLNH
1010 1020 1030 1040 1050
NDAKLFENTF EHVHAFATDG LRTLMYAHRF IDESEYQSWK LVNDAALNSL
1060 1070 1080 1090 1100
SNRQQLLDEA ADLIEKDLEF AGATAIEDKL QVGVPESINS LFRAGIKFWM
1110 1120 1130 1140 1150
LTGDKKETAI NIGHSCGVIK EYSTVVVMGS LDGVEGSDET VSGGQRLSLD
1160 1170 1180 1190 1200
RPPTNDPASL MIHQLISCMN AIHSNSLAHL VIVIDGSTLA DIENDPELFL
1210 1220 1230 1240 1250
LFINTAVEAD SVICCRSSPM QKALMVQKVR NTLEKAVTLA IGDGANDIAM
1260 1270 1280 1290 1300
IQEAHVGIGI AGREGLQAAR SSDFSIGRFK FLIKLLFCHG RWSYVRLSKY
1310 1320 1330 1340 1350
ILGTFYKEQF FFLMQAIMQP FVGYTGQSLY ESWGLTCFNT LFSSLCVIGL
1360 1370 1380 1390 1400
GIFEKDLSAS TVIAVPELYQ KGINNEAFNW RVYFGWCSIA FIQAFLVFYV
1410 1420 1430 1440 1450
TYSLFGMKEL NDNNIFAYGQ LIFTAAIFIM NFKLVFIEMQ YINIISIIVL
1460 1470 1480 1490 1500
VLTSLAWFLF NIFISEHYPD KNLYLARSQF LHHFGKNPSW WLTMLFVMVC
1510 1520 1530 1540 1550
ALTIDIVAQM LRRTLRPTDT DIFVEMENDA FVRSRFEQES GEFLQANAPS
1560
VDEIEQYLKS RD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB57447.1 |
PIRi | T41724 |
RefSeqi | XP_001713045.1, XM_001712993.2 |
Genome annotation databases
EnsemblFungii | SPAC821.13c.1; SPAC821.13c.1:pep; SPAC821.13c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB57447.1 |
PIRi | T41724 |
RefSeqi | XP_001713045.1, XM_001712993.2 |
3D structure databases
SMRi | Q9UT43 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 280591, 1 interactor |
STRINGi | 4896.SPAC821.13c.1 |
PTM databases
iPTMneti | Q9UT43 |
Proteomic databases
MaxQBi | Q9UT43 |
PaxDbi | Q9UT43 |
PRIDEi | Q9UT43 |
Genome annotation databases
EnsemblFungii | SPAC821.13c.1; SPAC821.13c.1:pep; SPAC821.13c |
Organism-specific databases
PomBasei | SPAC821.13c |
VEuPathDBi | FungiDB:SPAC821.13c |
Phylogenomic databases
eggNOGi | KOG0206, Eukaryota |
HOGENOMi | CLU_000846_5_2_1 |
InParanoidi | Q9UT43 |
OMAi | FIIMFNT |
PhylomeDBi | Q9UT43 |
Enzyme and pathway databases
Reactomei | R-SPO-6798695, Neutrophil degranulation R-SPO-936837, Ion transport by P-type ATPases |
Miscellaneous databases
PROi | PR:Q9UT43 |
Family and domain databases
Gene3Di | 3.40.1110.10, 2 hits 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006539, P-type_ATPase_IV IPR032631, P-type_ATPase_N IPR001757, P_typ_ATPase IPR032630, P_typ_ATPase_c IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF16212, PhoLip_ATPase_C, 1 hit PF16209, PhoLip_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01652, ATPase-Plipid, 2 hits TIGR01494, ATPase_P-type, 1 hit |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YFRD_SCHPO | |
Accessioni | Q9UT43Primary (citable) accession number: Q9UT43 Secondary accession number(s): Q9P6S8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2003 |
Last sequence update: | May 30, 2003 | |
Last modified: | February 23, 2022 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families