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UniProtKB - Q9USZ0 (WDR6_SCHPO)

Entry version 130 (10 Feb 2021)
Sequence version 1 (01 May 2000)
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Protein

Uncharacterized WD repeat-containing protein C1306.02

Gene

SPBC1306.02

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the regulation of the retromer complex and in the recycling from endosomes of plasma membrane proteins. May be involved in the methylation of the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of tRNA(Phe) and tRNA(Leu(UAA)) by SPAC4F10.03c (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • tRNA methylation Source: PomBase
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processtRNA processing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized WD repeat-containing protein C1306.02
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:SPBC1306.02, SPBC4.08
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

More...PomBasei		SPBC1306.02

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:SPBC1306.02

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003165671 – 984Uncharacterized WD repeat-containing protein C1306.02Add BLAST984

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9USZ0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9USZ0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		276462, 3 interactors

STRING: functional protein association networks

More...STRINGi		4896.SPBC1306.02.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9USZ0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati14 – 52WD 1Add BLAST39
Repeati142 – 183WD 2Add BLAST42
Repeati192 – 231WD 3Add BLAST40
Repeati235 – 275WD 4Add BLAST41
Repeati278 – 318WD 5Add BLAST41
Repeati326 – 364WD 6Add BLAST39
Repeati366 – 407WD 7Add BLAST42
Repeati461 – 502WD 8Add BLAST42
Repeati507 – 549WD 9Add BLAST43
Repeati650 – 689WD 10Add BLAST40
Repeati695 – 733WD 11Add BLAST39
Repeati752 – 797WD 12Add BLAST46
Repeati806 – 845WD 13Add BLAST40
Repeati854 – 899WD 14Add BLAST46
Repeati910 – 949WD 15Add BLAST40

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat WDR6 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0974, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002615_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9USZ0

Identification of Orthologs from Complete Genome Data

More...OMAi		CNSEGST

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9USZ0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00400, WD40, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00320, WD40, 8 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50978, SSF50978, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50082, WD_REPEATS_2, 3 hits
PS50294, WD_REPEATS_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9USZ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVEGDKGVL EPVNFVGPVT SLALIHNDKF LCCAQGPCLR IYDVSESRHE 
        60         70         80         90        100
SDLIKSILLP FHNRIHGMLP CKQGLFVWGG TYFAVVDVET SQVYYDRISD 
       110        120        130        140        150
WIFNAAELGE ENKFCVVTSK NQVHLLSLSK GSWEVTNTIS CEKTPLLFCA 
       160        170        180        190        200
TVQISGNEIY IASASAFQQI YVWKFNYNNP PSCVSIDTYL VGHEGACFDL 
       210        220        230        240        250
KFSSDGRYLC SVSEDRTLRL WSIESSPFLI ATGFGHSARV WRCVFLPNKE 
       260        270        280        290        300
IATVSEDLTL RLWTWNDKTL TNTYTYTGHR GKHIWSLVVS SANPIIYTGG 
       310        320        330        340        350
NDGSVRSWDY KTRIQESCIS VSSLFTSKTL LASFCFVKCQ KLLCLAKNGE 
       360        370        380        390        400
MSIIDNKGKK AIPALTTTSD MSIIRSWKNS FFVAAASNKG TIYVFSYQNT 
       410        420        430        440        450
NLLKAIDLHR GKIQQLLTYQ VKERYFLLSK SFVGKNQFRV YLQEFDFEAD 
       460        470        480        490        500
KVNLISTIEL ELPATFDPTS LTVDEEYSNF LIGSRTGSLA LYNIGESNYL 
       510        520        530        540        550
SVWRRIHEFD AISSIHIKSS KRDYLLIQTV GRDGYVNLFS IPRVEKSAVP 
       560        570        580        590        600
QELCSKKCCD GILSGGLCKK LKNGKENQWV WGFHASNFFL RDETNETNVF 
       610        620        630        640        650
FIDCGGSHRP WAFSMEMDIQ SFASYRANQL YIYSTALNLL QRNSVLQNGL 
       660        670        680        690        700
HGREIRAMDF NPSGDLLLSG SEDTKVTLLE FQSNGNIIPL NSVKFHNSGI 
       710        720        730        740        750
QSLTWFSDDI LFSTGGLEEL NVYRLIQKPE AYLKRIVHEK LCKPNKSNKT 
       760        770        780        790        800
YDGDLRITDI SVVKATHLGE RVLWINTVQS DSTIKAFTYN VDTKQLNCIK 
       810        820        830        840        850
SWKYKTVCLV FAEAVIFGSH LLLVVASTDG NVAIWNTFWR DPQIEPLIIW 
       860        870        880        890        900
IKTVHQFCVK SLNISRDQDV LTISTGGDDG AISRSILLLE QISENSVVVN 
       910        920        930        940        950
SLHNYFFAEA HASSVTGVLS ITKELLLSVS IDQRILLWKV EGDSLKPILE 
       960        970        980 
RYTHVADVGG MIRNNDFLII YGIGCEVFRL GSLR
Length:984
Mass (Da):110,977
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA9854A13B1E82A6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB62092.1

Protein sequence database of the Protein Information Resource

More...PIRi		T50309

NCBI Reference Sequences

More...RefSeqi		NP_595473.1, NM_001021384.2

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		SPBC1306.02.1; SPBC1306.02.1:pep; SPBC1306.02

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2539918

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		spo:SPBC1306.02

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB62092.1
PIRiT50309
RefSeqiNP_595473.1, NM_001021384.2

3D structure databases

SMRiQ9USZ0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi276462, 3 interactors
STRINGi4896.SPBC1306.02.1

Proteomic databases

MaxQBiQ9USZ0
PaxDbiQ9USZ0

Genome annotation databases

EnsemblFungiiSPBC1306.02.1; SPBC1306.02.1:pep; SPBC1306.02
GeneIDi2539918
KEGGispo:SPBC1306.02

Organism-specific databases

PomBaseiSPBC1306.02
VEuPathDBiFungiDB:SPBC1306.02

Phylogenomic databases

eggNOGiKOG0974, Eukaryota
HOGENOMiCLU_002615_0_1_1
InParanoidiQ9USZ0
OMAiCNSEGST
PhylomeDBiQ9USZ0

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9USZ0

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400, WD40, 3 hits
SMARTiView protein in SMART
SM00320, WD40, 8 hits
SUPFAMiSSF50978, SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS50082, WD_REPEATS_2, 3 hits
PS50294, WD_REPEATS_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR6_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9USZ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2000
Last modified: February 10, 2021
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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